Skip to main content

Sprycel Side Effects

Generic name: dasatinib

Medically reviewed by Last updated on Aug 13, 2021.

Note: This document contains side effect information about dasatinib. Some of the dosage forms listed on this page may not apply to the brand name Sprycel.

In Summary

Common side effects of Sprycel include: pericardial effusion, pleural effusion, pulmonary edema, dyspnea, fluid retention, and gastrointestinal hemorrhage. Other side effects include: anasarca. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to dasatinib: oral tablet

Side effects requiring immediate medical attention

Along with its needed effects, dasatinib (the active ingredient contained in Sprycel) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking dasatinib:

More common

  • Bleeding gums
  • bloody or black, tarry stools
  • body aches or pain
  • burning, tingling, numbness, or pain in the hands, arms, feet, or legs
  • chest pain or tightness
  • chills
  • constipation
  • cough
  • coughing up blood
  • decrease in the amount of urine
  • dizziness
  • ear congestion
  • fainting
  • fast, slow, or irregular heartbeat
  • fever
  • full or bloated feeling
  • headache
  • hoarseness
  • increased menstrual flow or vaginal bleeding
  • loss of voice
  • lower back or side pain
  • noisy or rattling breathing
  • nosebleeds
  • painful or difficult urination
  • pale skin
  • paralysis
  • pressure in the stomach
  • prolonged bleeding from cuts
  • red or dark brown urine
  • runny or stuffy nose
  • sensation of pins and needles
  • severe stomach pain
  • sneezing
  • sore throat
  • stabbing pain
  • swelling of the stomach area
  • swelling of the face, fingers, hands, feet, or lower legs
  • trouble breathing
  • ulcers, sores, or white spots in the mouth
  • unsteadiness or awkwardness
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • vomiting of blood or material that looks like coffee grounds
  • weakness in the arms, hands, legs, or feet
  • weight gain

Less common

  • Blue lips and fingernails
  • chest discomfort
  • coughing that sometimes produces a pink frothy sputum
  • difficult or fast breathing
  • dilated neck veins
  • increased sweating
  • irregular breathing
  • nausea
  • swelling in the legs and ankles

Incidence not known

  • Anxiety
  • blistering, peeling, or loosening of the skin
  • blurred vision
  • cloudy or bloody urine
  • diarrhea
  • itching
  • joint or muscle pain
  • nervousness
  • pain, redness, or swelling in the arm or leg
  • pounding in the ears
  • red skin lesions, often with a purple center
  • red, irritated eyes
  • sudden weakness in the arms or legs
  • sudden, severe chest pain
  • tenderness, pain, swelling, warmth, skin discoloration, and prominent superficial veins over the affected area

Side effects not requiring immediate medical attention

Some side effects of dasatinib may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Bone pain
  • cracked lips
  • difficulty with moving
  • difficulty with swallowing
  • lack or loss of strength
  • loss of appetite
  • muscle aching, cramping, or stiffness
  • pain
  • skin rash
  • stomach pain
  • swollen joints
  • vomiting
  • weight loss

For Healthcare Professionals

Applies to dasatinib: oral tablet


In the phase III dose optimization study in patients with chronic phase CML, grade 3 or 4 myelosuppression occurred more frequently in patients treated with the 70 mg twice daily regimen than in those treated with a 100 mg once daily regimen.[Ref]

Very common (10% or more): Hemorrhage (11 to 26%)

Common (1% to 10%): Febrile neutropenia, pancytopenia

Uncommon (0.1% to 1%): CNS bleeding

Rare (Less than 0.1%): Aplasia pure red cell[Ref]


The most common side effects included fluid retention, musculoskeletal pain, diarrhea, rash, and headache.[Ref]


Very common (10% or more): Diarrhea (18 to 31%), vomiting (11 to 16%), nausea (18 to 24%), abdominal pain (12%)

Common (1% to 10%): Enterocolitis infection, gastrointestinal bleeding, neutropenic colitis, gastritis, mucositis, stomatitis, dyspepsia, abdominal distension, constipation, oral soft tissue disorder

Uncommon (0.1% to 1%): Pancreatitis, upper gastrointestinal ulcer, esophagitis, ascites, anal fissure, dysphagia

Rare (Less than 0.1%): Protein-losing gastroenteropathy, ileus

Postmarketing reports: Fatal gastrointestinal hemorrhage[Ref]

Nervous system

Very common (10% or more): Headache (13 to 33%)

