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Procaine Penicillin Dosage

Applies to the following strengths: 1,200,000 units/2 mL; 600,000 units/mL; 2,400,000 units/4 mL

Usual Adult Dose for Skin or Soft Tissue Infection

600,000 to 1,000,000 units/day IM for at least 10 days

Uses: Moderately severe to severe group A streptococcal infections (tonsillitis, erysipelas, scarlet fever, upper respiratory tract, skin and soft tissue)/moderately severe to severe infections of the upper respiratory tract, skin and soft tissue infections, scarlet fever, and erysipelas due to susceptible streptococci (group A without bacteremia)

Usual Adult Dose for Upper Respiratory Tract Infection

600,000 to 1,000,000 units/day IM for at least 10 days

Uses: Moderately severe to severe group A streptococcal infections (tonsillitis, erysipelas, scarlet fever, upper respiratory tract, skin and soft tissue)/moderately severe to severe infections of the upper respiratory tract, skin and soft tissue infections, scarlet fever, and erysipelas due to susceptible streptococci (group A without bacteremia)

Usual Adult Dose for Tonsillitis/Pharyngitis

600,000 to 1,000,000 units/day IM for at least 10 days

Uses: Moderately severe to severe group A streptococcal infections (tonsillitis, erysipelas, scarlet fever, upper respiratory tract, skin and soft tissue)/moderately severe to severe infections of the upper respiratory tract, skin and soft tissue infections, scarlet fever, and erysipelas due to susceptible streptococci (group A without bacteremia)

Usual Adult Dose for Streptococcal Infection

600,000 to 1,000,000 units/day IM for at least 10 days

Uses: Moderately severe to severe group A streptococcal infections (tonsillitis, erysipelas, scarlet fever, upper respiratory tract, skin and soft tissue)/moderately severe to severe infections of the upper respiratory tract, skin and soft tissue infections, scarlet fever, and erysipelas due to susceptible streptococci (group A without bacteremia)

Usual Adult Dose for Endocarditis

600,000 to 1,000,000 units/day IM

Uses:

Usual Adult Dose for Fusospirochetosis

600,000 to 1,000,000 units/day IM

Uses:

Usual Adult Dose for Pneumonia

600,000 to 1,000,000 units/day IM

Uses:

Usual Adult Dose for Bacterial Infection

600,000 to 1,000,000 units/day IM

Uses:

Usual Adult Dose for Cutaneous Bacillus anthracis

600,000 to 1,000,000 units/day IM

Uses:

Usual Adult Dose for Rat-bite Fever

600,000 to 1,000,000 units/day IM

Uses:

Usual Adult Dose for Anthrax Prophylaxis

1.2 million units IM every 12 hours
Total duration of therapy: 60 days

Comments:


Use: Inhalational anthrax (postexposure) to reduce incidence/progression of infection after exposure to aerosolized Bacillus anthracis

Usual Adult Dose for Neurosyphilis

600,000 units/day IM for 10 to 15 days
Total dosage: 6 to 9 million units

Use: Late syphilis (tertiary, neurosyphilis) due to susceptible Treponema pallidum

US CDC and Panel on Opportunistic Infections in Adults and Adolescents with HIV Recommendations: 2.4 million units IM once a day for 10 to 14 days

Comments:

Usual Adult Dose for Tertiary Syphilis

600,000 units/day IM for 10 to 15 days
Total dosage: 6 to 9 million units

Use: Late syphilis (tertiary, neurosyphilis) due to susceptible Treponema pallidum

US CDC and Panel on Opportunistic Infections in Adults and Adolescents with HIV Recommendations: 2.4 million units IM once a day for 10 to 14 days

Comments:

Usual Adult Dose for Syphilis - Latent

With a negative spinal fluid: 600,000 units/day IM for 8 days
Total dosage: 4,800,000 units

With positive or no spinal fluid examination: 600,000 units/day IM for 10 to 15 days
Total dosage: 6 to 9 million units

Use: Latent syphilis due to susceptible T pallidum

Usual Adult Dose for Syphilis - Early

600,000 units/day IM for 8 days
Total dosage: 4,800,000 units

Uses: Primary and secondary syphilis due to susceptible T pallidum

Usual Adult Dose for Bejel

The usual treatment is the same as for syphilis in the corresponding stage of disease.

