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Procaine penicillin Side Effects

For the Consumer

Applies to procaine penicillin: intramuscular suspension

Get emergency medical help if you have any of these signs of an allergic reaction while taking procaine penicillin: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

  • diarrhea that is watery or bloody;

  • peeling skin , severe pain, or changes in skin color where the medicine was injected;

  • dizziness, joint or muscle pain;

  • fast or pounding heartbeats;

  • numbness, tingling, pain, swelling, or redness in your arms or legs;

  • confusion, agitation, depression, unusual thoughts or behavior;

  • chest pain, problems with vision or speech;

  • feeling like you might pass out;

  • fever, chills, dizziness, muscle pain, rapid breathing or heart rate;

  • uncontrolled muscle movements, problems with balance or walking;

  • pale skin, easy bruising or bleeding, unusual weakness;

  • sore throat, flu symptoms;

  • urinating less than usual or not at all;

  • rash or itching with swollen glands, joint pain, or general ill feeling; or

  • slow heart rate, weak pulse, fainting, slow breathing.

Less serious side effects of procaine penicillin may include:

  • pain where the injection was given;

  • vaginal itching or discharge;

  • white patches in your mouth or throat;

  • nausea, vomiting;

  • blurred vision, ringing in your ears;

  • headache, dizziness; or

  • mild skin rash,

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For Healthcare Professionals

Applies to procaine penicillin: intramuscular suspension


Hypersensitivity side effects associated with penicillin have included skin rashes (ranging from maculopapular eruptions to exfoliative dermatitis), urticaria, and serum sickness-like reactions (including chills, fever, edema, arthralgia, and prostration). Anaphylaxis (severe and often fatal) and Jarisch-Herxheimer reaction (as with other treatments for syphilis) have been reported. Procaine toxicity manifestations and hypersensitivity reactions have been reported.[Ref]


Gastrointestinal side effects associated with penicillin G have included pseudomembranous colitis.[Ref]

The onset of pseudomembranous colitis symptoms may occur during or after treatment.[Ref]


Psychiatric side effects have included a syndrome manifested by a variety of central nervous system symptoms such as severe agitation with confusion, visual and auditory hallucinations, and a fear of impending death (Hoigne's syndrome) following procaine penicillin use. Other symptoms associated with this syndrome have included psychosis, seizures, dizziness, tinnitus, cyanosis, palpitations, tachycardia, and abnormal taste perception.[Ref]


Renal side effects associated with parenteral penicillin G have included nephropathy.[Ref]


Hematologic side effects associated with parenteral penicillin G have included hemolytic anemia, leukopenia, and thrombocytopenia.[Ref]

Nervous system

Nervous system side effects associated with parenteral penicillin G have included neuropathy.[Ref]


1. "Product Information. Penicillin G Procaine (procaine penicillin)." Monarch Pharmaceuticals Inc, Bristol, TN.

2. "Product Information. Bicillin C-R 900/300 (benzathine penicillin-procaine penicillin)." Wyeth Laboratories, Philadelphia, PA.

Some side effects of procaine penicillin may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.