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Nedocromil Side Effects

Medically reviewed by Drugs.com. Last updated on May 14, 2024.

Applies to nedocromil: inhalation aerosol with adapter.

Important warnings This medicine can cause some serious health issues

Nedocromil inhalation will not stop an asthma attack that has already started.

It is used to prevent attacks.

Do not use more of this medication than is prescribed for you.

Too much may cause serious side effects.

Use nedocromil inhalation on a regular basis for best results.

It may be one week or longer before you obtain the maximum benefit of this medication.

It is very important that you use your nedocromil inhaler properly, so that the medicine gets into your lungs.

Your doctor may want you to use a spacer with your inhaler.

Talk to your doctor about proper inhaler use.

Seek medical attention if you notice that you require more than your usual or more than the maximum amount of an asthma medication in a 24-hour period.

An increased need for medication could be an early sign of a serious asthma attack.

Serious side effects from nedocromil inhalation are not likely to occur. Seek emergency medical attention if you experience an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives).

Other, less serious side effects may be more likely to occur. Continue to use nedocromil inhalation and talk to your doctor if you experience

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

Managing side effects (general information)

For healthcare professionals

Applies to nedocromil: inhalation aerosol with adapter.

Gastrointestinal adverse events

Gastrointestinal side effects have included unpleasant taste which was reported in approximately 13% of patients receiving nedocromil and resulted in drug withdrawal in up to 3%. Less commonly, nedocromil has caused nausea and vomiting (2% to 4%).[Ref]

Respiratory

Respiratory side effects have included cough and throat irritation in 6% to 7% of patients treated with nedocromil. Bronchospasm has been induced in 5% of patients.[Ref]

Throat irritation may be relieved by drinking water before and after inhalation of nedocromil. Use of a beta-2 agonist prior to nedocromil inhalation may relieve cough and bronchospasm.[Ref]

Nervous system

Nervous system side effects have included headache in up to 6% of patients treated. Less commonly dizziness has been reported.[Ref]

Hepatic

Hepatic side effects have included elevations of liver function tests (SGPT) in approximately 3% of patients treated with nedocromil.[Ref]

References

1. Dejong JW, Teengs JP, Postma DS, Vandermark TW, Koeter GH, Demonchy JGR (1994) "Nedocromil sodium versus albuterol in the management of allergic asthma." Am J Respir Crit Care Med, 149, p. 91-7

2. Rebuck AS, Kesten S, Boulet LP, Cartier A, Cockcroft D, Gruber J, Laberge F, Lee-Chuy E, Keshmiri M, MacDonald GF, et al. (1990) "A 3-month evaluation of the efficacy of nedocromil sodium in asthma: a randomized, double-blind, placebo-controlled trial of nedocromil sodium conducted by a Canadian multicenter study group." J Allergy Clin Immunol, 85, p. 612-7

3. Foulds RA (1993) "An overview of human safety data with nedocromil sodium." J Allergy Clin Immunol, 92, p. 202-4

4. Parish RC, Miller LJ (1993) "Nedocromil sodium." Ann Pharmacother, 27, p. 599-606

5. Gonzalez JP, Brogden RN (1987) "Nedocromil sodium. A preliminary review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in the treatment of reversible obstructive airways disease." Drugs, 34, p. 560-77

6. Brogden RN, Sorkin EM (1993) "Nedocromil sodium. An updated review of its pharmacological properties and therapeutic efficacy in asthma." Drugs, 45, p. 693-715

7. (2001) "Product Information. Tilade (nedocromil)." Rhone Poulenc Rorer

Further information

Nedocromil side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

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