Starlix Side Effects
Generic Name: nateglinide
Note: This page contains side effects data for the generic drug nateglinide. It is possible that some of the dosage forms included below may not apply to the brand name Starlix.
For the Consumer
Applies to nateglinide: oral tablet
As well as its needed effects, nateglinide (the active ingredient contained in Starlix) may cause unwanted side effects that require medical attention.
Major Side Effects
If any of the following side effects occur while taking nateglinide, check with your doctor immediately:Less common:
- Convulsions (seizures)
If any of the following side effects occur while taking nateglinide, check with your doctor or nurse as soon as possible:Less common:
- Low blood sugar, including anxious feeling, behavior change similar to being drunk, blurred vision, cold sweats, confusion, cool pale skin, difficulty in thinking, drowsiness, excessive hunger, fast heartbeat, headache, nausea, nervousness, nightmares, restless sleep, shakiness, slurred speech, or unusual tiredness or weakness
- Hives or welts
- redness of skin
- skin rash
Minor Side Effects
Some nateglinide side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:More common:
- runny or stuffy nose
- sore throat
- Abdominal or stomach pain
- back pain
- pain in joints or muscles
- swelling in joints
For Healthcare Professionals
Applies to nateglinide: oral tablet
The most frequently reported adverse events included upper respiratory tract infections and symptoms of hypoglycemia.[Ref]
Common (1% to 10%): Hypoglycemia
Frequency not reported: Increases in mean uric acid level[Ref]
Hypoglycemia has been reported and has generally been mild and corrected by intake of carbohydrates. In comparative clinical trials, hypoglycemia was reported in 10.4%, 14.5%, 6.9%, 19.8%, and 4.1% in patients receiving nateglinide alone, nateglinide plus metformin, metformin alone, glyburide alone, and placebo, respectively.
Mean uric acid levels were increased in patient receiving this drug as monotherapy. The difference from placebo in treated patients was 0.29 mg/dL, 0.45 mg/dL, 0.28 mg/dL, and 0.19 mg/dL in patients receiving nateglinide alone, nateglinide plus metformin, metformin alone, glyburide alone, respectively. The clinical significance of these findings is unknown.[Ref]
Common (1% to 10%): Upper respiratory tract infection, bronchitis, coughing[Ref]
Postmarketing reports: Hypersensitivity reactions such as rash, itching, and urticaria[Ref]
Common (1% to 10%): Diarrhea, abdominal pain, dyspepsia, nausea
Uncommon (0.1% to 1%): Vomiting[Ref]
Gastrointestinal symptoms, especially diarrhea and nausea, were no more common in patients using this drug in combination with metformin than in patients receiving metformin alone.[Ref]
Postmarketing reports: Elevated liver enzymes, jaundice, cholestatic hepatitis[Ref]
Common (1% to 10%): Dizziness[Ref]
Common (1% to 10%): Back pain, arthropathy[Ref]
Peripheral edema was no more common in patients using this drug in combination with rosiglitazone than in patients receiving rosiglitazone alone.[Ref]
Frequency not reported: Peripheral edema[Ref]
Postmarketing reports: Erythema multiforme[Ref]
Common (1% to 10%): Flu symptoms[Ref]
Common (1% to 10%): Accidental trauma[Ref]
1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
2. "Product Information. Starlix (nateglinide)" Novartis Pharmaceuticals, East Hanover, NJ.
3. Cerner Multum, Inc. "Australian Product Information." O 0
It is possible that some side effects of Starlix may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.
More about Starlix (nateglinide)
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