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Tarka Side Effects

Generic name: trandolapril / verapamil

Medically reviewed by Last updated on May 27, 2023.

Note: This document contains side effect information about trandolapril / verapamil. Some dosage forms listed on this page may not apply to the brand name Tarka.

Applies to trandolapril / verapamil: oral tablet extended release.


Oral route (Tablet, Extended Release)

Discontinue treatment with trandolapril/verapamil hydrochloride as soon as possible when pregnancy is detected, since fetal toxicity, including injury and death to the developing fetus, can be caused by drugs that act directly on the renin-angiotensin system.

Serious side effects of Tarka

Along with its needed effects, trandolapril / verapamil may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking trandolapril / verapamil:


Other side effects of Tarka

Some side effects of trandolapril / verapamil may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common or rare

For Healthcare Professionals

Applies to trandolapril / verapamil: oral tablet extended release.


The most common adverse reactions were headache, upper respiratory tract infection, cough, atrioventricular block first degree, constipation, and dizziness.[Ref]


Common (1% to 10%): Upper respiratory tract infection, cough, dyspnea, bronchitis, upper respiratory tract congestion

Frequency not reported: Epistaxis


Frequency not reported: Pulmonary edema[Ref]


Common (1% to 10%): Asthenia/weakness, chest pain, edema, fatigue

Frequency not reported: Malaise


Frequency not reported: Gynecomastia[Ref]


Common (1% to 10%): Constipation, nausea, diarrhea

Frequency not reported: Dyspepsia, dry mouth


Frequency not reported: Pancreatitis


Frequency not reported: Gingival hyperplasia, reversible nonobstructive paralytic ileus[Ref]


Common (1% to 10%): Pain back, pain extremity, pain joint

Frequency not reported: Arthralgias/myalgias[Ref]


Common (1% to 10%): Atrioventricular (AV) block first degree, bradycardia

Uncommon (0.1% to 1%): Hypotension

Frequency not reported: Angina, AV block second degree, bundle branch block, flushing, myocardial infarction, palpitation, premature ventricular contraction, nonspecific ST-T changes, tachycardia


Frequency not reported: Congestive heart failure, AV block third degree, AV dissociation, claudication, vasculitis[Ref]

Nervous system

There has been one postmarketing report of paralysis (tetraparesis) with verapamil, which may have been caused by concomitant use of colchicine.[Ref]

Common (1% to 10%): Headache, dizziness

Uncommon (0.1% to 1%): Near syncope

Frequency not reported: Drowsiness, hypesthesia, loss of balance, paresthesia, vertigo, tinnitus


Frequency not reported: Syncope, cerebrovascular accident, shakiness, somnolence

Postmarketing reports: Tetraparesis[Ref]


Common (1% to 10%): Creatinine increased

Uncommon (0.1% to 1%): BUN increased[Ref]


Common (1% to 10%): Hyperlipidemia

Frequency not reported: Gout, uric acid increased, hyperkalemia, hyponatremia[Ref]


Common (1% to 10%): Liver enzymes increased

Frequency not reported: Serum bilirubin increased[Ref]


Common (1% to 10%): Influenza[Ref]


Uncommon (0.1% to 1%): Angioedema

Frequency not reported: Pruritus, rash


Frequency not reported: Purpura, ecchymosis, exanthema, hair loss, hyperkeratosis, maculae, Stevens-Johnson syndrome, erythema multiform[Ref]


Frequency not reported: Impotence, endometriosis, hematuria, nocturia, polyuria, proteinuria


Frequency not reported: Urination increased, menstruation spotty[Ref]


Frequency not reported: Leukocytes decreased, neutrophils decreased, white blood cells low, neutrophils low, lymphocytes low, platelets low[Ref]


Frequency not reported: Insomnia, anxiety, mentation abnormal


Frequency not reported: Libido decreased


Frequency not reported: Confusion, psychotic symptoms[Ref]


Frequency not reported: Vision blurred[Ref]



Frequency not reported: Galactorrhea/hyperprolactinemia[Ref]


1. Product Information. Tarka (trandolapril-verapamil). Knoll Pharmaceutical Company. 2001;PROD.

2. Cerner Multum, Inc. UK Summary of Product Characteristics.

3. Cerner Multum, Inc. Australian Product Information.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.