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Ranolazine Side Effects

In Summary

More frequently reported side effects include: dizziness, constipation, and nausea. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to ranolazine: oral tablet extended release

As well as its needed effects, ranolazine may cause unwanted side effects that require medical attention.

Major Side Effects

If any of the following side effects occur while taking ranolazine, check with your doctor immediately:

More common:
  • Dizziness
Less common:
  • Bloating or swelling of the face, arms, hands, lower legs, or feet
  • continuous ringing or buzzing or other unexplained noise in the ears
  • difficult or labored breathing
  • fast, irregular, pounding, or racing heartbeat or pulse
  • feeling of constant movement of self or surroundings
  • hearing loss
  • lightheadedness
  • rapid weight gain
  • sensation of spinning
  • tightness in the chest
  • tingling of the hands or feet
  • unusual weight gain or loss
  • Abnormal or decreased touch sensation
  • agitation
  • blood in the urine
  • blurred vision
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • chest pain or discomfort
  • chills
  • cold sweats
  • coma
  • confusion
  • decreased urine output
  • depression
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • fainting
  • headache
  • hostility
  • irritability
  • lethargy
  • muscle twitching
  • nausea
  • seizures
  • shakiness in the legs, arms, hands, or feet
  • slow or irregular heartbeat
  • stupor
  • sweating
  • trembling or shaking of the hands or feet
  • unusual tiredness or weakness

Minor Side Effects

Some ranolazine side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common:
  • Difficulty having a bowel movement (stool)
Less common:
  • Dry mouth
  • stomach pain
  • Lack or loss of strength

For Healthcare Professionals

Applies to ranolazine: oral tablet extended release


The most common adverse reactions were dizziness, headache, constipation, and nausea.[Ref]


Common (1% to 10%): Constipation, nausea, vomiting
Uncommon (0.1% to 1%): Abdominal pain, dry mouth, dyspepsia, flatulence, stomach discomfort
Rare (less than 0.1%): Pancreatitis, erosive duodenitis, oral hypoesthesia[Ref]

Nervous system

Common (1% to 10%): Dizziness, headache
Uncommon (0.1% to 1%): Lethargy, syncope, hypoesthesia, somnolence, tremor, postural dizziness, paresthesia, vertigo, tinnitus
Rare (less than 0.1%): Amnesia, depressed level of consciousness, loss of consciousness, coordination abnormal, gait disturbance, parosmia[Ref]


Common (1% to 10%): Asthenia
Uncommon (0.1% to 1%): Fatigue, peripheral edema
Rare (less than 0.1%): Impaired hearing[Ref]


Uncommon (0.1% to 1%): Anorexia, appetite decreased, dehydration, weight decreased
Rare (less than 0.1%): Hyponatremia
Postmarketing reports: Hypoglycemia[Ref]


Uncommon (0.1% to 1%): Anxiety, insomnia, confusional state, hallucination
Rare (less than 0.1%): Disorientation[Ref]


Uncommon (0.1% to 1%): Pain in extremity, muscle cramp, joint swelling, muscular weakness[Ref]


Uncommon (0.1% to 1%): Hot flush, hypotension, prolonged QT corrected interval
Rare (less than 0.1%): Peripheral coldness, orthostatic hypotension
Frequency not reported: Bradycardia, palpitations[Ref]


Uncommon (0.1% to 1%): Dysuria, hematuria, chromaturia
Rare (less than 0.1%): Urinary retention, erectile dysfunction[Ref]


Uncommon (0.1% to 1%): Dyspnea, cough, epistaxis
Rare (less than 0.1%): Throat tightness
Frequency not reported: Pulmonary fibrosis[Ref]


Uncommon (0.1% to 1%): Blurred vision, visual disturbance, diplopia[Ref]


Uncommon (0.1% to 1%): Serum creatinine increased, blood urea increased
Rare (less than 0.1%): Acute renal failure
Frequency not reported: Blood urea increased[Ref]


Uncommon (0.1% to 1%): Pruritus, hyperhidrosis
Rare (less than 0.1%): Angioedema, urticaria, cold sweat, rash[Ref]


Uncommon (0.1% to 1%): Platelet or white blood cell count increased
Frequency not reported: Eosinophilia, thrombocytopenia, leukopenia, pancytopenia[Ref]


Rare (less than 0.1%): Hepatic enzyme levels elevated[Ref]


1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

2. "Product Information. Ranexa (ranolazine)." Calmoseptine Inc, Huntington Beach, CA.

It is possible that some side effects of ranolazine may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.