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Tri-Gestan S Side Effects

Generic Name: chlorpheniramine / phenylephrine / pyrilamine

Note: This document contains side effect information about chlorpheniramine / phenylephrine / pyrilamine. Some of the dosage forms listed on this page may not apply to the brand name Tri-Gestan S.

For the Consumer

Applies to chlorpheniramine / phenylephrine / pyrilamine: oral liquid, oral suspension, oral suspension extended release, oral tablet, oral tablet extended release

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using this medicine and call your doctor at once if you have:

  • confusion, hallucinations;

  • feeling nervous or irritable;

  • trouble sleeping;

  • little or no urination;

  • a seizure (convulsions);

  • numbness or tingly feeling;

  • a light-headed feeling, like you might pass out;

  • pounding heartbeats or fluttering in your chest; or

  • increased blood pressure--severe headache, blurred vision, pounding in your neck or ears, anxiety, nosebleed.

Side effects may be more likely in older adults.

Common side effects may include:

  • nausea, constipation, loss of appetite;

  • rash or itching;

  • increased sweating;

  • dry mouth, nose, or throat;

  • blurred vision;

  • headache, dizziness; or

  • feeling restless or excited (especially in children).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For Healthcare Professionals

Applies to chlorpheniramine/phenylephrine/pyrilamine: oral liquid, oral suspension, oral suspension extended release, oral tablet, oral tablet extended release

Nervous system

Nervous system side effects including drowsiness and sedation have been reported.[Ref]


Gastrointestinal side effects including dryness of the mucous membranes have been reported.[Ref]


1. "Product Information. Poly Hist PD (chlorpheniramine / phenylephrine / pyrilamine)." Poly Pharmaceuticals Inc, Quitman, MS.

2. "PDR Generics. 4th ed." Montvale, NJ: Medical Economics (1998):

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

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