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Plasma protein fraction Side Effects

Medically reviewed by Last updated on Jul 22, 2022.

Applies to plasma protein fraction: parenteral solution for injection.

Side effects include:

Flushing, urticaria, nausea, headache, back pain.

For Healthcare Professionals

Applies to plasma protein fraction: intravenous solution.


Very rare (less than 0.01%): Cardiac arrest, arrhythmia, tachycardia, thromboembolism, hypotension, hypertension, circulatory overload, circulatory collapse, flushing

Frequency not reported: Severe hypotension, chest pain, chest discomfort[Ref]


Common (1% to 10%): Urticaria, pruritus

Very rare (less than 0.01%): Rash (erythematous), hyperhidrosis[Ref]


Uncommon (0.1% to 1%): Nausea, vomiting

Very rare (less than 0.01%): Abdominal pain[Ref]


Very rare (less than 0.01%): Back pain[Ref]

Nervous system

Uncommon (0.1% to 1%): Hypoesthesia

Very rare (less than 0.01%): Dizziness, paresthesia

Frequency not reported: Headache[Ref]


Very rare (less than 0.01%): Hemolytic anemia, hemorrhagic diathesis, citrate toxicity

Frequency not reported: Hyperfibrinolysis[Ref]


Uncommon (0.1% to 1%): Anaphylaxis

Rare (less than 0.1%): Hypersensitivity[Ref]


Very rare (less than 0.01%): Application site reaction[Ref]


Frequency not reported: Alkalosis[Ref]


Very rare (less than 0.01%): Anxiety, agitation, restlessness[Ref]


Uncommon (0.1% to 1%): Hypoxia

Very rare (less than 0.01%): Respiratory failure, pulmonary hemorrhage, bronchospasm, pulmonary edema, dyspnea, respiratory disorder, oxygen saturation decreased

Frequency not reported: Tachypnea[Ref]


Uncommon (0.1% to 1%): Pyrexia

Very rare (less than 0.01%): Chills, localized edema, malaise, antibody test positive[Ref]

More about plasma protein fraction

Patient resources

Other brands


Professional resources

Related treatment guides


1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

2. "Product Information. Plasmanate (plasma protein fraction)." Bayer Pharmaceutical Inc (2013):

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.