Topco Allergy Side Effects

Generic name: chlorpheniramine

Medically reviewed by Drugs.com. Last updated on Jan 26, 2024.

Note: This document provides detailed information about Topco Allergy Side Effects associated with chlorpheniramine. Some dosage forms listed on this page may not apply specifically to the brand name Topco Allergy.

Applies to chlorpheniramine: oral syrup, oral tablet, oral tablet extended release.

Serious side effects of Topco Allergy

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

• Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.

Other side effects of Topco Allergy

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

• Feeling sleepy.
• Feeling nervous and excitable.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-332-1088. You may also report side effects at https://www.fda.gov/medwatch.

For healthcare professionals

Applies to chlorpheniramine: compounding powder, injectable solution, oral capsule extended release, oral liquid, oral suspension extended release, oral syrup, oral tablet, oral tablet chewable, oral tablet extended release.

Nervous system adverse events

• Very common (10% or more): Sedation, somnolence
• Common (1% to 10%): Disturbance in attention, abnormal coordination, dizziness, headache^[Ref]

Nearly all patients treated with chlorpheniramine experience drowsiness. This drowsiness may subside in some patients with extended use.

Few cases of dyskinesias and tremors, often of the face, have been reported in patients whose chronic use of chlorpheniramine extended over a period of 3 to 10 years. Some of these cases were only partially relieved by discontinuation of the drug. Haloperidol was successful in relieving symptoms.^[Ref]

Cardiovascular

• Frequency not reported: Palpitations, tachycardia, arrhythmias, hypotension^[Ref]

Ocular

• Common (1% to 10%): Blurred vision^[Ref]

Gastrointestinal

• Common (1% to 10%): Nausea, dry mouth
• Frequency not reported: Vomiting, abdominal pain, diarrhea, dyspepsia^[Ref]

Hypersensitivity

• Frequency not reported: Allergic reaction, angioedema, anaphylactic reactions^[Ref]

Dermatologic

• Frequency not reported: Exfoliative dermatitis, rash, urticaria, photosensitivity^[Ref]

Other

• Common (1% to 10%): Fatigue
• Frequency not reported: Tinnitus, chest tightness^[Ref]

Psychiatric

• Frequency not reported: Confusion, excitation, irritability, nightmares, depression^[Ref]

Hematologic

• Frequency not reported: Hemolytic anemia, blood dyscrasias^[Ref]

A fatal case of agranulocytosis has been reported in a patient taking chlorpheniramine, pseudoephedrine, acetaminophen, dextromethorphan, phenylpropanolamine, and aspirin. Chlorpheniramine was felt to be the cause.^[Ref]

Genitourinary

• Frequency not reported: Urinary retention^[Ref]

Musculoskeletal

• Frequency not reported: Muscle twitching, muscle weakness^[Ref]

Hepatic

• Frequency not reported: Hepatitis, jaundice^[Ref]

Respiratory

• Frequency not reported: Thickening of bronchial secretions^[Ref]

Metabolic

• Frequency not reported: Anorexia^[Ref]

Frequently asked questions

• Can you take antihistamines when pregnant?

Further information

Topco Allergy side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer