Skip to main content

Renese-R Side Effects

Generic name: polythiazide / reserpine

Note: This document contains side effect information about polythiazide / reserpine. Some dosage forms listed on this page may not apply to the brand name Renese-R.

Applies to polythiazide / reserpine: oral tablet.


A woman with paroxysmal atrial tachycardia developed sinus pauses during reserpine therapy which were reproducible by carotid massage, except when isoproterenol was given. Reserpine is known to increase vagal tone and to deplete cardiac catecholamines.[Ref]

Cardiovascular side effects include hypotension in 8% and bradycardia in 3% of patients. Some patients who develop hypotension or bradycardia experience syncope. This may be more likely in elderly patients. Cardiac arrhythmias, including ventricular ectopy and complete AV heart block, have been associated with thiazide-induced hypokalemia. A rare case of paroxysmal atrial tachycardia with block associated with reserpine in a patient who was not taking a digitalis preparation has been reported.[Ref]


Metabolic side effects of polythiazide, as with other thiazide diuretics, include hypokalemia, hyponatremia, hypochloremia, hypercalcemia, hypercholesterolemia, and hyperuricemia. Significant reductions in the serum potassium concentration (decreases of 0.5 mEq/L or more) have been observed in up to 50% of patients who are taking moderate doses of thiazide diuretics. This reduction in serum potassium can predispose some patients to develop cardiac arrhythmias.[Ref]

Some of the metabolic changes associated with thiazide diuretics may be significant in patients with underlying cardiac arrhythmias (hypokalemia), coronary artery disease (hypercholesterolemia), gout (hyperuricemia), or liver disease (hyponatremia and hypokalemia).[Ref]


Rare reports of reserpine-induced bronchospasm are believed to be due to inactivation of beta-adrenergic receptors, which can result in a marked potentiation of the bronchoconstrictive effect of histamine.[Ref]

Respiratory side effects including nasal congestion occurs in 8% of patients who are taking reserpine. A rare respiratory system side effect associated with reserpine is bronchospasm.[Ref]

Nervous system

Nervous system side effects associated with reserpine include sedation, lethargy (different from the psychiatric syndrome of depression). drowsiness, weakness, vertigo, insomnia, or headache in approximately 1% to 5% of patients. While reserpine is used to treat tardive dyskinesia, extrapyramidal movements may worsen upon withdrawal of therapy. A case of CNS hypertension, believed to be due to cerebral edema, has been associated with reserpine.[Ref]

Increased parkinsonian movements upon reserpine withdrawal (as with neuroleptics) may be due to supersensitivity to dopamine as a result of increased dopamine receptors that developed during reserpine therapy.[Ref]


Hypersensitivity reactions to thiazide diuretics have been reported in less than 1% of patients. While most allergic reactions present as rash with nausea and vomiting, rare cases of acute pulmonary edema, interstitial cystitis, interstitial nephritis, and anaphylaxis have been associated with some thiazide diuretics.[Ref]


The depressive syndrome usually consists of melancholy, loss of self confidence, early morning awakening, loss of libido, and reduced appetite.

A case of reserpine withdrawal psychosis has been reported. This uncommon condition may be due to dopamine receptor supersensitivity, which may develop during reserpine therapy.[Ref]

Psychiatric problems related to reserpine therapy can be serious. Depression occurs in 2% to 28% of patients, is more likely when daily doses exceed 0.5 mg, and can present at any time during therapy. Reserpine-induced suicidal ideation and withdrawal psychosis have been reported. Reserpine-induced depression is quickly reversible if therapy is withdrawn as soon as the syndrome is recognized, but can persist for several months after drug discontinuation if the syndrome fully develops. Limited data suggest an association between psychiatric depression and thiazide diuretics. These data are uncontrolled observations and have not been substantiated.[Ref]


Dermatologic reactions to thiazides include erythema annular centrifugum, acute eczematous dermatitis, and morbilliform and leukocytoclastic vasculitis. Thiazides may induce phototoxic dermatitis. In addition, a rare, distinct entity with clinical and laboratory features indistinguishable from those of subacute cutaneous lupus erythematosus has been associated with a related drug, hydrochlorothiazide.[Ref]


Thiazide diuretics may increase serum cholesterol and triglycerides, resulting in increased risk of cholesterol gallstone formation. Cases of bowel strictures associated with thiazide ingestion were reported in the 1960's, although these patients were on a combination hydrochlorothiazide-potassium product.[Ref]

