Skip to main content

Nebivolol Side Effects

Medically reviewed by Last updated on Jan 18, 2024.

Applies to nebivolol: oral tablet.

Serious side effects of Nebivolol

Along with its needed effects, nebivolol may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking nebivolol:

Less common

Get emergency help immediately if any of the following symptoms of overdose occur while taking nebivolol:

Symptoms of overdose

Other side effects of Nebivolol

Some side effects of nebivolol may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Less common

For Healthcare Professionals

Applies to nebivolol: oral tablet.


The more frequently reported side effects in patients treated for hypertension were headache, dizziness, and fatigue; additionally, bradycardia was frequently reported in patients treated for chronic heart failure.[Ref]


Very common (10% or more): Bradycardia (up to 11%)

Common (1% to 10%): Cardiac failure aggravation, edema, postural hypotension, first degree atrioventricular (AV) block, atrial fibrillation, hypertension, angina pectoris, chest pain

Uncommon (0.1% to 1%): Heart failure, slowed AV conduction, AV block (both second and third degree), hypotension, increased intermittent claudication, edema of the lower limbs,

Postmarketing reports: Raynaud's phenomenon, myocardial infarction, peripheral ischemia[Ref]

Bradycardia was a dose-related effect in hypertensive patients. Bradycardia occurred more frequently in chronic heart failure patients (11%) than hypertensive patients (1%) at doses of 20 to 40 mg.

Aggravation of cardiac failure occurred in 19% of patients with chronic heart failure compared to 21.3% of placebo-treated patients in the SENIORS (Study on the Effects of Nebivolol Interventions on Outcomes and Rehospitalizations in Seniors with heart failure; n = 2128; median age = 75.2 years). Heart failure occurred in 0.1% to 1% of hypertensive patients.[Ref]

Nervous system

Very common (10% or more): Dizziness (up to 11%)

Common (1% to 10%): Headache, paresthesia, somnolence, hypoesthesia

Uncommon (0.1% to 1%): Vertigo

Very rare (less than 0.01%): Syncope[Ref]


Common (1% to 10%): Dyspnea, exacerbated dyspnea, common cold, coughing, bronchitis, pharyngitis

Uncommon (0.1% to 1%): Bronchospasm

Postmarketing reports: Acute pulmonary edema[Ref]


Common (1% to 10%): Increased sweating

Uncommon (0.1% to 1%): Pruritus, erythematous rash

Very rare (less than 0.01%): Psoriasis aggravated

Frequency not reported: Angioneurotic edema, urticaria

Postmarketing reports: Rash, skin disorders[Ref]


Common (1% to 10%): Myalgia, arthrosis, back pain[Ref]


Common (1% to 10%): Constipation, diarrhea, nausea

Uncommon (0.1% to 1%): Dyspepsia, flatulence, vomiting

Frequency not reported: Abdominal pain[Ref]


Common (1% to 10%): Tiredness, drug intolerance, pain, injury, fatigue

Frequency not reported: Asthenia[Ref]


Common (1% to 10%): Nervousness

Uncommon (0.1% to 1%): Nightmares, depression, insomnia, anxiety[Ref]


Uncommon (0.1% to 1%): Impotence[Ref]


Uncommon (0.1% to 1%): Impaired vision[Ref]


Frequency not reported: Decreased platelet count

Postmarketing reports: Thrombocytopenia[Ref]


Frequency not reported: Increased BUN

Postmarketing reports: Acute renal failure[Ref]


Frequency not reported: Hypercholesterolemia, hyperuricemia, increased uric acid, increased triglycerides, decreased HDL cholesterol[Ref]


Postmarketing reports: Abnormal hepatic function (e.g., increased AST, ALT, and bilirubin)[Ref]


Postmarketing reports: Hypersensitivity (e.g., allergic vasculitis, angioedema, urticaria)[Ref]


1. Cerner Multum, Inc. UK Summary of Product Characteristics.

2. Product Information. Bystolic (nebivolol). Forest Pharmaceuticals. 2007.

3. Cerner Multum, Inc. Australian Product Information.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.