Chlorpheniramine / phenylephrine / pyrilamine Side Effects
For the Consumer
Applies to chlorpheniramine/phenylephrine/pyrilamine: oral liquid, oral suspension, oral suspension extended release, oral tablet, oral tablet extended release
Do not give this medication to a child younger than 6 years old. Death can occur from the misuse of cough and cold medicines in very young children.
You should not use antihistamine medication to make a child sleepy.
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Stop using this medicine and call your doctor at once if you have:
feeling nervous or irritable;
little or no urination;
a seizure (convulsions);
numbness or tingly feeling;
a light-headed feeling, like you might pass out;
pounding heartbeats or fluttering in your chest; or
Side effects may be more likely in older adults.
Common side effects may include:
rash or itching;
dry mouth, nose, or throat;
headache, dizziness; or
feeling restless or excited (especially in children).
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.
For Healthcare Professionals
Nervous system side effects including drowsiness and sedation have been reported.[Ref]
Gastrointestinal side effects including dryness of the mucous membranes have been reported.[Ref]
More about chlorpheniramine / phenylephrine / pyrilamine
- Drug interactions
- Dosage information
- During pregnancy
- Drug images
- En español
- Drug class: upper respiratory combinations
Related treatment guides
1. "PDR Generics." Montvale, NJ: Medical Economics (1998):
2. "Product Information. Poly Hist PD (chlorpheniramine / phenylephrine / pyrilamine)." Poly Pharmaceuticals Inc (2005):
Some side effects may not be reported. You may report them to the FDA.