Gastrointestinal side effects due to unopposed parasympathetic activity produced by catecholamine depletion may lead to increased gastrointestinal motility and secretory activity. Because of this, new diarrhea or worsening of existing diarrhea or increased salivation have been reported in 2% of patients. Increased appetite, abdominal pain, or vomiting have rarely been associated with reserpine. There have been rare cases of pancreatitis and acute cholecystitis associated with thiazide diuretics.[Ref]


Renal side effects including new or worsened renal insufficiency may occur due to polythiazide-induced intravascular volume depletion. Rare cases of interstitial nephritis have been associated with some thiazide diuretics.[Ref]


A prospective study of 34 patients who received oral thiazide diuretics for 14 years without interruption revealed an increased mean fasting blood glucose level after treatment. Withdrawal of thiazide therapy for 7 months in 10 of the patients resulted in mean reductions of 10% in fasting blood glucose and 25% in the 2-hour glucose tolerance test value. A control group was not reported.[Ref]

Endocrinologic problems have been associated with both drugs. Reserpine-induced hyperprolactinemia can result in gynecomastia in men and breast engorgement or pseudolactation in women. Thiazide diuretics can induce glucose intolerance and produce a potentially deleterious effect on the lipid profile. This may be important in some patients with or who are at risk for diabetes or coronary artery disease.[Ref]


Genitourinary complaints are limited to impotence, reported in approximately 5% of male patients who are taking reserpine.[Ref]


A 2.5-year-old male with anasarca developed cyanosis and oral ulcerations associated with laboratory evidence of pancytopenia 15 days after beginning polythiazide (dose not available). A bone marrow aspiration revealed general hypoplasia with absence of megakaryocytes and blast cells. The child died from persistent hemorrhaging and infections despite prednisolone and antimicrobial therapy.[Ref]

Hematologic side effects are rare. Cases of immune-complex hemolytic anemia, aplastic anemia, and thrombocytopenia have been associated either with polythiazide or related thiazide agents.[Ref]


Immunologic side effects are rare. A single case of angioimmunoloblastic lymphadenopathy has been associated with reserpine. In one study of 231 patients, only one case of a lupus-like syndrome was observed. The patient had previously received hydralazine.[Ref]

A 79-year-old woman with hypertension, who was taking reserpine, potassium, HCTZ, and ibuprofen, developed fatigue, anorexia, fever, night sweats, and weight loss. Associated laboratory findings showed anemia, lymphocytosis, thrombocytopenia, IgA kappa paraproteinemia, positive ANA, and a positive Coombs' test. Bone marrow biopsy, lymphangiography, and lymph node biopsy showed bone marrow lymphocytosis, enlarged foamy abdominal lymph nodes with irregular filling, and angioimmunoblastic lymphadenopathy. Within four days after discontinuation of reserpine (her other medications were continued), the paraprotein level normalized and the platelet count rose. After an additional nine months of prednisone therapy, all of her signs and symptoms resolved.[Ref]


Oncologic concerns were raised after a large drug surveillance center in Boston reported an association between reserpine, a stimulator of prolactin, and breast cancer. These data were partially, but not completely, confirmed in two similar centers in Europe. A critical review of these studies elucidated several design flaws. Subsequent, controlled studies failed to show an association between reserpine and an increased incidence of breast carcinoma.[Ref]


1. Papademetriou V, Fletcher R, Khatri IM, Freis ED. Diuretic-induced hypokalemia in uncomplicated systemic hypertension: effect of plasma potassium correction on cardiac arrhythmias. Am J Cardiol. 1983;52:1017-22.

2. Ragnarsson J, Hardarson T, Snorrason SP. Ventricular dysrhythmias in middle-aged hypertensive men treated either with a diuretic agent or a beta-blocker. Acta Med Scand. 1987;221:143-8.

3. Hollifield JW, Slaton PE. Thiazide diuretics, hypokalemia and cardiac arrhythmias. Acta Med Scand Suppl. 1981;647:67-73.

4. Krishna GG, Narins RG. Hemodynamic consequences of diuretic-induced hypokalemia. Am J Kidney Dis. 1988;12:329-31.

5. Mahabir RN, Laufer ST. Clinical evaluation of diuretics in congestive heart failure. A detailed study in four patients. Arch Intern Med. 1969;124:1-7.

