Thiethylperazine Side Effects
Applies to thiethylperazine: intramuscular solution, oral tablet
Nervous system side effects have included sedation, dizziness, or headache. Extrapyramidal reactions have been reported in less than 1% of patients and included dystonia, torticollis, oculogyric crises, akathisia, and gait disturbances. Pseudo-parkinsonian reactions including mask-like facies, drooling, cogwheel rigidity, and shuffling gait have been reported. Convulsions have also been reported rarely. Neuroleptic malignant syndrome has been reported with other phenothiazines, and the potential to occur with thiethylperazine should be considered.[Ref]
Gastrointestinal side effects have included dryness of the mouth and nose, sialorrhea, and altered taste sensation.[Ref]
Hematologic side effects associated with phenothiazine derivatives have rarely included leukopenia, agranulocytosis, thrombocytopenia, aplastic anemia, pancytopenia, eosinophilia, and leukocytosis.[Ref]
Ocular side effects have included blurred vision.[Ref]
A 15-year-old female was admitted for angioedema and respiratory distress coincident with thiethylperazine therapy. She had been prescribed thiethylperazine (total of three doses) for abdominal pain and heavy nausea lasting for 2 days. Three hours after the last dose, she began to complain of face and tongue edema, speech difficulties, and dysphagia. On physical examination, she was in good general condition and showed an angioedema and erythema of the face, the upper thorax, and the tongue. An anaphylactic reaction was suspected and treatment was initiated. Her symptoms improved after treatment with intravenous biperiden, two aerosols of albuterol and budesonide, and intravenous methylprednisolone.[Ref]
1. "Product Information. Torecan (thiethylperazine)" Roxane Laboratories Inc, Columbus, OH.
2. Rossetti G, Livio F, Roulet E, Hofer MF "Anaphylactic reaction and unrelated, subsequent, known side effects during therapy with thiethylperazine." Pediatr Allergy Immunol 16 (2005): 453-5
More about thiethylperazine
- During Pregnancy or Breastfeeding
- Dosage Information
- Drug Interactions
- Drug class: phenothiazine antiemetics
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Some side effects may not be reported. You may report them to the FDA.