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Generic Name: oritavancin (or IT a VAN sin)
Brand Name: Orbactiv

What is oritavancin?

Oritavancin is an antibiotic that fights bacteria.

Oritavancin is used to treat severe skin infections caused by bacteria.

Oritavancin may also be used for purposes not listed in this medication guide.

What is the most important information I should know about oritavancin?

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

What should I discuss with my healthcare provider before receiving oritavancin?

You should not receive oritavancin if you are allergic to it, or if you will be using "unfractionated" heparin within 120 hours (5 days) after your receive oritavancin injection.

To make sure oritavancin is safe for you, tell your doctor:

  • if you have ever had an allergic reaction to similar medicines such as dalbavancin, telavancin, or vancomycin;

  • if you take a blood thinner such as warfarin (Coumadin, Jantoven); or

  • if you use heparin.

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

It is not known whether oritavancin passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

How is oritavancin given?

Oritavancin is injected into a vein through an IV, and is usually given only one time in a single dose. A healthcare provider will give you this injection.

Oritavancin must be given slowly, and the IV infusion can take at least 3 hours to complete.

This medicine can cause unusual results with certain medical tests for up to 120 hours (5 days) after your injection. Tell any doctor who treats you that you have been treated with oritavancin.

Call your doctor promptly if your symptoms do not improve after receiving oritavancin.

What happens if I miss a dose?

Since oritavancin is given in a single dose, it does not have a daily dosing schedule.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while receiving oritavancin?

For at least 120 hours (5 days) after receiving oritavancin, avoid using heparin.

Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, stop using oritavancin and call your doctor. Do not use anti-diarrhea medicine unless your doctor tells you to.

Oritavancin side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Some side effects may occur during the injection. Tell your caregiver right away if you feel itchy, dizzy, nauseated, light-headed, sweaty, or have a skin rash.

Call your doctor at once if you have:

  • severe stomach pain, diarrhea that is watery or bloody;

  • fever, chills, nausea, general ill feeling; or

  • pain, tenderness, redness, swelling, or warmth anywhere in your body.

Common side effects may include:

  • nausea, vomiting, diarrhea;

  • headache; or

  • skin infections.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

Oritavancin dosing information

Usual Adult Dose for Skin and Structure Infection:

1200 mg IV as a single dose

Use: For the treatment of acute bacterial skin and skin structure infections due to susceptible isolates of Staphylococcus aureus (including methicillin-susceptible and methicillin-resistant isolates), Streptococcus pyogenes, S agalactiae, S dysgalactiae, S anginosus group (includes S anginosus, S intermedius, and S constellatus), and Enterococcus faecalis (vancomycin-susceptible isolates only)

What other drugs will affect oritavancin?

Other drugs may interact with oritavancin, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

Where can I get more information?

  • Your pharmacist can provide more information about oritavancin.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
  • Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2012 Cerner Multum, Inc. Version: 1.02.

Date modified: October 14, 2016
Last reviewed: February 12, 2016