6. Holland OB, Kuhnert L, Pollard J, Padia M, Anderson RJ, Blomqvist G. Ventricular ectopic activity with diuretic therapy. Am J Hypertens. 1988;1:380-5.

7. Mouallem M, Friedman E, Shemesh Y, Mayan H, Pauzner R, Farfel Z. Cardiac conduction defects associated with hyponatremia. Clin Cardiol. 1991;14:165-8.

8. Grunwald MH, Halevy S, Livni E. Allergic vasculitis induced by hydrochlorothiazide: confirmation by mast cell degranulation test. Isr J Med Sci. 1989;25:572-4.

9. Sharon E, Paolino JS, Kaplan D. Hematemesis after reserpine for Raynaud's phenomenon. Ann Intern Med. 1972;77:479-80.

10. Applegate WB, Carper ER, Kahn SE, Westbrook L, Linton M, Baker MG, Runyan JW, Jr. Comparison of the use of reserpine versus alpha-methyldopa for second step treatment of hypertension in the elderly. J Am Geriatr Soc. 1985;33:109-15.

11. Murayama M, Yasuda K, Minamori Y, Mercado-Asis LB, Yamakita N, Miura K. Long term follow-up of Cushing's disease treated with reserpine and pituitary irradiation. J Clin Endocrinol Metab. 1992;75:935-42.

12. Widmer RB. Reserpine: the maligned antihypertensive drug. J Fam Pract. 1985;20:81-3.

13. Combs RM. Unusual response to reserpine in paroxysmal atrial tachycardia with block unassociated with digitalis. South Med J. 1967;60:839-42.

14. Berlant JL. Neuroleptics and reserpine in refractory psychoses. J Clin Psychopharmacol. 1986;6:180-4.

15. Kirschenbaum HL, Rosenberg JM. What to look out for with guanethidine and reserpine. RN. 1984;47:31-3.

16. O'Brien ET, MacKinnon J. Propranolol and polythiazide in treatment of hypertension. Br Heart J. 1972;34:1042-4.

17. Marinkovic M, Vrhovac B, Kuzmanic D, Radonic M. Comparative study with prazosin, methyldopa and polythiazide in arterial hypertension. Int J Clin Pharmacol Biopharm. 1979;17:38-47.

18. Rosenberg L, Shapiro S, Slone D, Kaufman DW, Miettinen OS, Stolley PD. Thiazides and acute cholecystitis. N Engl J Med. 1980;303:546-8.

19. Kuller L, Farrier N, Caggiula A, Borhani N, Dunkle S. Relationship of diuretic therapy and serum magnesium levels among participants in the Multiple Risk Factor Intervention Trial. Am J Epidemiol. 1985;122:1045-59.

20. Fichman MP, Vorherr H, Kleeman CR, Telfer N. Diuretic-induced hyponatremia. Ann Intern Med. 1971;75:853-63.

21. Papademetriou V, Price M, Notargiacomo A, Gottdiener J, Fletcher RD, Freis ED. Effect of diuretic therapy on ventricular arrhythmias in hypertensive patients with or without left ventricular hypertrophy. Am Heart J. 1985;110:595-9.

22. Polanska AI, Baron DN. Hyponatraemia associated with hydrochlorothiazide treatment . Br Med J. 1978;1:175-6.

23. Pinnock CA. Hyponatraemia associated with hydrochlorothiazide treatment . Br Med J. 1978;1:48.

24. Hakim R, Tolis G, Goltzman D, Meltzer S, Friedman R. Severe hypercalcemia associated with hydrochlorothiazide and calcium carbonate therapy. Can Med Assoc J. 1979;121:591-4.

25. Byatt CM, Millard PH, Levin GE. Diuretics and electrolyte disturbances in 1000 consecutive geriatric admissions. J R Soc Med. 1990;83:704-8.

26. Bain PG, Egner W, Walker PR. Thiazide-induced dilutional hyponatraemia masquerading as subarachnoid haemorrhage . Lancet. 1986;2:634.

27. Benfield GF, Haffner C, Harris P, Stableforth DE. Dilutional hyponatraemia masquerading as subarachnoid haemorrhage in patient on hydrochlorothiazide/amiloride/timolol combined drug . Lancet. 1986;2:341.