Uses: Bejel, pinta, yaws due to susceptible organisms

Usual Adult Dose for Yaws

The usual treatment is the same as for syphilis in the corresponding stage of disease.

Uses: Bejel, pinta, yaws due to susceptible organisms

Usual Adult Dose for Pinta

The usual treatment is the same as for syphilis in the corresponding stage of disease.

Uses: Bejel, pinta, yaws due to susceptible organisms

Usual Adult Dose for Diphtheria

Adjunctive therapy with antitoxin: 300,000 to 600,000 units/day IM
Carrier state: 300,000 units/day IM for 10 days

Uses: Adjunct to antitoxin for prevention of carrier stage of diphtheria due to susceptible Corynebacterium diphtheriae; diphtheria carrier state

US CDC Recommendations: 600,000 units every 12 hours for 14 days

Comments:

Usual Pediatric Dose for Pneumonia

Less than 27 kg: 300,000 units/day IM

Uses:


American Academy of Pediatrics (AAP) Recommendations:
Neonates: 50,000 units/kg IM every 24 hours
1 month or older: 50,000 units/kg/day IM divided in 1 or 2 doses

Comments:

Usual Pediatric Dose for Skin or Soft Tissue Infection

Less than 27 kg: 300,000 units/day IM

Uses:


American Academy of Pediatrics (AAP) Recommendations:
Neonates: 50,000 units/kg IM every 24 hours
1 month or older: 50,000 units/kg/day IM divided in 1 or 2 doses

Comments:

Usual Pediatric Dose for Upper Respiratory Tract Infection

Less than 27 kg: 300,000 units/day IM

Uses:


American Academy of Pediatrics (AAP) Recommendations:
Neonates: 50,000 units/kg IM every 24 hours
1 month or older: 50,000 units/kg/day IM divided in 1 or 2 doses

Comments:

Usual Pediatric Dose for Bacterial Infection

Less than 27 kg: 300,000 units/day IM

Uses:


American Academy of Pediatrics (AAP) Recommendations:
Neonates: 50,000 units/kg IM every 24 hours
1 month or older: 50,000 units/kg/day IM divided in 1 or 2 doses

Comments:

Usual Pediatric Dose for Streptococcal Infection

Less than 27 kg: 300,000 units/day IM

Uses:


American Academy of Pediatrics (AAP) Recommendations:
Neonates: 50,000 units/kg IM every 24 hours
1 month or older: 50,000 units/kg/day IM divided in 1 or 2 doses

Comments:

Usual Pediatric Dose for Anthrax Prophylaxis

Children: 25,000 units/kg IM every 12 hours

Total duration of therapy: 60 days

Comments:

Use: Inhalational anthrax (postexposure) to reduce incidence/progression of infection after exposure to aerosolized B anthracis

Usual Pediatric Dose for Congenital Syphilis

Less than 32 kg: 50,000 units/kg/day IM for 10 days

US CDC and AAP Recommendations: 50,000 units/kg IM once a day for 10 days


Comments:

Usual Pediatric Dose for Syphilis - Early

Greater than 12 years: 600,000 units/day IM for 8 days
Total dosage: 4,800,000 units

Use: Primary, secondary, and latent with a negative spinal fluid

Usual Pediatric Dose for Syphilis - Latent

Greater than 12 years: 600,000 units/day IM for 8 days
Total dosage: 4,800,000 units

Use: Primary, secondary, and latent with a negative spinal fluid

Usual Pediatric Dose for Neurosyphilis

Panel on Opportunistic Infections in Adults and Adolescents with HIV Recommendations: 2.4 million units IM once a day for 10 to 14 days

Comments:

Usual Pediatric Dose for Diphtheria

US CDC Recommendations:


AAP Recommendations:

Duration of Therapy: 14 days

Comments:

Renal Dose Adjustments

Data not available

Comments:

Liver Dose Adjustments

Data not available

Precautions

US BOXED WARNING:


CONTRAINDICATIONS:
Previous hypersensitivity reaction to any penicillin

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:


Storage requirements:

General:

Monitoring:

Patient advice:

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.