Medically reviewed by Drugs.com. Last updated on Sep 2, 2022.
Applies to the following strengths: 500 mg; 1000 mg
Usual Adult Dose for:
Additional dosage information:
Usual Adult Dose for Angina Pectoris
500 mg orally twice a day; increase to 1000 mg orally twice a day as needed
Maximum dose: 1000 mg orally twice a day
Use: Treatment of chronic angina
Renal Dose Adjustments
Dose adjustment(s) may be required; however, no specific guidelines have been suggested. Caution recommended.
If acute renal failure develops during therapy: Discontinue this drug
Liver Dose Adjustments
Liver cirrhosis: Contraindicated
Concomitant use of moderate CYP450 3A4 inhibitors: Maximum dose: 500 mg orally twice a day
Concomitant use of strong CYP450 3A4 inhibitors: Contraindicated
Concomitant use of P-gp inhibitors: Titrate based on clinical response
Safety and efficacy have not been established in patients younger than 18 years.
Consult WARNINGS section for additional precautions.
Data not available
- Do not crush, break, or chew.
- If a dose is missed, take the next dose at the next scheduled time; do not double the next dose.
- Renal: Serum creatinine and BUN after initiation and periodically thereafter in patients with moderate to severe renal impairment (CrCl less than 60 mL/min).
- Inform patients that this drug is not used for acute angina episodes.
- Advise patients to report any new use of prescription or non-prescription products, including herbal remedies and nutritional supplements, to their physician and pharmacist.
- Advise patients to limit the use of grapefruit products when taking this drug.
- Inform patients that this drug may cause dizziness and lightheadedness. Patients should know how they react to this drug before engaging in activities requiring mental alertness or coordination.
- Advise patients to contact their physician if they experience fainting spells.
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