28. Duarte CG, Winnacker JL, Becker KL, Pace A. Thiazide-induced hypercalcemia. N Engl J Med. 1971;284:828-30.

29. Gould L, Reddy CV, Zen B, Singh BK. Life-threatening reaction to thiazides. N Y State J Med. 1980;80:1975-6.

30. Diamond MT. Hyperglycemic hyperosmolar coma associated with hydrochlorothiazide and pancreatitis. N Y State J Med. 1972;72:1741-2.

31. Klimiuk PS, Davies M, Adams PH. Primary hyperparathyroidism and thiazide diuretics. Postgrad Med J. 1981;57:80-3.

32. Seelig CB. Magnesium deficiency in two hypertensive patient groups. South Med J. 1990;83:739-42.

33. Peters RW, Hamilton J, Hamilton BP. Incidence of cardiac arrhythmias associated with mild hypokalemia induced by low-dose diuretic therapy for hypertension. South Med J. 1989;82:966-9,.

34. Kone B, Gimenez L, Watson AJ. Thiazide-induced hyponatremia. South Med J. 1986;79:1456-7.

35. Fager G, Berglund G, Bondjers G, Elmfeldt D, Lager I, Olofsson SO, Smith U, Wiklund O. Effects of anti-hypertensive therapy on serum lipoproteins. Treatment with metoprolol, propranolol and hydrochlorothiazide. Artery. 1983;11:283-96.

36. Jones IG, Pickens PT. Diabetes mellitus following oral diuretics. Practitioner. 1967;199:209-10.

37. Kaur J, Wahi PL. Polythiazide as a diuretic. A clinical trial. J Indian Med Assoc. 1967;48:13-7.

38. Murphy MB, Kohner E, Lewis PJ, Schumer B, Dollery CT. Glucose intolerance in hypertensive patients treated with diuretics: a fourteen-year follow-up. Lancet. 1982;2:1293-5.

39. Bell DS. Insulin resistance. An often unrecognized problem accompanying chronic medical disorders. Postgrad Med. 1993;93:99-103,.

40. Berlin I. Prazosin, diuretics, and glucose intolerance. Ann Intern Med. 1993;119:860.

41. Nilsson G. Symptomatic diabetes mellitus cured by potassium and withdrawal of polythiazide in a hypokalemic hypertensive woman. Acta Med Scand. 1980;208:129-30.

42. Ghose RR. Reset osmostat after diuretic treatment. Br Med J. 1977;2:1063.

43. Smith WM. Diuretics and cholesterol elevation. JAMA. 1979;242:1612.

44. Ghose RR. Letter: Hyponatraemia and diuretics. Lancet. 1975;1:578-9.

45. Larson E, Dominguez CJ, Scheib R. Thiazide therapy: experience with parenteral administration. Curr Ther Res Clin Exp. 1965;7:617-24.

46. Mukerjee AB. Reserpine-frusemide and reserpine-polythiazide combinations in hypertension. J Indian Med Assoc. 1973;60:168-72.

47. Ramirez EA, Tristani FE. Clinical evaluation of parenteral polythiazide (P-2525) administration. Curr Ther Res Clin Exp. 1965;7:528-35.

48. Klein MD. Noncardiogenic pulmonary edema following hydrochlorothiazide ingestion. Ann Emerg Med. 1987;16:901-3.

49. Beaudry C, Laplante L. Severe allergic pneumonitis from hydrochlorothiazide. Ann Intern Med. 1973;78:251-3.

50. Hoegholm A, Rasmussen SW, Kristensen KS. Pulmonary oedema with shock induced by hydrochlorothiazide: a rare side effect mimicking myocardial infarction. Br Heart J. 1990;63:186.

51. Biron P, Dessureault J, Napke E. Acute allergic interstitial pneumonitis induced by hydrochlorothiazide [published erratum appears in Can Med Assoc J 1991 Sep 1;145(5):391]. Can Med Assoc J. 1991;145:28-34.

52. Dorn MR, Walker BK. Noncardiogenic pulmonary edema associated with hydrochlorothiazide therapy. Chest. 1981;79:482-3.

53. Prupas HM, Brown D. Acute idiosyncratic reaction to hydrochlorothiazide ingestion. West J Med. 1983;138:101-2.

54. Grace AA, Morgan AD, Strickland NH. Hydrochlorothiazide causing unexplained pulmonary oedema. Br J Clin Pract. 1989;43:79-81.

