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Oritavancin Dosage

Medically reviewed on September 5, 2018.

Applies to the following strengths: 400 mg

Usual Adult Dose for Skin and Structure Infection

1200 mg via IV infusion (over 3 hours) once

Comment: This drug should be given as a single dose.

Use: For the treatment of acute bacterial skin and skin structure infections due to susceptible isolates of Staphylococcus aureus (including methicillin-susceptible and methicillin-resistant isolates), Streptococcus pyogenes, S agalactiae, S dysgalactiae, S anginosus group (includes S anginosus, S intermedius, and S constellatus), and Enterococcus faecalis (vancomycin-susceptible isolates only)

Renal Dose Adjustments

Mild or moderate renal dysfunction (CrCl 30 to 79 mL/min): No adjustment recommended.
Severe renal dysfunction (CrCl less than 30 mL/min): Data not available

Liver Dose Adjustments

Mild or moderate liver dysfunction (Child-Pugh A or B): No adjustment recommended.
Severe liver dysfunction (Child-Pugh C): Data not available

Precautions

CONTRAINDICATIONS:
-Hypersensitivity to the active component or any of the ingredients
-Use of IV unfractionated heparin sodium for 120 hours (5 days) after administration

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Comment: This drug is not removed by hemodialysis.

Other Comments

Administration advice:
-Administer via IV infusion over 3 hours; reconstitute and dilute prior to infusion.
-Slow the rate or interrupt infusion if infusion reaction occurs.
-If same IV line is used for sequential infusion of additional drugs, line should be flushed before and after infusion of this drug with 5% dextrose in sterile water (D5W); the manufacturer product information should be consulted.

Storage requirements:
-Vials of lyophilized powder: Should store at 20C to 25C (68F to 77F); excursions to 15C to 30C (59F to 86F) permitted
-Diluted IV solution in infusion bag: Should use within 6 hours when stored at room temperature or within 12 hours when refrigerated at 2C to 8C (36F to 46F)
-Combined storage time (reconstituted solution in vial and diluted solution in bag) and infusion time (3 hours) should not exceed 6 hours at room temperature or 12 hours if refrigerated.

Reconstitution/preparation techniques: The manufacturer product information should be consulted.

IV compatibility:
-Compatible: D5W
-Incompatible: Normal saline (including other IV substances, additives, or other drugs mixed in normal saline), drugs formulated at a basic or neutral pH

General:
-Limitations of use: Safety and efficacy in patients with bacteremia, peripheral vascular disease, neutropenia, those who are immunocompromised, over 65 years, and/or with infections caused by Streptococcus pyogenes have not been established.

Monitoring:
-Infections/Infestations: For signs/symptoms of osteomyelitis
-Hematologic: For signs of bleeding in patients on chronic warfarin (frequently)
-Hypersensitivity: For signs of hypersensitivity in patients with glycopeptide allergy (during infusion)

Patient advice:
-Patients should be advised to avoid missing doses and to complete the entire course of therapy.
-Patients should be told to immediately report any signs/symptoms of a hypersensitivity reaction.
-Patients should be instructed to report signs/symptoms of C difficile (e.g., watery/bloody stools, stomach cramps, fever), for up to 2 months after stopping treatment.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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