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TussiCaps Side Effects

Generic Name: chlorpheniramine / hydrocodone

Note: This page contains side effects data for the generic drug chlorpheniramine / hydrocodone. It is possible that some of the dosage forms included below may not apply to the brand name TussiCaps.

For the Consumer

Applies to chlorpheniramine / hydrocodone: oral capsule extended release, oral suspension extended release

Other dosage forms:

As well as its needed effects, chlorpheniramine / hydrocodone may cause unwanted side effects that require medical attention.

Major Side Effects

If any of the following side effects occur while taking chlorpheniramine / hydrocodone, check with your doctor immediately:

Incidence not known:
  • Decrease in frequency of urination
  • decrease in urine volume
  • difficult, painful, or troubled breathing
  • difficulty in passing urine (dribbling)
  • irregular, fast or slow, or shallow breathing
  • pale or blue lips, fingernails, or skin
  • tightness in the chest

Minor Side Effects

Some chlorpheniramine / hydrocodone side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

Incidence not known:
  • Drowsiness
  • false or unusual sense of well-being
  • fear or nervousness
  • itching skin or rash
  • nausea
  • sleepiness
  • unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness
  • vomiting

For Healthcare Professionals

Applies to chlorpheniramine / hydrocodone: oral capsule extended release, oral liquid, oral suspension extended release

Nervous system

Nervous system side effects have included sedation, drowsiness, mental clouding, lethargy, impairment of mental performance, anxiety, fear, dysphoria, euphoria, dizziness, psychic dependence, and mood changes.[Ref]


Dermatologic side effects have included rash and pruritus.[Ref]


Gastrointestinal side effects have included nausea, vomiting, and constipation.[Ref]


Genitourinary side effects have included ureteral spasm, spasm of versicle sphincters, and urinary retention.[Ref]


Respiratory side effects have included respiratory depression, dryness of the pharynx, and occasional tightness of the chest.[Ref]

The long-acting hydrocodone-containing cough product (marketed as Tussionex Pennkinetic Extended-Release Suspension) may produce dose-related respiratory depression by acting directly on brain stem respiratory centers. Its use of been associated with fatal respiratory depression.[Ref]


General side effects have included impairment of physical performance.[Ref]


1. "Product Information. HyTan (chlorpheniramine-hydrocodone)." Prasco Laboratories, Cincinnati, OH.

2. "Product Information. Tussionex PennKinetic (chlorpheniramine-hydrocodone)." Aventis Pharmaceuticals, Bridgewater, NJ.

It is possible that some side effects of TussiCaps may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.