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Poly Hist PD (old formulation)

Generic Name: chlorpheniramine, phenylephrine, and pyrilamine (KLOR fe NEER a meen, pir IL a meen, FEN il EFF rin)
Brand Name: Chlorex-A 12, Conal, MyHist-PD, Nalex A 12, Phena-Plus, Phena-S, Poly Hist PD (old formulation), Ru-Hist Forte

What is chlorpheniramine, phenylephrine, and pyrilamine?

Chlorpheniramine and pyrilamine are antihistamines that reduce the effects of natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.

Phenylephrine is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose).

Chlorpheniramine, phenylephrine, and pyrilamine is a combination medicine used to treat runny or stuffy nose, sneezing, itching, watery eyes, and sinus congestion caused by allergies, the common cold, or the flu.

Chlorpheniramine, phenylephrine, and pyrilamine may also be used for purposes not listed in this medication guide.

What is the most important information I should know about chlorpheniramine, phenylephrine, and pyrilamine?

You should not use this medicine if you have severe coronary artery disease, diabetes, an overactive thyroid, asthma, pneumonia, or other breathing problems.

Do not use this medicine if you have used an MAO inhibitor in the past 14 days, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine.

Do not give this medication to a child younger than 6 years old. Death can occur from the misuse of cough and cold medicines in very young children.

You should not use antihistamine medication to make a child sleepy.

What should I discuss with my healthcare provider before taking chlorpheniramine, phenylephrine, and pyrilamine?

Do not use this medicine if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others.

You should not use this medicine if you are allergic to chlorpheniramine, phenylephrine, pyrilamine, or to other decongestants, or if you have:

  • severe coronary artery disease;

  • diabetes;

  • overactive thyroid; or

  • asthma, pneumonia, or other breathing problems.

Ask a doctor or pharmacist if it is safe for you to take this medicine if you have:

  • heart disease or high blood pressure;

  • blood circulation problems;

  • glaucoma;

  • an ulcer or obstruction in the stomach;

  • enlarged prostate;

  • bladder obstruction or other urination problems; or

  • a history of seizures.

It is not known whether chlorpheniramine, phenylephrine, and pyrilamine will harm an unborn baby. Ask a doctor before using this medicine if you are pregnant.

Chlorpheniramine, phenylephrine, and pyrilamine can pass into breast milk and may cause side effects in the nursing baby. Antihistamines can also slow breast milk production. You should not breast-feed while using this medicine.

How should I take chlorpheniramine, phenylephrine, and pyrilamine?

Use exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. Cough or cold medicine is usually taken only for a short time until your symptoms clear up.

Do not give this medication to a child younger than 6 years old. Always ask a doctor before giving a cough or cold medicine to a child. Death can occur from the misuse of cough and cold medicines in very young children.

You should not use antihistamine medication to make a child sleepy.

Do not crush, chew, or break an extended-release tablet. Swallow it whole.

Measure liquid medicine with the dosing syringe provided, or with a special dose-measuring spoon or medicine cup. If you do not have a dose-measuring device, ask your pharmacist for one.

Shake the oral suspension (liquid) well just before you measure a dose.

Store at room temperature away from moisture, heat, and light. Do not allow liquid medicine to freeze.

Call your doctor if your symptoms do not improve after 7 days of treatment, or if you have a fever with a headache, cough, or skin rash.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include dry mouth, extreme drowsiness, confusion, ringing in your ears, tremors, seizure, dilated pupils, vomiting, and loss of consciousness.

What should I avoid while taking chlorpheniramine, phenylephrine, and pyrilamine?

This medicine may cause blurred vision and may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert and able to see clearly.

Drinking alcohol with this medicine can cause side effects.

Ask a doctor or pharmacist before using any other cold, cough, allergy, or pain medicine. Many combination medicines contain antihistamines and decongestants. Taking certain products together can cause you to get too much of these medicines.

Avoid exposure to sunlight or tanning beds. This medicine can make you sunburn more easily. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.

Chlorpheniramine, phenylephrine, and pyrilamine side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using this medicine and call your doctor at once if you have:

  • confusion, hallucinations;

  • feeling nervous or irritable;

  • trouble sleeping;

  • little or no urination;

  • a seizure (convulsions);

  • numbness or tingly feeling;

  • a light-headed feeling, like you might pass out;

  • pounding heartbeats or fluttering in your chest; or

  • increased blood pressure--severe headache, blurred vision, pounding in your neck or ears, anxiety, nosebleed.

Side effects may be more likely in older adults.

Common side effects may include:

  • nausea, constipation, loss of appetite;

  • rash or itching;

  • increased sweating;

  • dry mouth, nose, or throat;

  • blurred vision;

  • headache, dizziness; or

  • feeling restless or excited (especially in children).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

What other drugs will affect chlorpheniramine, phenylephrine, and pyrilamine?

Ask a doctor or pharmacist before using this medicine if you are also using any other drugs, including prescription and over-the-counter medicines, vitamins, and herbal products. Some medicines can cause unwanted or dangerous effects when used together. Not all possible interactions are listed in this medication guide.

Taking this medicine with other drugs that make you sleepy or slow your breathing can worsen these effects. Ask your doctor before taking chlorpheniramine, phenylephrine, and pyrilamine with a sleeping pill, narcotic pain medicine, muscle relaxer, or medicine for anxiety, depression, or seizures.

More about Poly Hist PD (old formulation) (chlorpheniramine / phenylephrine / pyrilamine)

Consumer resources

Other brands: Phena-S, Phena-S 12, Ru-Hist Forte, Phena-Plus, More... (5)

Professional resources

Where can I get more information?

  • Your pharmacist can provide more information about chlorpheniramine, phenylephrine, and pyrilamine.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
  • Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2012 Cerner Multum, Inc. Version: 9.01.

Date modified: June 01, 2017
Last reviewed: May 03, 2017

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