55. Levay ID. Hydrochlorothiazide-induced pulmonary edema. Drug Intell Clin Pharm. 1984;18:238-9.

56. Alted E, Navarro M, Cantalapiedra JA, Alvarez JA, Blasco MA, Nunez A. Non-cardiogenic pulmonary edema after oral ingestion of hydrochlorothiazide . Intensive Care Med. 1987;13:364-5.

57. Luxenberg J, Feigenbaum LZ. The use of reserpine for elderly hypertensive patients. J Am Geriatr Soc. 1983;31:556-9.

58. Gibb WE, Malpas JS, Turner P, White RJ. Comparison of bethanidine, alpha-methyldopa, and reserpine in essential hypertension. Lancet. 1970;2:275-7.

59. Segal MS. Bronchospasm after reserpine. N Engl J Med. 1969;281:1426-7.

60. Atuk NO, Owen JA, Jr. Bronchospasm after reserpine. N Engl J Med. 1969;281:908-9.

61. Diamond L. Drug-induced bronchospasm. J Clin Pharmacol J New Drugs. 1970;10:215-6.

62. Pfeifer HJ, Greenblatt DK, Koch-Wester J. Clinical toxicity of reserpine in hospitalized patients: a report from the Boston Collaborative Drug Surveillance Program. Am J Med Sci. 1976;271:269-76.

63. Bacher NM, Lewis HA. Reserpine and tardive dyskinesia. Am J Psychiatry. 1984;141:719.

64. Dilsaver SC, Greden JF. Possible cholinergic mechanism in reserpine and tardive dyskinesia. Am J Psychiatry. 1984;141:151-2.

65. Peters HA. Questioning reserpine's adverse effect on tardive dyskinesia. Am J Psychiatry. 1983;140:1106.

66. Donatelli A, Geisen L, Feuer E. Case report of adverse effect of reserpine on tardive dyskinesia. Am J Psychiatry. 1983;140:239-40.

67. Ross RT. Drug-induced parkinsonism and other movement disorders. Can J Neurol Sci. 1990;17:155-62.

68. Reus VI. Behavioral side effects of medical drugs. Prim Care. 1979;6:283-94.

69. Goodwin FK, Bunney WE, Jr. Depressions following reserpine: a reevaluation. Semin Psychiatry. 1971;3:435-48.

70. Magil AB, Ballon HS, Cameron EC, Rae A. Acute interstitial nephritis associated with thiazide diuretics. Clinical and pathologic observations in three cases. Am J Med. 1980;69:939-43.

71. Hoss DM, Nierenberg DW. Severe shaking chills and fever following hydrochlorothiazide administration. Am J Med. 1988;85:747.

72. Magil AB. Drug-induced acute interstitial nephritis with granulomas. Hum Pathol. 1983;14:36-41.

73. Goette DK, Beatrice E. Erythema annulare centrifugum caused by hydrochlorothiazide-induced interstitial nephritis. Int J Dermatol. 1988;27:129-30.

74. Freis ED. Reserpine in hypertension: present status. Am Fam Physician. 1975;11:120-2.

75. Fleishman M. Letter: Reserpine, ECT, and depression. Am J Psychiatry. 1975;132:1088.

76. Lewis WH. Iatrogenic psychotic depressive reaction in hypertensive patients. Am J Psychiatry. 1971;127:1416-7.

77. Blumenthal M, Davis R, Doe RP. Carcinoid syndrome following reserpine therapy in thyrotoxicosis. Arch Intern Med. 1965;116:819-23.

78. Kent TA, Wilber RD. Reserpine withdrawal psychosis: the possible role of denervation supersensitivity of receptors. J Nerv Ment Dis. 1982;170:502-4.

79. Samuels AH, Taylor AJ. Reserpine withdrawal psychosis. Aust N Z J Psychiatry. 1989;23:129-30.

80. Ambrosino SV. Depressive reactions associated with reserpine. N Y State J Med. 1974;74:860-4.

81. Okada F. Depression after treatment with thiazide diuretics for hypertension. Am J Psychiatry. 1985;142:1101-2.

82. Bjornberg A, Gisslen H. Thiazides: A cause of necrotising vasculitis? Lancet. 1965;2:982-3.

83. Reed BR, Huff JC, Jones SK, Orton PW, Lee LA, Norris DA. Subacute cutaneous lupus erythematosus associated with hydrochlorothiazide therapy. Ann Intern Med. 1985;103:49-51.

