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Nisoldipine Side Effects

For the Consumer

Applies to nisoldipine: oral tablet extended release

Along with its needed effects, nisoldipine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking nisoldipine:

More common
  • Bloating or swelling of face, arms, hands, lower legs, or feet
  • rapid weight gain
  • tingling of hands or feet
  • unusual weight gain or loss
Less common
  • Chest pain
  • dizziness, lightheadedness, or fainting
  • fast, irregular, pounding, or racing heartbeat or pulse
  • feeling of warmth or heat
  • flushing or redness of skin, especially on face and neck
  • headache
  • rash
  • sweating
Rare
  • Chest tightness
  • shortness of breath
  • swelling of the arms, face, legs, lips, tongue, or throat

Some side effects of nisoldipine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common
  • Body aches or pain
  • congestion
  • cough
  • dryness or soreness of throat
  • fever
  • heartbeat sensations
  • hoarseness
  • pain or tenderness around eyes and cheekbones
  • runny nose
  • stuffy nose
  • tender, swollen glands in neck
  • trouble in swallowing
  • voice changes

For Healthcare Professionals

Applies to nisoldipine: oral tablet extended release

General

The most commonly reported side effects included peripheral edema, headache, dizziness, and pharyngitis.[Ref]

Cardiovascular

Peripheral edema occurred as a dose-related event, with the highest frequency (27%) reported in patients receiving doses of 34 mg/day.

Peripheral edema and vasodilation were more commonly reported in white patients.[Ref]

Very common (10% or more): Peripheral edema (up to 22%)
Common (1% to 10%): Chest pain, palpitation, vasodilation
Frequency not reported: Angina, atrial fibrillation, congestive heart failure, first degree atrioventricular (AV) block, hypertension, hypotension, jugular venous distension, myocardial infarction, postural hypotension, supraventricular tachycardia, systolic ejection murmur, T wave abnormalities on ECG, T wave flattening, T wave inversion, T wave nonspecific changes, venous insufficiency, ventricular extrasystoles
Postmarketing reports: Chest tightness, tachycardia[Ref]

Nervous system

Very common (10% or more): Headache (up to 22%)
Common (1% to 10%): Dizziness
Frequency not reported: Amnesia, ataxia, cerebral ischemia, cerebrovascular accident, hypertonia, hypoesthesia, migraine, paresthesia, somnolence, syncope, taste disturbance, tremor, vertigo[Ref]

Headache was more commonly reported in elderly patients.[Ref]

Respiratory

Common (1% to 10%): Pharyngitis, sinusitis
Frequency not reported: Asthma, dyspnea, end inspiratory wheeze, epistaxis, fine rales, increased cough, laryngitis, pharyngitis, pleural effusion, rhinitis, sinusitis
Postmarketing reports: Shortness of breath[Ref]

Dermatologic

Common (1% to 10%): Rash
Frequency not reported: Acne, alopecia, cellulitis, dry skin, ecchymosis, exfoliative dermatitis, facial edema, fungal dermatitis, herpes simplex, herpes zoster, maculopapular rash, petechia, pruritus, pustular rash, skin discoloration, skin ulcer, sweating, urticaria
Postmarketing reports: Photosensitivity[Ref]

Gastrointestinal

Common (1% to 10%): Nausea
Frequency not reported: Colitis, diarrhea, dry mouth, dyspepsia, dysphagia, flatulence, gastritis, gastrointestinal hemorrhage, gingival hyperplasia, glossitis, melena, mouth ulceration[Ref]

Ocular

Frequency not reported: Abnormal vision, amblyopia, blepharitis, conjunctivitis, glaucoma, itchy eyes, keratoconjunctivitis, retinal detachment, temporary unilateral vision loss, vitreous floater, watery eyes[Ref]

Metabolic

Frequency not reported: Anorexia, diabetes mellitus, gout, hypokalemia, increased appetite, increased nonprotein nitrogen, increased serum creatine kinase, weight gain, weight loss[Ref]

Psychiatric

Frequency not reported: Abnormal dreams, abnormal thinking, anxiety, confusion, decreased libido, depression, insomnia, nervousness[Ref]

Musculoskeletal

Frequency not reported: Arthralgia, arthritis, leg cramps, myalgia, myasthenia, myositis, tenosynovitis[Ref]

Genitourinary

Frequency not reported: Dysuria, hematuria, impotence, nocturia, urinary frequency, vaginal hemorrhage, vaginitis[Ref]

Other

Frequency not reported: Chills, ear pain, fever, flu syndrome, malaise, otitis media, tinnitus[Ref]

Hepatic

Frequency not reported: Abnormal liver function tests, hepatomegaly[Ref]

Renal

Frequency not reported: Increased blood urea nitrogen, increased serum creatinine[Ref]

Hematologic

Frequency not reported: Anemia, leukopenia[Ref]

Endocrine

Frequency not reported: Thyroiditis
Postmarketing reports: Gynecomastia[Ref]

Hypersensitivity

Postmarketing reports: Angioedema, systemic hypersensitivity reaction[Ref]

References

1. "Product Information. Sular (nisoldipine)." Zeneca Pharmaceuticals, Wilmington, DE.

Some side effects of nisoldipine may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

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