Thyrotropin Alpha Dosage

Medically reviewed by Drugs.com. Last updated on Apr 19, 2022.

Applies to the following strengths: 0.9 mg

Usual Adult Dose for:

Thyroid Cancer
Diagnostic

Additional dosage information:

Renal Dose Adjustments
Liver Dose Adjustments
Precautions
Dialysis
Other Comments

Usual Adult Dose for Thyroid Cancer

Two 1 mL (0.9 mg thyrotropin alpha) intramuscular injections into the buttock

Administer second dose 24 hours after first

Comments:

Drug stimulated thyroglobulin (Tg) levels are usually lower than, and do not correlate with, thyroid hormone withdrawal Tg levels.
A missed thyroid cancer diagnosis or underestimation of disease extent can occur despite combination testing with radioiodine imaging.
Anti-Tg antibodies may lead to uninterpretable Tg levels from Tg assays; consider further evaluating patients with negative or low-stage radioiodine scans.

Use: Adjunctive treatment for ablation in well differentiated thyroid cancer after thyroidectomy and without distant metastases

Usual Adult Dose for Diagnostic

Two 1 mL (0.9 mg thyrotropin alpha) intramuscular injections into the buttock

Administer second dose 24 hours after first

Comments:

Long term effects on thyroid cancer outcomes by use of this drug have not been determined.
There is too little clinical data on use in remnant ablation to say if long term outcomes are equal to those of thyroid hormone withholding prior to ablation.

Use: Adjunctive diagnostic tool for serum thyroglobulin testing in well differentiated thyroid cancer after thyroidectomy

Renal Dose Adjustments

The manufacturer makes no recommendation regarding use in renal impairment.

Elimination is significantly slower in dialysis dependent end stage renal disease.
Thyroid stimulating hormone levels may be elevated for a prolonged time.

Liver Dose Adjustments

Data not available

Precautions

CONTRAINDICATIONS: None

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

The manufacturer makes no recommendation regarding use in dialysis.

Elimination is significantly slower in dialysis dependent end stage renal disease.
Thyroid stimulating hormone levels may be elevated for a prolonged time.

Other Comments

Administration advice:

For intramuscular administration only.
Do not administer intravenously.
Consider corticosteroid pretreatment if tumor expansion could compromise vital organs.

Storage requirements:

Refrigerate; protect from light

Reconstitution/preparation techniques:

Add 1.2 mL sterile water for injection into vial.
Swirl contents until completely dissolved; do not shake
Use within 3 hours of reconstitution.
Reconstituted product may be refrigerated for not more than 24 hours; avoid microbial contamination.
Solution should be clear.
Do not use if solution is discolored, cloudy, or has particulates.

IV compatibility: