Oritavancin Dosage

Usual Adult Dose for Skin and Structure Infection

1200 mg IV as a single dose

Use: For the treatment of acute bacterial skin and skin structure infections due to susceptible isolates of Staphylococcus aureus (including methicillin-susceptible and methicillin-resistant isolates), Streptococcus pyogenes, S agalactiae, S dysgalactiae, S anginosus group (includes S anginosus, S intermedius, and S constellatus), and Enterococcus faecalis (vancomycin-susceptible isolates only)

Renal Dose Adjustments

Mild or moderate renal dysfunction: No adjustment recommended.
Severe renal dysfunction: Data not available

Liver Dose Adjustments

Mild or moderate liver dysfunction: No adjustment recommended.
Severe liver dysfunction: Data not available

Precautions

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Comments: This drug is not removed by hemodialysis.

Other Comments

Administration advice:
-Administer via IV infusion over 3 hours; reconstitute and dilute prior to infusion.
-Slowing the rate or interrupt infusion if infusion reaction occurs.
-If same IV line is used for sequential infusion of additional drugs, line should be flushed before and after infusion of this drug with 5% dextrose in sterile water (D5W); the manufacturer product information should be consulted.

Storage requirements:
-Vials of lyophilized powder: Should store at 20C to 25C (68F to 77F); excursions to 15C to 30C (59F to 86F) permitted
-Diluted IV solution in infusion bag: Should use within 6 hours when stored at room temperature or within 12 hours when refrigerated at 2C to 8C (36F to 46F)
-Combined storage time (reconstituted solution in vial and diluted solution in bag) and infusion time (3 hours) should not exceed 6 hours at room temperature or 12 hours if refrigerated.

Reconstitution/preparation techniques: The manufacturer product information should be consulted.

IV compatibility:
-Compatible: D5W
-Incompatible: Normal saline (including other IV substances, additives, or other drugs mixed in normal saline), drugs formulated at a basic or neutral pH

Monitoring:
-Infections/Infestations: For signs/symptoms of osteomyelitis
-Hematologic: For signs of bleeding in patients on chronic warfarin (frequently)
-Hypersensitivity: For signs of hypersensitivity in patients with glycopeptide allergy (during infusion)