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Oritavancin

Generic Name: oritavancin (or IT a VAN sin)
Brand Name: Orbactiv

Medically reviewed on Sep 5, 2018

What is oritavancin?

Oritavancin is an antibiotic that fights bacteria.

Oritavancin is used to treat severe skin infections caused by bacteria.

Oritavancin may also be used for purposes not listed in this medication guide.

Important Information

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

Before taking this medicine

You should not receive oritavancin if you are allergic to it, or if you will be using "unfractionated" heparin within 120 hours (5 days) after your receive oritavancin injection.

Tell your doctor if you have ever had an allergic reaction to similar medicines such as dalbavancin, telavancin, or vancomycin.

It is not known whether oritavancin will harm an unborn baby. Tell your doctor if you are pregnant.

It may not be safe to breast-feed while using this medicine. Ask your doctor about any risk.

How is oritavancin given?

Oritavancin is given as an infusion into a vein, and is usually given only one time in a single dose. A healthcare provider will give you this injection.

This medicine must be given slowly, and the infusion can take at least 3 hours to complete.

Call your doctor promptly if your symptoms do not improve after receiving oritavancin.

Oritavancin can affect the results of certain medical tests for up to 120 hours (5 days) after your injection. Tell any doctor who treats you that you have been treated with oritavancin.

What happens if I miss a dose?

Since oritavancin is given in a single dose, it does not have a daily dosing schedule.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid after receiving oritavancin?

For at least 120 hours (5 days) after receiving oritavancin, avoid using heparin.

Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, call your doctor before using anti-diarrhea medicine.

Oritavancin side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Some side effects may occur during the injection. Tell your caregiver right away if you feel warm, itchy, dizzy, light-headed, sweaty, or have a rash, or redness in your face.

Call your doctor at once if you have:

  • severe stomach pain, diarrhea that is watery or bloody;

  • fever, chills, general ill feeling; or

  • pain, tenderness, redness, swelling, or warmth anywhere in your body.

Common side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Oritavancin dosing information

Usual Adult Dose for Skin and Structure Infection:

1200 mg via IV infusion (over 3 hours) once

Comment: This drug should be given as a single dose.

Use: For the treatment of acute bacterial skin and skin structure infections due to susceptible isolates of Staphylococcus aureus (including methicillin-susceptible and methicillin-resistant isolates), Streptococcus pyogenes, S agalactiae, S dysgalactiae, S anginosus group (includes S anginosus, S intermedius, and S constellatus), and Enterococcus faecalis (vancomycin-susceptible isolates only)

What other drugs will affect oritavancin?

Tell your doctor about all your other medicines, especially:

This list is not complete. Other drugs may affect oritavancin, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Further information

  • Your doctor can provide more information about oritavancin.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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