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Triavil Side Effects

Generic name: amitriptyline / perphenazine

Medically reviewed by Drugs.com. Last updated on Jul 24, 2023.

Note: This document contains side effect information about amitriptyline / perphenazine. Some dosage forms listed on this page may not apply to the brand name Triavil.

Applies to amitriptyline / perphenazine: oral tablet.

Warning

Oral route (Tablet)

Elderly patients with dementia-related psychosis treated with atypical antipsychotic drugs are at an increased risk of death compared to placebo. Although the causes of death in clinical trials were varied, most of the deaths appeared to be either cardiovascular (eg, heart failure, sudden death) or infectious (eg, pneumonia) in nature. Observational studies suggest that antipsychotic drugs may increase mortality. It is unclear from these studies to what extent the mortality findings may be attributed to the antipsychotic drug as opposed to patient characteristics. Perphenazine and amitriptyline hydrochloride is not approved for the treatment of patients with dementia-related psychosis.Antidepressants increased the risk of suicidal thinking and behavior in children, adolescents, and young adults in short-term studies with major depressive disorder (MDD) and other psychiatric disorders. Short term studies did not show an increase in the risk of suicidality with antidepressants compared to placebo in adults beyond age 24, and there was a reduction in risk with antidepressants compared to placebo in adults aged 65 and older. This risk must be balanced with the clinical need. Monitor patients closely for clinical worsening, suicidality, or unusual changes in behavior. Families and caregivers should be advised of the need for close observation and communication with the prescriber. Perphenazine and amitriptyline hydrochloride is not approved for use in pediatric patients.

Serious side effects of Triavil

Along with its needed effects, perphenazine (included in this combination medicine) can sometimes cause serious side effects. Tardive dyskinesia (a movement disorder) may occur and may not go away after you stop using the medicine. Signs of tardive dyskinesia include fine, worm-like movements of the tongue, or other uncontrolled movements of the mouth, tongue, cheeks, jaw, or arms and legs. Other serious but rare side effects may also occur. These include severe muscle stiffness, fever, unusual tiredness or weakness, fast heartbeat, difficult breathing, increased sweating, loss of bladder control, and seizures (neuroleptic malignant syndrome). You and your doctor should discuss the good this medicine will do as well as the risks of taking it.

Stop taking amitriptyline / perphenazine and get emergency help immediately if any of the following effects occur:

Rare

Check with your doctor as soon as possible if any of the following side effects occur while taking amitriptyline / perphenazine:

More common

Less common

Rare

Symptoms of overdose

Other side effects of Triavil

Some side effects of amitriptyline / perphenazine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Less common

After you stop using this medicine, it may still produce some side effects that need attention. During this period of time, Check with your doctor immediately if you notice the following side effects:

After you stop using this medicine, it may still produce some side effects that need attention. During this period of time, Check with your doctor immediately if you notice the following side effects:

For Healthcare Professionals

Applies to amitriptyline / perphenazine: oral tablet.

General

The most commonly reported side effects included sedation, dry mouth, and hypertension.[Ref]

Nervous system

Frequency not reported: Neurological impairments, sedation

Amitriptyline:

Frequency not reported: Altered electroencephalogram patterns, ataxia, coma, disturbed concentration, dizziness, drowsiness, dysarthria, extrapyramidal symptoms, extremity paresthesia, headache, incoordination, numbness, peculiar taste, peripheral neuropathy, seizures, stroke, tingling, tremors

Perphenazine:

Frequency not reported: Acute dyskinesia, akathisia, altered cerebrospinal fluid proteins, ataxia, cerebral edema, dystonia, extrapyramidal symptoms, grand mal convulsions, headache, hyperreflexia, hypnotic effects, motor restlessness, pseudoparkinsonism, tardive dyskinesia[Ref]

Cardiovascular

Frequency not reported: Hypertension

Amitriptyline:

Frequency not reported: Arrhythmias, edema, heart block, hypertension, hypotension, myocardial infarction orthostatic hypotension, palpitation, tachycardia

Perphenazine:

Frequency not reported: ECG abnormalities/quinidine-like effect, hypertension, hypotension, occasional change in pulse rate, peripheral edema, reversed epinephrine effect, tachycardia[Ref]

Gastrointestinal

Frequency not reported: Dry mouth

Amitriptyline:

Frequency not reported: Black tongue, constipation, diarrhea, dry mouth, epigastric distress, nausea, paralytic ileus, parotid swelling, stomatitis, tongue edema, vomiting

Perphenazine:

Frequency not reported: Constipation, dry mouth, nausea, obstipation, salivation, vomiting[Ref]

Psychiatric

Amitriptyline:

Frequency not reported: Anxiety, confusional state, decreased libido, delusions, disorientation, dream disturbance, excitement, hallucinations, hypomania, increased libido, insomnia, irritability, mania, nightmares, restlessness, sleep disturbance

Perphenazine:

Frequency not reported: catatonic-like state production, mild insomnia, paradoxical excitement, reactivation of psychoses[Ref]

Genitourinary

Amitriptyline:

Frequency not reported: Breast enlargement, galactorrhea, testicular swelling, urinary frequency, urinary retention, urinary tract dilation

Perphenazine:

Frequency not reported: Ejaculation failure, galactorrhea, hyperglycemia, lactation, menstrual cycle disturbances, urinary frequency, urinary incontinence[Ref]

Hematologic

Amitriptyline:

Frequency not reported: Agranulocytosis, bone marrow depression, eosinophilia, leukopenia, purpura, thrombocytopenia

Perphenazine:

Frequency not reported: Agranulocytosis, blood dyscrasias, eosinophilia, leukopenia, pancytopenia, thrombocytopenic purpura

Dermatologic

Amitriptyline:

Frequency not reported: Alopecia, facial edema, increased perspiration, photosensitization, skin rash, urticaria

Perphenazine:

Frequency not reported: Eczema, erythema, exfoliative dermatitis, itching, photosensitivity, pigmentation, urticaria[Ref]

Ocular

Amitriptyline:

Frequency not reported: Accommodation disturbance, blurred vision, increased intraocular pressure, mydriasis

Perphenazine:

Frequency not reported: Blurred vision, corneal pigmentation, lens pigmentation, photophobia, pigmentary retinopathy[Ref]

Hepatic

Amitriptyline:

Frequency not reported: Altered liver function, hepatitis, jaundice

Perphenazine:

Frequency not reported: Biliary stasis, jaundice, liver damage

Endocrine

Amitriptyline:

Frequency not reported: Gynecomastia, syndrome of inappropriate antidiuretic hormone secretion

Perphenazine:

Frequency not reported: False positive pregnancy test, gynecomastia[Ref]

Metabolic

Amitriptyline:

Frequency not reported: Anorexia, blood sugar level elevation/lowering, weight gain/loss

Perphenazine:

Frequency not reported: Anorexia, polyphagia[Ref]

Other

Amitriptyline:

Frequency not reported: Fatigue, hyperpyrexia, malaise, tinnitus, weakness

Perphenazine:

Frequency not reported: Lassitude[Ref]

Respiratory

Perphenazine:

Frequency not reported: Asthma, laryngeal edema, nasal congestion[Ref]

Hypersensitivity

Perphenazine:

Frequency not reported: Anaphylactoid reactions, angioneurotic edema[Ref]

Musculoskeletal

Amitriptyline:

Frequency not reported: Muscle weakness[Ref]

Immunologic

Perphenazine:

Frequency not reported: Immunologic reactions[Ref]

References

1. Product Information. Etrafon 2-10 (amitriptyline-perphenazine). Schering Corporation. PROD.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.