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Salflex Side Effects

Generic Name: salsalate

Note: This page contains side effects data for the generic drug salsalate. It is possible that some of the dosage forms included below may not apply to the brand name Salflex.

For the Consumer

Applies to salsalate: oral tablet

Get emergency medical help if you have any of these signs of an allergic reaction while taking salsalate (the active ingredient contained in Salflex) hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using this medication and call your doctor at once if you have a serious side effect such as:

  • chest pain, severe dizziness, shortness of breath, slurred speech, problems with vision or balance;

  • sudden numbness or weakness, especially on one side of the body;

  • feeling like you might pass out;

  • black, bloody, or tarry stools;

  • coughing up blood or vomit that looks like coffee grounds;

  • hearing problems, ringing in your ears;

  • swelling in your hands or feet, rapid weight gain;

  • fast or pounding heartbeats;

  • easy bruising or bleeding, fever, chills, sore throat, flu symptoms;

  • urinating more or less than usual;

  • severe stomach pain, ongoing nausea or vomiting; or

  • dark urine, jaundice (yellowing of the skin or eyes).

Less serious side effects of salsalate may include:

  • upset stomach, heartburn; or

  • mild dizziness.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For Healthcare Professionals

Applies to salsalate: oral capsule, oral tablet


Gastrointestinal side effects including abdominal pain, diarrhea, nausea, and GI bleeding have been frequently reported.[Ref]


Hepatic side effects including abnormal hepatic function and hepatitis have been reported.[Ref]


Cardiovascular side effects including angioedema and hypotension have been reported.[Ref]


Renal side effects including decreased creatinine clearance, nephritis, and urticaria have been reported.[Ref]


Respiratory side effects including bronchospasm have been reported.[Ref]


Other side effects including tinnitus, hearing impairment, vertigo, rash, and anaphylactic shock have been reported.[Ref]


1. "Product Information. Disalcid (salsalate)." 3M Pharmaceuticals, St. Paul, MN.

2. Phillips BB, Joss JD, Mulhausen PL "Blood pressure elevation in a patient treated with salsalate." Ann Pharmacother 36 (2002): 624-7

It is possible that some side effects of Salflex may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.