Common (1% to 10%): Neuropathy, peripheral neuropathy, dizziness, dysgeusia, somnolence

Uncommon (0.1% to 1%): Syncope, amnesia, tremor

Rare (Less than 0.1%): Cerebrovascular accident, transient ischemic attack, convulsion, optic neuritis, seventh nerve paralysis[Ref]


Very common (10% or more): Musculoskeletal pain (11 to 22%)

Common (1% to 10%): Arthralgia, myalgia, muscular weakness, musculoskeletal stiffness, muscle spasm, chills

Uncommon (0.1% to 1%): Rhabdomyolysis, muscle inflammation, tendonitis, blood creatine phosphokinase increased[Ref]


Very common (10% or more): Pleural effusion (11 to 24%), dyspnea (15 to 24%), cough

Common (1% to 10%): Pneumonia (including bacterial, viral, fungal), upper respiratory tract infection, pulmonary edema, pulmonary hypertension, lung infiltration, pneumonitis

Uncommon (0.1% to 1%): Bronchospasm, asthma

Rare (Less than 0.1%): Acute respiratory distress syndrome

Postmarketing reports: Pulmonary embolism, interstitial lung disease, pulmonary arterial hypertension[Ref]


Common (1% to 10%): Anorexia, appetite disturbances, hyperuricemia, weight decreased, weight increased

Uncommon (0.1% to 1%): Hypoalbuminemia[Ref]


Uncommon (0.1% to 1%): Hepatitis, cholecystitis, cholestasis[Ref]


Results from phase II single arm clinical studies of 911 patients reported QT prolongation in 9 patients. Three patients (less than 1%) experienced a QTcF greater than 500 milliseconds.

In the phase III dose optimization study in patients with chronic phase CML, pleural effusion and congestive cardiac failure/cardiac dysfunction occurred more frequently in the 70 mg twice a day regimen than in those treated with a 100 mg once daily regimen.[Ref]

Common (1% to 10%): Congestive heart failure, cardiac dysfunction, pericardial effusion, arrhythmia, tachycardia, palpitations, hypertension, chest pain

Uncommon (0.1% to 1%): Myocardial infarction, electrocardiogram QT prolongation, pericarditis, ventricular arrhythmia, ventricular tachycardia, angina pectoris, cardiomegaly, hypotension

Rare (less than 0.1%): Cor pulmonale, myocarditis, acute coronary syndrome

Postmarketing reports: Atrial fibrillation, atrial flutter[Ref]


Very common (10% or more): Skin rash (15 to 21%)

Common (1% to 10%): Flushing, alopecia, dermatitis, eczema, pruritus, acne, dry skin, urticaria, hyperhidrosis, contusion

Uncommon (0.1% to 1%): Acute febrile neutrophilic dermatosis, photosensitivity, pigmentation disorder, panniculitis, skin ulcer, bullous conditions, nail disorder, palmar-plantar erythrodysesthesia syndrome

Rare (Less than 0.1%): Livedo reticularis[Ref]


Very common (10% or more): Fluid retention (21 to 42%)

Uncommon (0.1% to 1%): Renal failure, urinary frequency, proteinuria[Ref]


Very common (10% or more): Fatigue (19 to 26%), superficial edema (10 to 21%), pyrexia (11 to 18%)

Common (1% to 10%): Tinnitus, pain, generalized edema, asthenia

Uncommon (0.1% to 10%): Vertigo, thrombophlebitis, gynecomastia, irregular menstruation, malaise, temperature intolerance

Postmarketing reports: Deep vein thrombosis[Ref]


Common (1% to 10%): Depression, insomnia

Uncommon (0.1% to 1%): Anxiety, confusion, affect lability, libido decreased[Ref]


Uncommon (0.1% to 1%): Erythema nodosum, unspecified hypersensitivity reaction[Ref]


Common (1% to 10%): Visual disturbance, blurred vision, reduction in visual acuity, dry eye

Uncommon (0.1% to 1%): Conjunctivitis

Rare (Less than 0.1%): Visual impairment[Ref]


Uncommon (0.1% to 1%): Tumor lysis syndrome[Ref]


Very common (10% or more): Infection (including bacterial, viral, fungal, non-specified) (10 to 14%)

Common (1% to 10%): Sepsis[Ref]

Frequently asked questions


1. "Product Information. Sprycel (dasatinib)." Bristol-Myers Squibb, Princeton, NJ.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.