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Ranolazine Side Effects

Medically reviewed by Drugs.com. Last updated on Apr 20, 2023.

Applies to ranolazine: oral packet, oral tablet extended release.

Serious side effects of Ranolazine

Along with its needed effects, ranolazine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking ranolazine:

More common

Less common

Rare

Incidence not known

Other side effects of Ranolazine

Some side effects of ranolazine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Less common

Rare

For Healthcare Professionals

Applies to ranolazine: oral granule extended release, oral tablet extended release.

General

The most common adverse reactions were dizziness, headache, constipation, and nausea.[Ref]

Gastrointestinal

Common (1% to 10%): Constipation, nausea, vomiting

Uncommon (0.1% to 1%): Abdominal pain, dry mouth, dyspepsia, flatulence, stomach discomfort

Rare (less than 0.1%): Pancreatitis, erosive duodenitis, oral hypoesthesia[Ref]

Nervous system

Common (1% to 10%): Dizziness, headache

Uncommon (0.1% to 1%): Lethargy, syncope, hypoesthesia, somnolence, tremor, postural dizziness, paresthesia, vertigo, tinnitus

Rare (less than 0.1%): Amnesia, depressed level of consciousness, loss of consciousness, coordination abnormal, gait disturbance, parosmia

Postmarketing reports: Myoclonus[Ref]

Other

Common (1% to 10%): Asthenia

Uncommon (0.1% to 1%): Fatigue, peripheral edema

Rare (less than 0.1%): Impaired hearing[Ref]

Metabolic

Uncommon (0.1% to 1%): Anorexia, appetite decreased, dehydration, weight decreased

Rare (less than 0.1%): Hyponatremia

Postmarketing reports: Hypoglycemia[Ref]

Psychiatric

Uncommon (0.1% to 1%): Anxiety, insomnia, confusional state, hallucination

Rare (less than 0.1%): Disorientation[Ref]

Musculoskeletal

Uncommon (0.1% to 1%): Pain in extremity, muscle cramp, joint swelling, muscular weakness[Ref]

Cardiovascular

Uncommon (0.1% to 1%): Hot flush, hypotension, prolonged QT corrected interval

Rare (less than 0.1%): Peripheral coldness, orthostatic hypotension

Frequency not reported: Bradycardia, palpitations[Ref]

Genitourinary

Uncommon (0.1% to 1%): Dysuria, hematuria, chromaturia

Rare (less than 0.1%): Urinary retention, erectile dysfunction[Ref]

Respiratory

Uncommon (0.1% to 1%): Dyspnea, cough, epistaxis

Rare (less than 0.1%): Throat tightness

Frequency not reported: Pulmonary fibrosis[Ref]

Ocular

Uncommon (0.1% to 1%): Blurred vision, visual disturbance, diplopia[Ref]

Renal

Uncommon (0.1% to 1%): Serum creatinine increased, blood urea increased

Rare (less than 0.1%): Acute renal failure

Frequency not reported: Blood urea increased[Ref]

Dermatologic

Uncommon (0.1% to 1%): Pruritus, hyperhidrosis

Rare (less than 0.1%): Angioedema, urticaria, cold sweat, rash[Ref]

Hematologic

Uncommon (0.1% to 1%): Platelet or white blood cell count increased

Frequency not reported: Eosinophilia, thrombocytopenia, leukopenia, pancytopenia[Ref]

Hepatic

Rare (less than 0.1%): Hepatic enzyme levels elevated[Ref]

References

1. Product Information. Ranexa (ranolazine). Calmoseptine Inc. 2006.

2. Cerner Multum, Inc. UK Summary of Product Characteristics.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.