84. Diffey BL, Langtry J. Phototoxic potential of thiazide diuretics in normal subjects. Arch Dermatol. 1989;125:1355-8.

85. Robinson HN, Morison WL, Hood AF. Thiazide diuretic therapy and chronic photosensitivity. Arch Dermatol. 1985;121:522-4.

86. Parodi A, Romagnoli M, Rebora A. Subacute cutaneous lupus erythematosus-like eruption caused by hydrochlorothiazide. Photodermatol. 1989;6:100-2.

87. Goodrich AL, Kohn SR. Hydrochlorothiazide-induced lupus erythematosus: a new variant? J Am Acad Dermatol. 1993;28:1001-2.

88. Dillon PT, Babe J, Meloni CR, Canary JJ. Reserpine in thyrotoxic crisis. N Engl J Med. 1970;283:1020-3.

89. Dietz MW. Iatrogenic jejunal ulcer. Am J Roentgenol Radium Ther Nucl Med. 1967;99:136-8.

90. Reinus FZ, Weinberger HA, Fischer WW. Medication-induced ulceration of the small bowel. Am J Surg. 1966;112:97-101.

91. Wagner W, Longerbeam JK, Smith LL, Feikes HL. Drug-induced ulcers of the small bowel causing intestinal obstruction or perforation. Am Surg. 1967;33:7-11.

92. Campbell JR, Knapp RW. Small bowel ulceration associated with thiazide and potassium therapy: review of 13 cases. Ann Surg. 1966;163:291-6.

93. Smith BL, Tedeschi A, Lane CD. Pancreatitis with a twist. Hosp Pract (Off Ed). 1988;23:150,.

94. Holland GW. Stenosing ulcers of the small bowel associated with thiazide and potassium therapy. N Z Med J. 1965;64:383-5.

95. Delevett AF, Recalde M. Diuretic-induced renal colic. JAMA. 1973;225:992.

96. Paloyan E, Farland M, Pickleman JR. Hyperparathyroidism coexisting with hypertension and prolonged thiazide administration. JAMA. 1969;210:1243-5.

97. Balizet L. Recurrent parathyroid adenoma. Association with prolonged thiazide administration. JAMA. 1973;225:1238-9.

98. Garratty G, Houston M, Petz LD, Webb M. Acute immune intravascular hemolysis due to hydrochlorothiazide. Am J Clin Pathol. 1981;76:73-8.

99. Eisner EV, Crowell EB. Hydrochlorothiazide-dependent thrombocytopenia due to IgM antibody. JAMA. 1971;215:480-2.

100. Srivastava G, Agarwal KN. Thiazide-induced bone-marrow aplasia. Report of a case. Indian J Pediatr. 1967;34:407-9.

101. Beck ML, Cline JF, Hardman JT, Racela LS, Davis JW. Fatal intravascular immune hemolysis induced by hydrochlorothiazide. Am J Clin Pathol. 1984;81:791-4.

102. Shirey RS, Bartholomew J, Bell W, Pollack B, Kickler TS, Ness PM. Characterization of antibody and selection of alternative drug therapy in hydrochlorothiazide-induced immune hemolytic anemia. Transfusion. 1988;28:70-2.

103. Entrican JH, Denburg JA, Gauldie J, Kelton JG. Angioimmunoblastic lymphadenopathy associated with reserpine. Lancet. 1984;2:820-1.

104. Mack TM, Henderson BE, Gerkins VR, et al. Reserpine and breast cancer in a retirement community. N Engl J Med. 1975;292:1366-71.

105. Kodlin D, McCarthy N. Reserpine and breast cancer. Cancer. 1978;41:761-8.

106. Curb JD, Hardy RJ, Labarthe DR, Borhani NO, Taylor JO. Reserpine and breast cancer in the Hypertension Detection and Follow- Up Program. Hypertension. 1982;4:307-11.

107. Labarthe DR, O'Fallon WM. Reserpine and breast cancer. A community-based longitudinal study of 2,000 hypertensive women. JAMA. 1980;243:2304-10.

108. Jick H. Editorial: Reserpine and breast cancer: a perspective. JAMA. 1975;233:896-7.

109. Newball HH, Byar DP. Does reserpine increase prolactin and exacerbate cancer of prostate? Case control study. Urology. 1973;2:525-9.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.