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Tioconazole topical Side Effects

For the Consumer

Applies to tioconazole topical: intravaginal ointment

Side effects include:

Vulvovaginal burning, irritation, vaginitis, pruritus, headache.

For Healthcare Professionals

Applies to tioconazole topical: vaginal ointment w/applicator

Local

Local side effects have been commonly reported. These have involved the genitourinary area (occurring in up to 7% of treated patients), and have included burning, itching, and, less commonly, pain, irritation, and dryness.[Ref]

Hypersensitivity

Hypersensitivity side effects have included contact dermatitis in patients using a topical nail solution (not available in the US). Most patients had been using the product for several weeks when dermatitis developed. Cross-sensitivity to other imidazoles has been reported.[Ref]

References

1. "Product Information. Vagistat-1 (tioconazole)." Bristol-Myers Squibb, Princeton, NJ.

2. Stein GE, Gurwith D, Mummaw N, Gurwith M "Single-dose tioconazole compared with 3-day clotrimazole treatment in vulvovaginal candidiasis." Antimicrob Agents Chemother 29 (1986): 969-71

3. Clissold SP, Heel RC "Tioconazole. A review of its antimicrobial activity and therapeutic use in superficial mycoses." Drugs 31 (1986): 29-51

4. Onayemi O, Aldridge RD, Shaw S "Allergic contact dermatitis from tioconazole. A report of 2 cases." Contact Dermatitis 26 (1992): 193-4

5. Jones SK, Kennedy CT "Contact dermatitis from tioconazole." Contact Dermatitis 22 (1990): 122-3

6. Piletta P, Pasche-Koo F, Saurat JH "Contact dermatitis from tioconazole mimicking "one hand two feet syndrome"." Contact Dermatitis 28 (1993): 308

7. Marren P, Powell S "Contact sensitivity to tioconazole and other imidazoles." Contact Dermatitis 27 (1992): 129-30

8. Gibson G, Buckley A, Murphy GM "Allergic contact dermatitis from tioconazole without cross- sensitivity to other imidazoles." Contact Dermatitis 30 (1994): 308

9. Faria A, Goncalo S, Goncalo M, Freitas C, Baptista PP "Allergic contact dermatitis from tioconazole." Contact Dermatitis 35 (1996): 250-2

10. Stubb S, Heikkila H, Reitamo S, Forstrom L "Contact allergy to tioconazole." Contact Dermatitis 26 (1992): 155-8

11. Brunelli D, Vincenzi C, Morelli R, Tosti A "Contact dermatitis from tioconazole." Contact Dermatitis 27 (1992): 120

12. Izu R, Aguirre A, Gonzalez M, Diaz-Perez JL "Contact dermatitis from tioconazole with cross-sensitivity to other imidazoles." Contact Dermatitis 26 (1992): 130-1

13. Quirino AP, Barros MA "Contact dermatitis from tioconazole." Contact Dermatitis 30 (1994): 240-1

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

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