Tapinarof Topical Side Effects

Medically reviewed by Drugs.com. Last updated on Apr 8, 2025.

Applies to tapinarof topical: topical application cream.

Precautions

It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly and to check for any unwanted effects.

If your condition does not improve or if it becomes worse, check with your doctor.

Serious side effects of tapinarof topical

Along with its needed effects, tapinarof topical may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking tapinarof topical:

For healthcare professionals

Applies to tapinarof topical: topical cream.

General adverse events

The most frequently reported adverse events included folliculitis and nasopharyngitis.^[Ref]

Respiratory

• Very common (10% or more): Nasopharyngitis (11%)
• Common (1% to 10%): Influenza^[Ref]

Dermatologic

• Very common (10% or more): Folliculitis (20%)
• Common (1% to 10%): Contact dermatitis, pruritus, urticaria
• Uncommon (0.1% to 1%): Drug eruption^[Ref]

Adverse events which resulted in treatment discontinuation in greater than 1% of subjects were contact dermatitis (2.9%) and folliculitis (2.8%).^[Ref]

Nervous system

• Common (1% to 10%): Headache^[Ref]

See also:

Further information

Tapinarof topical side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer