Skip to Content

Tranxene SD Side Effects

Generic name: clorazepate

Medically reviewed by Drugs.com. Last updated on Feb 22, 2021.

Note: This document contains side effect information about clorazepate. Some of the dosage forms listed on this page may not apply to the brand name Tranxene SD.

For the Consumer

Applies to clorazepate: oral tablet

Warning

Oral route (Tablet)

Risks from concomitant use with opioids; abuse, misuse, and addiction; and dependence and withdrawal reactions:Concomitant use of benzodiazepines and opioids may result in profound sedation, respiratory depression, coma, and death. Reserve concomitant prescribing of these drugs in patients for whom alternative treatment options are inadequate. Limit dosages and durations to the minimum required. Follow patients for signs and symptoms of respiratory depression and sedation.The use of benzodiazepines, including clorazepate, exposes users to risks of abuse, misuse, and addiction, which can lead to overdose or death. Abuse and misuse of benzodiazepines commonly involve concomitant use of other medications, alcohol, and/or illicit substances, which is associated with an increased frequency of serious adverse outcomes. Before prescribing clorazepate and throughout out treatment, assess each patient’s risk for abuse, misuse, and addiction.The continued use of benzodiazepines, including clorazepate, may lead to clinically significant physical dependence. The risks of dependence and withdrawal increase with longer treatment duration and higher daily dose. Abrupt discontinuation or rapid dosage reduction of clorazepate after continued use may precipitate acute withdrawal reactions, which can be life-threatening. To reduce the risk of withdrawal reactions, use a gradual taper to discontinue clorazepate or reduce the dosage.

Side effects requiring immediate medical attention

Along with its needed effects, clorazepate (the active ingredient contained in Tranxene SD) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking clorazepate:

Less common

  • Bladder pain
  • bloody or cloudy urine
  • difficult, burning, or painful urination
  • frequent urge to urinate
  • lower back or side pain
  • shakiness and unsteady walk
  • slurred speech
  • trembling or shaking of the hands or feet
  • unsteadiness, trembling, or other problems with muscle control or coordination

Get emergency help immediately if any of the following symptoms of overdose occur while taking clorazepate:

Symptoms of overdose

  • Change in consciousness
  • drowsiness
  • loss of consciousness
  • mood or mental changes
  • sleepiness

Side effects not requiring immediate medical attention

Some side effects of clorazepate may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

  • Blurred vision
  • diarrhea
  • discouragement
  • dizziness
  • double vision
  • dry mouth
  • feeling sad or empty
  • headache
  • indigestion
  • irritability
  • loss of appetite
  • loss of interest or pleasure
  • mental confusion
  • nausea or vomiting
  • nervousness
  • passing of gas
  • seeing double
  • skin rash
  • stomach pain, fullness, or discomfort
  • trouble with concentrating
  • trouble with sleeping
  • unusual tiredness or weakness

For Healthcare Professionals

Applies to clorazepate: oral tablet

General

The most commonly reported side effect was drowsiness.[Ref]

Nervous system

Frequency not reported: Ataxia, dizziness, drowsiness, headache, nervousness, slurred speech[Ref]

Psychiatric

Frequency not reported: Depression, insomnia, irritability, mental confusion, suicidal ideation/behavior[Ref]

Gastrointestinal

Frequency not reported: Dry mouth, various gastrointestinal complaints[Ref]

Ocular

Frequency not reported: Blurred vision, diplopia[Ref]

Dermatologic

Frequency not reported: Transient skin rash[Ref]

Other

Frequency not reported: Fatigue[Ref]

Genitourinary

Frequency not reported: Genitourinary complaints[Ref]

Hepatic

Frequency not reported: Abnormal liver function tests[Ref]

Renal

Frequency not reported: Abnormal kidney function tests[Ref]

Hematologic

Frequency not reported: Decreased hematocrit[Ref]

Cardiovascular

Frequency not reported: Decrease in systolic blood pressure[Ref]

References

1. "Product Information. Tranxene (clorazepate)." Abbott Pharmaceutical, Abbott Park, IL.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.