BCR-ABL tyrosine kinase inhibitors
What are BCR-ABL tyrosine kinase inhibitors?
BCR-ABL tyrosine kinase inhibitors inhibit the enzyme BCR-ABL tyrosine kinase, which is important in the pathogenesis of chronic myelogenous leukemia (CML).
Chronic myelogenous leukemia occurs due a single genetic abnormality, known as the Philadelphia chromosome. During the translocation when the Philadelphia chromosome is created, a fusion gene called BCR-ABL gene is formed. The BCR-ABL gene encodes for the BCR-ABL tyrosine kinase. The BCR-ABL positive cells in chronic myelogenous leukemia have increased proliferation and resistance to cell death.
BCR-ABL tyrosine kinase inhibitors are used to treat chronic myelogenous leukemia.
List of BCR-ABL tyrosine kinase inhibitors:
View by: Brand | Generic
|Drug Name||Reviews||Avg. Ratings|
Generic name: imatinib
|31 reviews|| |
Generic name: dasatinib
|15 reviews|| |
Generic name: nilotinib
|20 reviews|| |
Generic name: bosutinib
|4 reviews|| |
Generic name: ponatinib
|2 reviews|| |
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Medical conditions associated with BCR-ABL tyrosine kinase inhibitors: