Starlix Side Effects
Generic Name: nateglinide
Note: This document contains side effect information about nateglinide. Some of the dosage forms listed on this page may not apply to the brand name Starlix.
For the Consumer
Applies to nateglinide: oral tablet
Along with its needed effects, nateglinide (the active ingredient contained in Starlix) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking nateglinide:Less common
- Convulsions (seizures)
Check with your doctor as soon as possible if any of the following side effects occur while taking nateglinide:Less common
- Low blood sugar, including anxious feeling, behavior change similar to being drunk, blurred vision, cold sweats, confusion, cool pale skin, difficulty in thinking, drowsiness, excessive hunger, fast heartbeat, headache, nausea, nervousness, nightmares, restless sleep, shakiness, slurred speech, or unusual tiredness or weakness
Some side effects of nateglinide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:More common
- runny or stuffy nose
- sore throat
- Abdominal or stomach pain
- back pain
- pain in joints or muscles
- swelling in joints
For Healthcare Professionals
Applies to nateglinide: oral tablet
Common (1% to 10%): Hypoglycemia
Frequency not reported: Increases in mean uric acid level[Ref]
Hypoglycemia has been reported and has generally been mild and corrected by intake of carbohydrates. In comparative clinical trials, hypoglycemia was reported in 10.4%, 14.5%, 6.9%, 19.8%, and 4.1% in patients receiving nateglinide alone, nateglinide plus metformin, metformin alone, glyburide alone, and placebo, respectively.
Mean uric acid levels were increased in patient receiving this drug as monotherapy. The difference from placebo in treated patients was 0.29 mg/dL, 0.45 mg/dL, 0.28 mg/dL, and 0.19 mg/dL in patients receiving nateglinide alone, nateglinide plus metformin, metformin alone, glyburide alone, respectively. The clinical significance of these findings is unknown.[Ref]
Gastrointestinal symptoms, especially diarrhea and nausea, were no more common in patients using this drug in combination with metformin than in patients receiving metformin alone.[Ref]
Common (1% to 10%): Dizziness[Ref]
Common (1% to 10%): Back pain, arthropathy[Ref]
Frequency not reported: Peripheral edema[Ref]
Common (1% to 10%): Flu symptoms[Ref]
Common (1% to 10%): Accidental trauma[Ref]
1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
2. "Product Information. Starlix (nateglinide)" Novartis Pharmaceuticals, East Hanover, NJ.
3. Cerner Multum, Inc. "Australian Product Information." O 0
Some side effects of Starlix may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
More about Starlix (nateglinide)
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- Drug class: meglitinides
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