Tarka Side Effects

Generic name: trandolapril / verapamil

Medically reviewed by Drugs.com. Last updated on Mar 8, 2025.

Note: This document provides detailed information about Tarka Side Effects associated with trandolapril / verapamil. Some dosage forms listed on this page may not apply specifically to the brand name Tarka.

Applies to trandolapril / verapamil: oral tablet extended release.

Precautions

It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly. Blood and urine tests may be needed to check for unwanted effects.

Using this medicine while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. If you think you have become pregnant while using this medicine, tell your doctor right away.

You should not use this medicine together with sacubitril. Do not use this medicine and sacubitril/valsartan (Entresto®) within 36 hours of each other.

Do not use this medicine at least 2 weeks before or 2 days after using flibanserin. Using these medicines together may cause serious unwanted effects.

This medicine may worsen the condition of patients with heart disease or heart rhythm problems. Check with your doctor right away if you have chest pain or tightness, decreased urine output, dilated neck veins, extreme fatigue, irregular heartbeat, swelling of the face, fingers, feet, or lower legs, troubled breathing, or weight gain. You might also feel dizzy or faint, or you might have a fast, pounding, or uneven heartbeat.

Dizziness, lightheadedness, or fainting may also occur, especially when you get up from a lying or sitting position or if you have been taking a diuretic (water pill). Do not drive or do anything else that could be dangerous until you know how this medicine affects you. If you feel dizzy, lie down so you do not faint. Then sit for a few moments before standing to prevent the dizziness from returning. If you faint, stop using this medicine and call your doctor right away.

Check with your doctor right away if you become sick while taking this medicine, especially with severe or continuing nausea, vomiting, or diarrhea. These conditions may cause you to lose too much water or salt and may lead to low blood pressure. You can also lose water by sweating, so drink plenty of water during exercise or in hot weather.

Check with your doctor right away if you have pain or tenderness in the upper stomach, dark urine, pale stools, nausea, vomiting, loss of appetite, or yellow skin or eyes. These could be symptoms of a serious liver problem.

This medicine may cause serious allergic reactions, including anaphylaxis. This can be life-threatening and requires immediate medical attention. Call your doctor right away if you have a rash, itching, hoarseness, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth while you are using this medicine.

Check with your doctor if you have a fever, chills, or sore throat. These may be symptoms of an infection resulting from low white blood cells.

Check with your doctor right away if you have bloody urine, a decrease in frequency or amount of urine, an increase in blood pressure, increased thirst, loss of appetite, lower back or side pain, nausea, swelling of the face, fingers, or lower legs, troubled breathing, unusual tiredness or weakness, vomiting, or weight gain. These could be symptoms of a serious kidney problem.

Hyperkalemia (high potassium in the blood) may occur while you are using this medicine. Check with your doctor right away if you have the following symptoms: abdominal or stomach pain, confusion, difficulty with breathing, irregular heartbeat, nausea or vomiting, nervousness, numbness or tingling in the hands, feet, or lips, shortness of breath, or weakness or heaviness of the legs. Ask your doctor before you use any medicine, supplement, or salt substitute containing potassium.

Make sure any doctor or dentist who treats you knows that you are using this medicine. This medicine could affect surgery or medical procedures.

Do not take other medicines unless they have been discussed with your doctor. This especially includes prescription or nonprescription (over-the-counter [OTC]) medicines for appetite control, asthma, colds, cough, hay fever, or sinus problems, and herbal or vitamin supplements, since they may increase your blood pressure.

Serious side effects of Tarka

Along with its needed effects, trandolapril / verapamil may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking trandolapril / verapamil:

Other side effects of Tarka

Some side effects of trandolapril / verapamil may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

For healthcare professionals

Applies to trandolapril / verapamil: oral tablet extended release.

General adverse events

The most common adverse reactions were headache, upper respiratory tract infection, cough, atrioventricular block first degree, constipation, and dizziness.^[Ref]

Respiratory

• Common (1% to 10%): Upper respiratory tract infection, cough, dyspnea, bronchitis, upper respiratory tract congestion
• Frequency not reported: Epistaxis

Verapamil:

• Frequency not reported: Pulmonary edema^[Ref]

Other

• Common (1% to 10%): Asthenia/weakness, chest pain, edema, fatigue
• Frequency not reported: Malaise

Verapamil:

• Frequency not reported: Gynecomastia^[Ref]

Gastrointestinal

• Common (1% to 10%): Constipation, nausea, diarrhea
• Frequency not reported: Dyspepsia, dry mouth

Trandolapril:

• Frequency not reported: Pancreatitis

Verapamil:

• Frequency not reported: Gingival hyperplasia, reversible nonobstructive paralytic ileus^[Ref]

Musculoskeletal

• Common (1% to 10%): Pain back, pain extremity, pain joint
• Frequency not reported: Arthralgias/myalgias^[Ref]

Cardiovascular

• Common (1% to 10%): Atrioventricular (AV) block first degree, bradycardia
• Uncommon (0.1% to 1%): Hypotension
• Frequency not reported: Angina, AV block second degree, bundle branch block, flushing, myocardial infarction, palpitation, premature ventricular contraction, nonspecific ST-T changes, tachycardia

Verapamil:

• Frequency not reported: Congestive heart failure, AV block third degree, AV dissociation, claudication, vasculitis^[Ref]

Nervous system

• Common (1% to 10%): Headache, dizziness
• Uncommon (0.1% to 1%): Near syncope
• Frequency not reported: Drowsiness, hypesthesia, loss of balance, paresthesia, vertigo, tinnitus

Verapamil:

• Frequency not reported: Syncope, cerebrovascular accident, shakiness, somnolence
• Postmarketing reports: Tetraparesis^[Ref]

There has been one postmarketing report of paralysis (tetraparesis) with verapamil, which may have been caused by concomitant use of colchicine.^[Ref]

Renal

• Common (1% to 10%): Creatinine increased
• Uncommon (0.1% to 1%): BUN increased^[Ref]

Metabolic

• Common (1% to 10%): Hyperlipidemia
• Frequency not reported: Gout, uric acid increased, hyperkalemia, hyponatremia^[Ref]

Hepatic

• Common (1% to 10%): Liver enzymes increased
• Frequency not reported: Serum bilirubin increased^[Ref]

Immunologic

• Common (1% to 10%): Influenza^[Ref]

Dermatologic

• Uncommon (0.1% to 1%): Angioedema
• Frequency not reported: Pruritus, rash

Verapamil:

• Frequency not reported: Purpura, ecchymosis, exanthema, hair loss, hyperkeratosis, maculae, Stevens-Johnson syndrome, erythema multiform^[Ref]

Genitourinary

• Frequency not reported: Impotence, endometriosis, hematuria, nocturia, polyuria, proteinuria

Verapamil:

• Frequency not reported: Urination increased, menstruation spotty^[Ref]

Hematologic

• Frequency not reported: Leukocytes decreased, neutrophils decreased, white blood cells low, neutrophils low, lymphocytes low, platelets low^[Ref]

Psychiatric

• Frequency not reported: Insomnia, anxiety, mentation abnormal

Trandolapril:

• Frequency not reported: Libido decreased

Verapamil:

• Frequency not reported: Confusion, psychotic symptoms^[Ref]

Ocular

• Frequency not reported: Vision blurred^[Ref]

Endocrine

Verapamil:

• Frequency not reported: Galactorrhea/hyperprolactinemia^[Ref]

See also:

Further information

Tarka side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

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