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Nesina Side Effects

Generic name: alogliptin

Medically reviewed by Drugs.com. Last updated on Jun 11, 2024.

Note: This document provides detailed information about Nesina Side Effects associated with alogliptin. Some dosage forms listed on this page may not apply specifically to the brand name Nesina.

Applies to alogliptin: oral tablet.

Serious side effects of Nesina

Along with its needed effects, alogliptin (the active ingredient contained in Nesina) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking alogliptin:

More common side effects

  • anxiety
  • blurred vision
  • chills
  • cold sweats
  • coma
  • confusion
  • cool, pale skin
  • depression
  • dizziness
  • fast heartbeat
  • headache
  • increased hunger
  • nausea
  • nightmares
  • seizures
  • shakiness
  • slurred speech
  • unusual tiredness or weakness

Less common side effects

  • chest pain or tightness
  • decreased urine output
  • dilated neck veins
  • irregular heartbeat
  • swelling of the face, fingers, feet, or lower legs
  • trouble breathing
  • weight gain

Rare side effects

  • blistering, peeling, or loosening of the skin
  • bloating
  • constipation
  • cough
  • dark-colored urine
  • diarrhea
  • difficulty with swallowing
  • feeling of discomfort
  • fever
  • general feeling of tiredness or weakness
  • headache
  • hives, itching, or rash
  • indigestion
  • inflammation of the joints
  • joint or muscle pain
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • light-colored stools
  • loss of appetite
  • muscle aches
  • pains in the stomach, side, or abdomen, possibly radiating to the back
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • red skin lesions, often with a purple center
  • red, irritated eyes
  • sore throat
  • sores, ulcers, or white spots in the mouth or on the lips
  • stomach pain, continuing
  • swollen lymph glands
  • vomiting
  • yellow eyes or skin

Incidence not known

  • redness of the skin
  • severe joint pain
  • swelling of the body

Other side effects of Nesina

Some side effects of alogliptin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common side effects

  • body aches or pain
  • ear congestion
  • loss of voice
  • sneezing
  • stuffy or runny nose

Managing side effects (general information)

For healthcare professionals

Applies to alogliptin: oral tablet.

General adverse events

The most frequently reported side effects included nasopharyngitis, headache, and upper respiratory tract infection.[Ref]

Gastrointestinal

During clinical trials, acute pancreatitis was reported in 6 (0.2%) patients receiving 25 mg and 2 patients (less than 0.1%) who were treated with active comparators or placebo. In a cardiovascular outcome trial of patient with high cardiovascular risk, acute pancreatitis was reported in 10 patients receiving this drug and 7 patients receiving placebo (0.4% vs 0.3%).[Ref]

Musculoskeletal

Between October 2006 and December 2013, thirty-three cases of severe arthralgia have been reported to the FDA Adverse Event Reporting System Database. Each case involved the use of 1 or more dipeptidyl peptidase-4 (DPP-4) inhibitor. In all cases, substantial reduction in prior activity level was reported, 10 patients were hospitalized due to disabling joint pain. In 22 cases, symptoms appeared within 1 month of starting therapy, in 23 cases symptoms resolved less than 1 month after discontinuation. A positive rechallenge was reported in 8 cases, with 6 cases involving use of a different DPP-4 inhibitor. Sitagliptin had the greatest number of cases reported (n=28) followed by saxagliptin (n=5), linagliptin (n=2), alogliptin (n=1), and vildagliptin (n=2).[Ref]

Hepatic

Hypersensitivity

Nervous system

Respiratory

Dermatologic

Dipeptidyl peptidase-4 inhibitors:

Postmarketing reports of bullous pemphigoid requiring hospitalization have been reported with dipeptidyl peptidase-4 (DPP-4) inhibitors use. These case typically recovered with topical or systemic immunosuppressive treatment and discontinuation of DPP-4 inhibitor.[Ref]

Metabolic

Based on a pooled analysis the hypoglycemic risk of this drug was considered neutral.

Cardiovascular

In a clinical trial in patients with recent acute coronary syndrome, a greater proportion of patients receiving this drug were hospitalized for congestive heart failure compared with placebo (3.9% [n=106] vs 3.3% [n=89]),[Ref]

References

1. Cerner Multum, Inc. "Australian Product Information."

2. Cerner Multum, Inc. "UK Summary of Product Characteristics."

3. (2013) "Product Information. Nesina (alogliptin)." Takeda Pharmaceuticals America

4. US Food and Drug Administration (2015) FDA Drug Safety Communication: FDA warns that DPP-4 inhibitors for type 2 diabetes may cause severe joint pain. http://www.fda.gov/downloads/Drugs/DrugSafety/UCM460038.pdf

Further information

Nesina side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer