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Orgovyx Side Effects

Generic name: relugolix

Medically reviewed by Last updated on Nov 6, 2023.

Note: This document contains side effect information about relugolix. Some dosage forms listed on this page may not apply to the brand name Orgovyx.

Applies to relugolix: oral tablet.

Serious side effects of Orgovyx

Along with its needed effects, relugolix (the active ingredient contained in Orgovyx) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking relugolix:

Less common


Incidence not known

Other side effects of Orgovyx

Some side effects of relugolix may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Less common

For Healthcare Professionals

Applies to relugolix: oral tablet.


Very common (10% or more): Decreased hemoglobin (28%)

Uncommon (0.1% to 1%): hemorrhage (0.3%)[Ref]


Very common (10% or more): Musculoskeletal pain (30%)

Uncommon (0.1% to 1%): Fracture (0.3%)[Ref]


Very common (10% or more): Increased glucose (44%), increased triglycerides (35%)

Common (1% to 10%): Increased weight[Ref]


Common (1% to 10%): Insomnia, depression, decreased libido[Ref]


Uncommon (0.1% to 1%): Urinary tract infection (0.5%)[Ref]


Very common (10% or more): Increased alanine aminotransferase (27%), increased aspartate aminotransferase (18%)[Ref]


Uncommon (0.1% to 1%): Metastatic lung cancer (0.3%)[Ref]


Uncommon (0.1% to 1%): Pneumonia (0.3%)[Ref]


Very common (10% or more): Fatigue (26%)[Ref]


Uncommon (0.1% to 1%): Acute kidney injury up to 0.6%), urinary tract infection (0.5%)[Ref]


Uncommon (0.1% to 1%): Myocardial infarction (up to 0.8%), arrhythmia (0.6%), atrioventricular block (0.3%), cardiac failure (0.3%)

Frequency not reported: Fatal and non-fatal myocardial infarction, stroke[Ref]


Common (1% to 10%): Hyperhidrosis[Ref]


Very common (10% or more): Hot flash (54%)

Common (1% to 10%): Gynecomastia[Ref]


Very common (10% or more): Constipation (12%), diarrhea (12%)

Uncommon (0.1% to 1%): Abdominal pain (0.3%)[Ref]


1. Product Information. Orgovyx (relugolix). Myovant Sciences, Inc. 2021.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.