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Rocuronium Dosage

Applies to the following strength(s): 10 mg/mL ; 50 mg/5 mL ; 100 mg/10 mL

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Anesthesia

TRACHEAL INTUBATION: Recommended initial dose is 0.6 mg/kg IV
RAPID SEQUENCE INTUBATION: 0.6 to 1.2 mg/kg IV

Maintenance doses: Guided by response to prior dose, not administered until recovery is evident.

Continuous infusion: Initial rate of 10 to 12 mcg/kg/min IV. Start only after early evidence of spontaneous recovery from an intubating dose.

Comments:
-Dosing information is derived from studies based upon units of drug per unit of body weight. It is intended to serve as an initial guide to clinicians familiar with other neuromuscular blocking agents to acquire experience with this drug. More information may be obtained by consulting the manufacturer product information.
-As with other neuromuscular blocking agents, the dosage of this drug should be individualized in each patient. The method of anesthesia, expected duration of surgery, method of sedation, expected duration of mechanical ventilation, possible interaction with other drugs that are administered concomitantly, and the condition of the patient should be taken into account when determining the dose.
-The use of an appropriate neuromuscular monitoring technique is recommended for the evaluation of neuromuscular block and recovery.

Use: For inpatients and outpatients as an adjunct to general anesthesia to facilitate both rapid sequence and routine tracheal intubation, and to provide skeletal muscle relaxation during surgery or mechanical ventilation.

Usual Pediatric Dose for Anesthesia

Infants and children:
TRACHEAL INTUBATION: 0.45 to 0.6 mg/kg IV
Maintenance for continued surgical relaxation, bolus: 0.075 to 0.125 mg/kg IV
Maintenance for continued surgical relaxation, continuous infusion: 7 to 12 mcg/kg/min IV

Comments:
-Dosing information is derived from studies based upon units of drug per unit of body weight. It is intended to serve as an initial guide to clinicians familiar with other neuromuscular blocking agents to acquire experience with this drug. More information may be obtained by consulting the manufacturer product information.
-As with other neuromuscular blocking agents, the dosage of this drug should be individualized in each patient. The method of anesthesia, expected duration of surgery, method of sedation, expected duration of mechanical ventilation, possible interaction with other drugs that are administered concomitantly, and the condition of the patient should be taken into account when determining the dose.
-The use of an appropriate neuromuscular monitoring technique is recommended for the evaluation of neuromuscular block and recovery.
-The experience with this drug in rapid sequence induction in pediatric patients is limited. This drug is therefore not recommended for facilitating tracheal intubation conditions during rapid sequence induction in pediatric patients.

Use: For tracheal intubation during routine sequence induction

Renal Dose Adjustments

No adjustment recommended

Liver Dose Adjustments

The manufacturer recommends caution

Precautions

This drug is not recommended for use in children for rapid sequence tracheal intubation.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

General:
-This drug should only be administered by experienced clinicians or trained individuals supervised by an experienced clinician familiar with the use, actions, characteristics, and complications of neuromuscular blocking agents. Doses should be individualized and a peripheral nerve stimulator should be used to monitor drug effect, need for additional doses, adequacy of spontaneous recovery or antagonism, and to decrease the complications of overdosage if additional doses are administered.
-This drug, which has an acid pH, should not be mixed with alkaline solutions (e.g., barbiturate solutions) in the same syringe or administered simultaneously during intravenous infusion through the same needle.
-If extravasation occurs, it may be associated with signs or symptoms of local irritation. The injection or infusion should be terminated immediately and restarted in another vein.

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