Generic Name: linagliptin (LIN a GLIP tin)
Brand Name: Tradjenta
What is linagliptin?
Linagliptin is an oral diabetes medicine that helps control blood sugar levels. It works by regulating the levels of insulin your body produces after eating.
Linagliptin may also be used for purposes not listed in this medication guide.
You should not use this medicine if you have diabetic ketoacidosis (call your doctor for treatment).
Before taking this medicine
You should not use linagliptin if:
you have ever had a severe allergic reaction to linagliptin (breathing problems, swelling, severe skin rash); or
you have diabetic ketoacidosis (call your doctor for treatment).
To make sure linagliptin is safe for you, tell your doctor if you have ever had:
high triglycerides (a type of fat in the blood);
if you are using insulin, or taking other oral diabetes medication.
Follow your doctor's instructions about using this medicine if you are pregnant or breast-feeding a baby. Blood sugar control is very important during pregnancy, and your dose needs may be different during each trimester of pregnancy. Your dose needs may also be different while you are breast-feeding.
It is not known whether linagliptin passes into breast milk or if it could affect the nursing baby. Tell your doctor if you are breast-feeding.
This medicine is not approved for use by anyone younger than 18 years old.
How should I take linagliptin?
Follow all directions on your prescription label. Your doctor may occasionally change your dose. Do not take this medicine in larger or smaller amounts or for longer than recommended.
You may take this medicine with or without food. Follow your doctor's instructions.
Low blood sugar (hypoglycemia) can happen to everyone who has diabetes. Symptoms include headache, hunger, sweating, irritability, dizziness, nausea, fast heart rate, and feeling anxious or shaky. To quickly treat low blood sugar, always keep a fast-acting source of sugar with you such as fruit juice, hard candy, crackers, raisins, or non-diet soda.
Your doctor can prescribe a glucagon emergency injection kit to use in case you have severe hypoglycemia and cannot eat or drink. Be sure your family and close friends know how to give you this injection in an emergency.
Linagliptin is only part of a treatment program that may also include diet, exercise, weight control, blood sugar testing, and special medical care. Follow your doctor's instructions very closely.
Store at room temperature away from moisture and heat.
What happens if I miss a dose?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid while taking linagliptin?
Follow your doctor's instructions about any restrictions on food, beverages, or activity.
Linagliptin side effects
Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop taking linagliptin and call your doctor right away if you have symptoms of pancreatitis: severe pain in your upper stomach spreading to your back, nausea and vomiting, loss of appetite, or fast heartbeats.
Call your doctor at once if you have:
a severe autoimmune reaction--itching, blisters, breakdown of the outer layer of skin;
severe or ongoing pain in your joints; or
severe skin reaction--fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.
Common side effects may include:
runny or stuffy nose, sore throat;
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
Linagliptin dosing information
Usual Adult Dose for Diabetes Type 2:
Recommended dose: 5 mg orally once a day
Comments: When used in combination with insulin or an insulin secretagogue, a lower dose of the insulin secretagogue or insulin may be necessary to reduce the risk of hypoglycemia.
Use: As an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus
What other drugs will affect linagliptin?
Other drugs may increase or decrease the effects of linagliptin on lowering your blood sugar. Tell your doctor about all your current medicines and any you start or stop using, especially:
This list is not complete. Other drugs may interact with linagliptin, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.
More about linagliptin
- Side Effects
- During Pregnancy or Breastfeeding
- Dosage Information
- Drug Interactions
- Support Group
- En Español
- 34 Reviews – Add your own review/rating
- Drug class: dipeptidyl peptidase 4 inhibitors
Other brands: Tradjenta
Related treatment guides
Where can I get more information?
- Your pharmacist can provide more information about linagliptin.
- Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
- Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Copyright 1996-2012 Cerner Multum, Inc. Version: 6.01.
Date modified: March 06, 2018
Last reviewed: August 16, 2017