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Thyrotropin alpha Side Effects

Medically reviewed by Last updated on Nov 23, 2020.

For the Consumer

Applies to thyrotropin alpha: intramuscular solution reconstituted

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Weakness on 1 side of the body, trouble speaking or thinking, change in balance, drooping on one side of the face, or blurred eyesight.

What are some other side effects of this drug?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-332-1088. You may also report side effects at

For Healthcare Professionals

Applies to thyrotropin alpha: intramuscular powder for injection


Postmarketing reports: Hypersensitivity (including urticaria, rash, pruritus, flushing, respiratory signs/symptoms)


Common (1% to 10%): Fatigue

Postmarketing reports: Stroke, transient influenza-like symptoms (less than 48 hours, including fever over 100F, chills/shivering, myalgia/arthralgia, fatigue/asthenia/malaise, respiratory signs/symptoms), enlargement of residual thyroid tissue or metastases


Very common (10% or more): Nausea (11%)

Common (1% to 10%): Vomiting[Ref]


Postmarketing reports: Injection site reactions (including pain, erythema, bruising, pruritus)

Nervous system

Common (1% to 10%): Headache[Ref]


1. "Product Information. Thyrogen (thyrotropin alpha)." Genzyme Corporation, Cambridge, MA.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.