Nisoldipine Dosage
Medically reviewed by Drugs.com. Last updated on Mar 5, 2025.
Applies to the following strengths: 10 mg; 20 mg; 30 mg; 40 mg; 8.5 mg; 17 mg; 25.5 mg; 34 mg
Usual Adult Dose for:
Usual Geriatric Dose for:
Additional dosage information:
Usual Adult Dose for Hypertension
Slow release (old formulation):
- Initial dose: 20 mg orally once a day
- Maintenance dose: 10 to 60 mg orally once a day
- Maximum dose: 60 mg/day
Controlled release (new formulation):
- Initial dose: 17 mg orally once a day
- Maintenance dose: 8.5 to 34 mg orally once a day
- Maximum dose: 34 mg/day
Comment: This drug has been used with diuretics, ACE inhibitors, and beta blockers.
Use: Alone or in combination with other antihypertensive agents for the treatment of hypertension
Usual Geriatric Dose for Hypertension
Slow release (old formulation):
- Initial dose: 10 mg orally once a day
- Maintenance dose: 10 to 60 mg orally once a day
- Maximum dose: 60 mg/day
Controlled release (new formulation):
- Initial dose: 8.5 mg orally once a day
- Maintenance dose: 8.5 to 34 mg orally once a day
- Maximum dose: 34 mg/day
Comments:
- Dosing should be performed with caution.
- This drug has been used with diuretics, ACE inhibitors, and beta blockers.
- Blood pressure should be closely monitored during dose adjustments.
Use: Alone or in combination with other antihypertensive agents for the treatment of hypertension
Renal Dose Adjustments
Mild to moderate renal dysfunction: No adjustment recommended.
Severe renal dysfunction: Data not available
Liver Dose Adjustments
Patients with liver dysfunction:
Slow release (old formulation):
- Initial dose: 10 mg orally once a day
- Maintenance dose: 10 to 60 mg orally once a day
- Maximum dose: 60 mg/day
Controlled release (new formulation):
- Initial dose: 8.5 mg orally once a day
- Maintenance dose: 8.5 to 34 mg orally once a day
- Maximum dose: 34 mg/day
Comments:
- This drug has been used with diuretics, ACE inhibitors, and beta blockers.
- Blood pressure should be closely monitored during dose adjustments.
Use: Alone or in combination with other antihypertensive agents for the treatment of hypertension
Severe liver dysfunction: Use with caution.
Patients with cirrhosis: Lower initial and maintenance doses should be used.
Precautions
Safety and efficacy have not been established in patients younger than 18 years.
Consult WARNINGS section for additional precautions.
Dialysis
Data not available
Other Comments
Administration advice:
- Patients should swallow the tablets whole once a day; crushing, dividing, or biting the tablets should be avoided.
- This drug should be taken 1 hour before or 2 hours after a meal.
- Grapefruit products should be avoided before and after dosing.
Storage requirements:
- Protect from light and moisture.
General:
- Slow release (old formulation) blood pressure response increases over the 10 to 60 mg daily dose range but, adverse event rates also increase.
- Controlled release (new formulation) blood pressure response increases over the 8.5 to 34 mg daily dose range, but adverse event rates also increase.
Monitoring:
- Cardiovascular: Blood pressure, heart rate, and signs/symptoms of angina, especially during initiation and titration
Patient advice:
- Patients should be told to swallow the tablets whole; chewing, crushing, or splitting tablets should be avoided.
- Patients should be instructed to take this drug 1 hour before or 2 hours after food. Grapefruit juice should be avoided during treatment.
- Advise patients to speak to their healthcare provider if they become pregnant, intend to become pregnant, or are breastfeeding.
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.