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Tolectin 600 Side Effects

Generic Name: tolmetin

Note: This document contains side effect information about tolmetin. Some of the dosage forms listed on this page may not apply to the brand name Tolectin 600.

For the Consumer

Applies to tolmetin: oral capsule, oral tablet

Along with its needed effects, tolmetin (the active ingredient contained in Tolectin 600) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking tolmetin:

More Common

Less Common

  • Black, tarry stools
  • bladder pain
  • blood in the vomit
  • bloody or cloudy urine
  • blurred or loss of vision
  • burning feeling in the chest or stomach
  • burning, itching, redness, or stinging of the skin
  • chest pain
  • difficult, burning, or painful urination
  • disturbed color perception
  • double vision
  • frequent urge to urinate
  • halos around lights
  • indigestion
  • lower back or side pain
  • night blindness
  • overbright appearance of lights
  • severe or continuing stomach pain
  • stomach upset
  • tenderness in the stomach area
  • tunnel vision

Rare

  • Back or leg pains
  • bleeding gums
  • blistering, peeling, or loosening of the skin
  • chills
  • constipation
  • cough or hoarseness
  • dark urine
  • decreased urine output
  • difficulty with breathing
  • difficulty with swallowing
  • dilated neck veins
  • extreme fatigue
  • fast, irregular heartbeat
  • feeling of discomfort
  • fever
  • general body swelling
  • heartburn
  • hives or welts
  • increased thirst
  • inflammation of the joints
  • irregular breathing
  • joint or muscle pain
  • light-colored stools
  • loss of appetite
  • muscle aches
  • nosebleeds
  • pale skin
  • pinpoint red spots on the skin
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • red skin lesions, often with a purple center
  • red, irritated eyes
  • severe and continuing nausea
  • shortness of breath
  • skin rash
  • sore throat
  • sores, ulcers, or white spots on the lips or in the mouth
  • swelling of the face, fingers, feet, or lower legs
  • swollen, painful, or tender lymph glands in the neck, armpit, or groin
  • tightness in the chest
  • trouble with breathing
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • upper right abdominal pain
  • wheezing
  • yellow eyes and skin

Some side effects of tolmetin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More Common

  • Acid or sour stomach
  • belching
  • bloated full feeling
  • excess air or gas in the stomach or intestines
  • lack or loss of strength
  • passing gas
  • stomach discomfort
  • weight loss

Less Common

  • Continuing ringing or buzzing or other unexplained noise in the ears
  • discouragement
  • feeling sad or empty
  • hearing loss
  • irritability
  • loss of interest or pleasure
  • sleepiness
  • tiredness
  • trouble with concentrating
  • trouble with sleeping

Rare

  • Redness, swelling, or soreness of the tongue
  • swelling or inflammation of the mouth

For Healthcare Professionals

Applies to tolmetin: oral capsule, oral tablet

Gastrointestinal

Very common (10% or more): Nausea (11%)

Common (1% to 10%): Dyspepsia, gastrointestinal (GI) distress, abdominal pain, diarrhea, flatulence, vomiting, constipation, gastritis, peptic ulcer

Frequency not reported: GI bleeding, GI perforation, glossitis, stomatitis[Ref]

Hepatic

Frequency not reported: Hepatitis, liver function abnormalities[Ref]

Nervous system

Common (1% to 10%): Headache, dizziness, drowsiness[Ref]

Hematologic

Common (1% to 10%): Hemoglobin decreased, hematocrit decreased

Frequency not reported: Lymphadenopathy, hemolytic anemia, thrombocytopenia, granulocytopenia, agranulocytosis[Ref]

Renal

Common (1% to 10%): BUN increased

Frequency not reported: Renal failure[Ref]

Hypersensitivity

Frequency not reported: Anaphylactoid reactions[Ref]

Dermatologic

Common (1% to 10%): Skin irritation

Frequency not reported: Urticaria, purpura, erythema multiforme, toxic epidermal necrolysis[Ref]

Cardiovascular

Common (1% to 10%): Blood pressure increased

Frequency not reported: Congestive heart failure[Ref]

General

The most frequently reported side effect was nausea.[Ref]

Genitourinary

Common (1% to 10%): Urinary tract infection

Frequency not reported: Hematuria, proteinuria, dysuria[Ref]

Immunologic

Frequency not reported: Serum sickness

Ocular

Common (1% to 10%): Visual disturbance

Frequency not reported: Optic neuropathy, retinal/macular changes[Ref]

Other

Common (1% to 10%): Asthenia, chest pain, edema, weight gain, weight loss, tinnitus

Frequency not reported: Fever[Ref]

Psychiatric

Common (1% to 10%): Depression[Ref]

Respiratory

Frequency not reported: Epistaxis[Ref]

References

1. "Product Information. Tolectin (tolmetin)." McNeil Pharmaceutical, Raritan, NJ.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

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