Skip to Content

Thyrotropin Alpha Dosage

Medically reviewed by Drugs.com. Last updated on Oct 30, 2020.

Applies to the following strengths: 1.1 mg

Usual Adult Dose for Thyroid Cancer

Two 1 mL (0.9 mg thyrotropin alpha) intramuscular injections into the buttock
-Administer second dose 24 hours after first

Comments:
-Drug stimulated thyroglobulin (Tg) levels are usually lower than, and do not correlate with, thyroid hormone withdrawal Tg levels.
-A missed thyroid cancer diagnosis or underestimation of disease extent can occur despite combination testing with radioiodine imaging.
-Anti-Tg antibodies may lead to uninterpretable Tg levels from Tg assays; consider further evaluating patients with negative or low-stage radioiodine scans.

Use: Adjunctive treatment for ablation in well differentiated thyroid cancer after thyroidectomy and without distant metastases

Usual Adult Dose for Diagnostic

Two 1 mL (0.9 mg thyrotropin alpha) intramuscular injections into the buttock
-Administer second dose 24 hours after first

Comments:
-Long term effects on thyroid cancer outcomes by use of this drug have not been determined.
-There is too little clinical data on use in remnant ablation to say if long term outcomes are equal to those of thyroid hormone withholding prior to ablation.

Use: Adjunctive diagnostic tool for serum thyroglobulin testing in well differentiated thyroid cancer after thyroidectomy

Renal Dose Adjustments

The manufacturer makes no recommendation regarding use in renal impairment.
-Elimination is significantly slower in dialysis dependent end stage renal disease.
-Thyroid stimulating hormone levels may be elevated for a prolonged time.

Liver Dose Adjustments

Data not available

Precautions

CONTRAINDICATIONS: None

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

The manufacturer makes no recommendation regarding use in dialysis.
-Elimination is significantly slower in dialysis dependent end stage renal disease.
-Thyroid stimulating hormone levels may be elevated for a prolonged time.

Other Comments

Administration advice:
-For intramuscular administration only.
-Do not administer intravenously.
-Consider corticosteroid pretreatment if tumor expansion could compromise vital organs.

Storage requirements:
-Refrigerate; protect from light

Reconstitution/preparation techniques:
-Add 1.2 mL sterile water for injection into vial.
-Swirl contents until completely dissolved; do not shake
-Use within 3 hours of reconstitution.
-Reconstituted product may be refrigerated for not more than 24 hours; avoid microbial contamination.
-Solution should be clear.
-Do not use if solution is discolored, cloudy, or has particulates.

IV compatibility:
-Do not mix with other substances.

General:
-Only for use by physicians knowledgeable in thyroid cancer treatment.

Monitoring:
-Routine TSH monitoring is NOT recommended after treatment.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.