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BCR-ABL tyrosine kinase inhibitors

What are BCR-ABL tyrosine kinase inhibitors?

BCR-ABL tyrosine kinase inhibitors inhibit the enzyme BCR-ABL tyrosine kinase, which is important in the pathogenesis of chronic myelogenous leukemia (CML).

Chronic myelogenous leukemia occurs due a single genetic abnormality, known as the Philadelphia chromosome. During the translocation when the Philadelphia chromosome is created, a fusion gene called BCR-ABL gene is formed. The BCR-ABL gene encodes for the BCR-ABL tyrosine kinase. The BCR-ABL positive cells in chronic myelogenous leukemia have increased proliferation and resistance to cell death.

BCR-ABL tyrosine kinase inhibitors are used to treat chronic myelogenous leukemia.

List of BCR-ABL tyrosine kinase inhibitors:

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Drug Name Reviews Avg. Ratings
Gleevec (Pro)
generic name: imatinib
31 reviews
   
8.8
Sprycel (Pro)
generic name: dasatinib
15 reviews
   
8.5
Tasigna (Pro)
generic name: nilotinib
20 reviews
   
7.8
Bosulif (Pro)
generic name: bosutinib
4 reviews
   
7.0
Iclusig (Pro)
generic name: ponatinib
2 reviews
   
3.0

Further information

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