Pemoline Side Effects
Applies to pemoline: oral tablet, oral tablet chewable
As of October 2005, hepatic failure resulting in liver transplant or death, usually within 4 weeks of onset of signs and symptoms of hepatic failure, has been reported in at least 13 patients receiving pemoline. The reporting rate for hepatic failure with pemoline is 10 to 25 times greater than the background rate of hepatic failure in the general population.[Ref]
General side effects have included insomnia which has been reported to be the most frequent side effect with the use of pemoline. Growth suppression has been associated with the long term use of stimulants in children.[Ref]
Nervous system side effects including seizures, hallucinations, dyskinetic movements of the tongue, lips, face, and extremities, mild depression, dizziness, increased irritability, headache, and drowsiness have been reported.[Ref]
Ocular side effects have included nystagmus and oculogyric crisis.[Ref]
Anorexia and weight loss tend to occur during the first weeks of therapy. Most cases are transient. Weight gain usually resumes within 3 to 6 months.[Ref]
The case of severe hypotension was reported in a patient receiving pemoline during general anesthesia.[Ref]
Other side effects including ototoxicity have been reported.[Ref]
Genitourinary side effects have included an isolated case of elevated serum acid phosphatase in one man with prostatic enlargement. (The serum acid phosphatase normalized upon discontinuation of pemoline and elevated again on rechallenge.)[Ref]
1. Sterling MJ, Kane M, Grace ND "Pemoline-induced autoimmune hepatitis." Am J Gastroenterol 91 (1996): 2233-4
2. "Product Information. Cylert (pemoline)." Abbott Pharmaceutical, Abbott Park, IL.
3. Berkovitch M, Pope E, Phillips J, Koren G "Pemoline-associated fulminant liver failure: testing the evidence for causation." Clin Pharmacol Ther 57 (1995): 696-8
4. Shuster J "Adverse drug reaction. Pemoline and dyskinesia." Nursing 29 (1999): 24
5. Bohringer CH, Jahr JS, Rowell S, Mayer K "Severe hypotension in a patient receiving pemoline during general anesthesia." Anesth Analg 91 (2000): 1131-3
6. "Multum Information Services, Inc. Expert Review Panel"
More about pemoline
- During Pregnancy
- Dosage Information
- Drug Images
- Drug Interactions
- 14 Reviews
- Drug class: CNS stimulants
- FDA Alerts (2)
- Other brands
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Some side effects may not be reported. You may report them to the FDA.