Thyrotropin alpha Side Effects
For the Consumer
Applies to thyrotropin alpha: injection powder for solution
Along with its needed effects, thyrotropin alpha may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur while taking thyrotropin alpha:More common
- Inability to move the legs or arms
- paralysis of one side of the body
- itching, redness, or swelling at the injection site
- skin rash
- tightness of the throat
- Feeling of warmth
- hives or welts
- loss of vision
- redness of the face, neck, arms, and occasionally, upper chest
- redness of the skin
- difficult or labored breathing
- difficulty with speaking
- difficulty with swallowing
- double vision
- fast, slow, or irregular heartbeat
- inability to move the facial muscles
- inability to speak
- muscle or joint pain
- noisy breathing
- slow or irregular breathing
- slow speech
- sore throat
- voice changes
Get emergency help immediately if any of the following symptoms of overdose occur while taking thyrotropin alpha:Symptoms of overdose
- Blurred vision
- chest pain
- dizziness dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
- fast or irregular heartbeat
- increased sweating
- shortness of breath
Some side effects of thyrotropin alpha may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:More common
- Flushing of the face
- frequent urge to urinate
- stomach discomfort
- Burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
- lack or loss of strength
- muscle aches
- sore throat
- stuffy or runny nose
- trouble sleeping
For Healthcare Professionals
Applies to thyrotropin alpha: intramuscular powder for injection
Gastrointestinal side effects have included nausea, vomiting, and diarrhea.[Ref]
Musculoskeletal side effects have included myalgia and arthralgia.[Ref]
General side effects have included influenza-like symptoms, also called flu-like symptoms, which have include fever over 100 degrees F, shivering, chills, fatigue, and malaise.[Ref]
Nervous system side effects have included headache, dizziness, asthenia, and paresthesia. In addition, acute hemiplegia and hemiparesis occurred in patients with central nervous system metastases one to three days following thyrotropin alfa treatment. Postmarketing side effects include spontaneous reports of stroke or unilateral weakness.[Ref]
Other side effects have included rare reports of events leading to death occurring within 24 hours after thyrotropin alpha administration.
A 77 year-old non-thyroidectomized patient with a history of heart disease and spinal metastases who received 4 thyrotropin alfa injections over 6 days in a special treatment protocol experienced a fatal MI 24 hours after he received the last injection. The event was likely related to thyrotropin alfa -induced hyperthyroidism.
Oncologic side effects have included sudden, rapid and painful enlargement of locally recurring papillary carcinoma occurring within 12-48 hours of thyrotropin alpha administration.
Cardiovascular side effects reported postmarketing include atrial arrhythmias in elderly patients with pre-existing cardiac disease.
Hypersensitivity side effects include very rare manifestations of hypersensitivity (urticaria, rash, pruritus, flushing and respiratory signs and symptoms) postmarketing in patients with advanced disease.
1. "Product Information. Thyrogen (thyrotropin alpha)." Genzyme Corporation, Cambridge, MA.
Some side effects of thyrotropin alpha may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
More about thyrotropin alpha
- Side Effects
- During Pregnancy
- Dosage Information
- Drug Interactions
- Support Group
- En Español
- 0 Reviews – Add your own review/rating
- Drug class: in vivo diagnostic biologicals
Other brands: Thyrogen
Related treatment guides
Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.