Chlorpheniramine / Phenylephrine / Pyrilamine Dosage
Medically reviewed by Drugs.com. Last updated on Sep 1, 2023.
Applies to the following strengths: 8 mg-25 mg-25 mg; 2 mg-5 mg-12.5 mg/5 mL; 4 mg-10 mg-25 mg; 2 mg-10 mg-10 mg/5 mL; 2 mg-7.5 mg-12.5 mg/5 mL; 2 mg-10 mg-10 mg; 8 mg-15 mg-12.5 mg/5 mL
Usual Adult Dose for:
Usual Pediatric Dose for:
Additional dosage information:
Usual Adult Dose for Allergic Rhinitis
Chlorpheniramine/phenylephrine/pyrilamine 2 mg-7.5 mg-12.5 mg/5 mL:
5 to 10 mL orally every 4 to 6 hours not to exceed 60 mg of phenylephrine in 24 hours.
Chlorpheniramine/phenylephrine/pyrilamine 4 mg-10 mg-25 mg oral tablet, extended release:
1 tablet orally 2 to 3 times daily.
Chlorpheniramine/phenylephrine/pyrilamine 8 mg-12.5 mg-15 mg/5 mL:
5 to 10 mL orally every 12 hours not to exceed 20 mL in 24 hours.
Chlorpheniramine/phenylephrine/pyrilamine 2 mg-10 mg-10 mg oral tablet:
1 to 2 tablets orally every 4 to 6 hours.
Usual Adult Dose for Cold Symptoms
Chlorpheniramine/phenylephrine/pyrilamine 2 mg-7.5 mg-12.5 mg/5 mL:
5 to 10 mL orally every 4 to 6 hours not to exceed 60 mg of phenylephrine in 24 hours.
Chlorpheniramine/phenylephrine/pyrilamine 4 mg-10 mg-25 mg oral tablet, extended release:
1 tablet orally 2 to 3 times daily.
Chlorpheniramine/phenylephrine/pyrilamine 8 mg-12.5 mg-15 mg/5 mL:
5 to 10 mL orally every 12 hours not to exceed 20 mL in 24 hours.
Chlorpheniramine/phenylephrine/pyrilamine 2 mg-10 mg-10 mg oral tablet:
1 to 2 tablets orally every 4 to 6 hours.
Usual Pediatric Dose for Allergic Rhinitis
Chlorpheniramine/phenylephrine/pyrilamine 2 mg-5 mg-12.5 mg/5 mL:
2 years to 6 years: 2.5 to 5 mL orally every 12 hours as needed.
6 years or older: 5 to 10 mL orally every 12 hours as needed.
Chlorpheniramine/phenylephrine/pyrilamine 2 mg-7.5 mg-12.5 mg/5 mL:
2 yrs to 5 yrs: 2.5 mL orally every 4 to 6 hours not to exceed 15 mg of phenylephrine in 24 hours.
6 yrs to 11 yrs: 5 mL orally every 4 to 6 hours not to exceed 30 mg of phenylephrine in 24 hours.
12 years or older: 5 to 10 mL orally every 4 to 6 hours not to exceed 60 mg of phenylephrine in 24 hours.
Chlorpheniramine/phenylephrine/pyrilamine 4 mg-10 mg-25 mg oral tablet, extended release:
6 yrs to 11 yrs: 1/2 tablet orally 2 to 3 times daily.
12 years or older: 1 tablet orally 2 to 3 times daily.
Chlorpheniramine/phenylephrine/pyrilamine 8 mg-12.5 mg-15 mg/5 mL:
2 yrs to 5 yrs: 2.5 mL orally every 12 hours not to exceed 5 mL in 24 hours.
6 yrs to 12 yrs: 5 mL orally every 12 hours not to exceed 10 mL 24 hours.
12 years or older: 5 to 10 mL orally every 12 hours not to exceed 20 mL in 24 hours.
Chlorpheniramine/phenylephrine/pyrilamine 2 mg-10 mg-10 mg oral tablet:
6 yrs to 12 yrs: 1 tablet orally every 4 to 6 hours.
12 years or older: 1 to 2 tablets orally every 4 to 6 hours.
Usual Pediatric Dose for Cold Symptoms
Chlorpheniramine/phenylephrine/pyrilamine 2 mg-5 mg-12.5 mg/5 mL:
2 years to 6 years: 2.5 to 5 mL orally every 12 hours as needed.
6 years or older: 5 to 10 mL orally every 12 hours as needed.
Chlorpheniramine/phenylephrine/pyrilamine 2 mg-7.5 mg-12.5 mg/5 mL:
2 yrs to 5 yrs: 2.5 mL orally every 4 to 6 hours not to exceed 15 mg of phenylephrine in 24 hours.
6 yrs to 11 yrs: 5 mL orally every 4 to 6 hours not to exceed 30 mg of phenylephrine in 24 hours.
12 years or older: 5 to 10 mL orally every 4 to 6 hours not to exceed 60 mg of phenylephrine in 24 hours.
Chlorpheniramine/phenylephrine/pyrilamine 4 mg-10 mg-25 mg oral tablet, extended release:
6 yrs to 11 yrs: 1/2 tablet orally 2 to 3 times daily.
12 years or older: 1 tablet orally 2 to 3 times daily.
Chlorpheniramine/phenylephrine/pyrilamine 8 mg-12.5 mg-15 mg/5 mL:
2 yrs to 5 yrs: 2.5 mL orally every 12 hours not to exceed 5 mL in 24 hours.
6 yrs to 12 yrs: 5 mL orally every 12 hours not to exceed 10 mL 24 hours.
12 years or older: 5 to 10 mL orally every 12 hours not to exceed 20 mL in 24 hours.
Chlorpheniramine/phenylephrine/pyrilamine 2 mg-10 mg-10 mg oral tablet:
6 yrs to 12 yrs: 1 tablet orally every 4 to 6 hours.
12 years or older: 1 to 2 tablets orally every 4 to 6 hours.
Renal Dose Adjustments
Data not available
Liver Dose Adjustments
Data not available
Precautions
Use with caution in patients with hypertension, cardiovascular disease, hyperthyroidism, diabetes, narrow angle glaucoma or prostatic hypertrophy.
Dialysis
Data not available
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