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Oritavancin Side Effects

For the Consumer

Applies to oritavancin: intravenous powder for solution

As well as its needed effects, oritavancin may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking oritavancin, check with your doctor or nurse immediately:

Less common:
  • Changes in skin color
  • dry, red, hot, or irritated skin
  • fast, pounding, or irregular heartbeat or pulse
  • pain, swelling, or tenderness in the skin
Less common or rare:
  • Black, tarry stools
  • blistering, peeling, or loosening of the skin
  • fever
  • hives, itching skin, or rash
  • increase in bone pain
  • joint pain, stiffness, or swelling
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • redness, soreness, or itching skin
  • sores, welting, or blisters
  • swelling of the eyelids, face, lips, hands, or feet
  • swollen glands
  • tightness in the chest
  • unusual bleeding or bruising
Incidence not known:
  • Abdominal or stomach tenderness
  • severe abdominal or stomach cramps and pain
  • watery and severe diarrhea, which may also be bloody

Minor Side Effects

Some oritavancin side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

Less common or rare:
  • Dizziness
  • headache
  • nausea or vomiting

For Healthcare Professionals

Applies to oritavancin: intravenous powder for injection


In pooled clinical trials, serious side effects were reported in 5.8% of patients treated with this drug (compared to 5.9% treated with vancomycin). Cellulitis was the serious side effect reported most often with both drugs. The most common side effects reported in patients treated with this drug were headache, nausea, vomiting, limb and subcutaneous abscesses, and diarrhea. This drug was discontinued due to side effects in 3.7% of patients; most often due to cellulitis and osteomyelitis.[Ref]


Common (1% to 10%): Nausea, vomiting, diarrhea
Frequency not reported: Clostridium difficile associated diarrhea[Ref]

Nervous system

Common (1% to 10%): Headache, dizziness[Ref]


Common (1% to 10%): Infusion site phlebitis, infusion site reaction, abscess (limb and subcutaneous)
Frequency not reported: Infusion related reactions (including pruritus, urticaria, flushing), osteomyelitis, infusion site erythema, extravasation, induration, peripheral edema[Ref]


Common (1% to 10%): Increased ALT, increased AST
Frequency not reported: Increased total bilirubin[Ref]


Common (1% to 10%): Tachycardia[Ref]


Frequency not reported: Cellulitis, pruritus, rash, urticaria, angioedema, erythema multiforme, pruritus, leukocytoclastic vasculitis[Ref]


Frequency not reported: Hypersensitivity reactions[Ref]


Frequency not reported: Anemia, eosinophilia[Ref]


Frequency not reported: Hyperuricemia, hypoglycemia[Ref]


Frequency not reported: Tenosynovitis, myalgia[Ref]


Frequency not reported: Bronchospasm, wheezing[Ref]


1. "Product Information. Orbactiv (oritavancin)." The Medicines Company, Parsippany, NJ.

It is possible that some side effects of oritavancin may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.