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Tilade Side Effects

Generic Name: nedocromil

Note: This document contains side effect information about nedocromil. Some of the dosage forms listed on this page may not apply to the brand name Tilade.

Applies to nedocromil: inhalation aerosol with adapter

Gastrointestinal

Gastrointestinal side effects have included unpleasant taste which was reported in approximately 13% of patients receiving nedocromil (the active ingredient contained in Tilade) and resulted in drug withdrawal in up to 3%. Less commonly, nedocromil has caused nausea and vomiting (2% to 4%).[Ref]

Respiratory

Throat irritation may be relieved by drinking water before and after inhalation of nedocromil (the active ingredient contained in Tilade) Use of a beta-2 agonist prior to nedocromil inhalation may relieve cough and bronchospasm.[Ref]

Respiratory side effects have included cough and throat irritation in 6% to 7% of patients treated with nedocromil. Bronchospasm has been induced in 5% of patients.[Ref]

Nervous system

Nervous system side effects have included headache in up to 6% of patients treated. Less commonly dizziness has been reported.[Ref]

Hepatic

Hepatic side effects have included elevations of liver function tests (SGPT) in approximately 3% of patients treated with nedocromil (the active ingredient contained in Tilade) [Ref]

References

1. Dejong JW, Teengs JP, Postma DS, Vandermark TW, Koeter GH, Demonchy JGR "Nedocromil sodium versus albuterol in the management of allergic asthma." Am J Respir Crit Care Med 149 (1994): 91-7

2. Rebuck AS, Kesten S, Boulet LP, Cartier A, Cockcroft D, Gruber J, Laberge F, Lee-Chuy E, Keshmiri M, MacDonald GF, et al "A 3-month evaluation of the efficacy of nedocromil sodium in asthma: a randomized, double-blind, placebo-controlled trial of nedocromil sodium conducted by a Canadian multicenter study group." J Allergy Clin Immunol 85 (1990): 612-7

3. Gonzalez JP, Brogden RN "Nedocromil sodium. A preliminary review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in the treatment of reversible obstructive airways disease." Drugs 34 (1987): 560-77

4. Foulds RA "An overview of human safety data with nedocromil sodium." J Allergy Clin Immunol 92 (1993): 202-4

5. Brogden RN, Sorkin EM "Nedocromil sodium. An updated review of its pharmacological properties and therapeutic efficacy in asthma." Drugs 45 (1993): 693-715

6. "Product Information. Tilade (nedocromil)." Rhone-Poulenc Rorer, Collegeville, PA.

7. Parish RC, Miller LJ "Nedocromil sodium." Ann Pharmacother 27 (1993): 599-606

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.