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Rocuronium Side Effects

Medically reviewed by Last updated on Aug 23, 2022.

Applies to rocuronium: intravenous solution.

Serious side effects of Rocuronium

Along with its needed effects, rocuronium may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking rocuronium:


  • Cough
  • difficulty with breathing
  • dizziness
  • fainting
  • fast, slow, or irregular heartbeat
  • noisy breathing
  • swelling at the injection site
  • tightness in the chest

Incidence not known

  • Difficulty with swallowing
  • hives, itching, or skin rash
  • muscular pain, tenderness, wasting, or weakness
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • unusual tiredness or weakness

For Healthcare Professionals

Applies to rocuronium: intravenous solution.


Uncommon (0.1% to 1%): Arrhythmia, abnormal electrocardiogram, tachycardia

Rare (0.01% to 0.1%): Hypotension, hypertension

Very rare (less than 0.01%): Circulatory collapse and shock, flushing[Ref]


Rare (0.01% to 0.1%): Injection site edema, pruritus

Very rare (less than 0.01%): Angioneurotic edema, urticaria, rash, erythematous rash[Ref]


Uncommon (0.1% to 1%): Nausea, vomiting[Ref]


Very rare (less than 0.01%): Hypersensitivity, anaphylactic reaction, anaphylactoid reaction, anaphylactic shock, anaphylactoid shock[Ref]


Uncommon (0.1% to 1%): Asthma (bronchospasm, wheezing, or rhonchi), hiccup

Very rare (less than 0.01%): Bronchospasm

Postmarketing reports: Increased pulmonary vascular resistance[Ref]


Rare (less than 0.1%): Injection site pain, injection site reaction[Ref]


Rare (less than 0.1%): Prolonged neuromuscular block

Very rare (less than 0.01%): Muscular weakness

Frequency not reported: Residual paralysis, myopathy[Ref]

Nervous system

Very rare (less than 0.01%): Flaccid paralysis[Ref]


Uncommon (0.1% to 1%): Drug ineffective, drug effect/therapeutic response decreased, drug effect/therapeutic response increased

Frequency not reported: Malignant hyperthermia[Ref]


1. "Product Information. Zemuron (rocuronium)." Organon (2001):

2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

3. Pharmaceutical Society of Australia "APPGuide online. Australian prescription products guide online." (2006):

4. "Product Information. Rocuronium Bromide (rocuronium)." Hospira Inc (2019):

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.