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Neoclarityn Side Effects

Generic Name: desloratadine

Note: This page contains side effects data for the generic drug desloratadine. It is possible that some of the dosage forms included below may not apply to the brand name Neoclarityn.

For the Consumer

Applies to desloratadine: oral syrup, oral tablet, oral tablet disintegrating

As well as its needed effects, desloratadine (the active ingredient contained in Neoclarityn) may cause unwanted side effects that require medical attention.

Major Side Effects

If any of the following side effects occur while taking desloratadine, check with your doctor immediately:

  • Anaphylaxis, such as, cough, difficulty swallowing, dizziness, fast heartbeat, hives, itching, puffiness or swelling of eyelids or around the eyes or face or lips or tongue, shortness of breath, skin rash, tightness in chest, unusual tiredness or weakness, wheezing
  • dyspnea, such as, shortness of breath, difficult or labored breathing, tightness in chest, wheezing
  • edema, such as, swelling
  • pruritus, such as, itching skin
  • rash
  • tachycardia, such as, fast, pounding, or irregular heartbeat or pulse
  • urticaria, such as, hives or welts, itching, redness of skin, skin rash.

Minor Side Effects

Some desloratadine side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common:
  • Headache
Less common:
  • Dizziness
  • dry mouth
  • dysmenorrhea, such as, difficult or painful menstruation
  • dyspepsia, such as, acid or sour stomach, belching, heartburn, indigestion, stomach discomfort , upset or pain,
  • fatigue, such as, unusual tiredness or weakness
  • myalgia, such as, joint pain, swollen joints, muscle aching or cramping, muscle pains or stiffness, difficulty in moving
  • pharyngitis, such as, body aches or pain, congestion, cough, dryness or soreness of throat, fever, hoarseness, runny nose, tender swollen glands in neck, trouble in swallowing, voice changes.
  • somnolence, such as, sleepiness or unusual drowsiness
  • nausea

For Healthcare Professionals

Applies to desloratadine: oral solution, oral tablet, oral tablet disintegrating


Cardiovascular side effects of spontaneous nature reported during the marketing of desloratadine (the active ingredient contained in Neoclarityn) have included tachycardia and palpitations.[Ref]


Hypersensitivity side effects of spontaneous nature reported during the marketing of desloratadine (the active ingredient contained in Neoclarityn) have included rash, pruritus, urticaria, edema, dyspnea, and anaphylaxis.[Ref]


Hepatic side effects have included elevated liver enzymes and bilirubin. Very rarely, hepatitis has been observed in clinical practice.[Ref]


Gastrointestinal side effects have included dry mouth, dry throat, nausea, and pharyngitis.[Ref]

Nervous system

Nervous system side effects have included somnolence and dizziness. Psychomotor hyperactivity and seizures have been observed in clinical practice.[Ref]

An increase in the incidence of somnolence has been reported in clinical trials (n=1838) at doses of 10 mg/day and 20 mg/day (5.2% and 7.6%, respectively), compared to placebo (2.3%).[Ref]


General side effects have included myalgia and influenza-like symptoms.[Ref]


1. "Product Information. Clarinex (desloratadine)." Schering Corporation, Kenilworth, NJ.

2. Layton D, Wilton L, Boshier A, Cornelius V, Harris S, Shakir SA "Comparison of the risk of drowsiness and sedation between levocetirizine and desloratadine: a prescription-event monitoring study in England." Drug Saf 29 (2006): 897-909

It is possible that some side effects of Neoclarityn may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.