Nalocet Side Effects
Generic name: acetaminophen / oxycodone
Medically reviewed by Drugs.com. Last updated on Sep 9, 2023.
Note: This document provides detailed information about Nalocet Side Effects associated with acetaminophen / oxycodone. Some dosage forms listed on this page may not apply specifically to the brand name Nalocet.
Applies to acetaminophen / oxycodone: oral solution, oral tablet.
Important warnings
This medicine can cause some serious health issues
Serious side effects of Nalocet
Along with its needed effects, acetaminophen / oxycodone may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking acetaminophen / oxycodone:
More common
- black, tarry stools
- chills
- dark urine
- dizziness
- fever
- headache
- itching, skin rash
- light-colored stools
- loss of appetite
- nausea
- stomach pain
- unpleasant breath odor
- unusual tiredness or weakness
- vomiting of blood
- yellow eyes or skin
Rare
- cough
- fever with or without chills
- general feeling of tiredness or weakness
- hoarseness
- lower back or side pain
- painful or difficult urination
- sore throat
- sores, ulcers, or white spots on the lips or in the mouth
- unusual bleeding or bruising
Incidence not known
- back, leg, or stomach pains
- bleeding gums
- bloating
- blood in the urine or stools
- blue lips and fingernails
- blurred vision
- burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
- chest pain, discomfort, or tightness
- cloudy urine
- clumsiness
- confusion
- constipation
- coughing that sometimes produces a pink frothy sputum
- darkening of the skin
- decreased awareness or responsiveness
- decreased frequency or amount of urine
- diarrhea
- difficult, fast, noisy breathing
- difficulty in passing urine (dribbling)
- difficulty with swallowing
- dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
- drowsiness
- dry mouth
- extremely shallow or slow breathing
- fainting
- fast or deep breathing
- fast, slow, irregular, pounding, or racing heartbeat
- feeling of warmth
- general body swelling
- hives or welts
- increased sweating
- increased thirst
- indigestion
- large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or genitals
- lightheadedness
- mental depression
- muscle aches, tremors, or weakness
- nervousness
- nosebleeds
- pains in the stomach, side, or abdomen, possibly radiating to the back
- pale skin
- pinpoint red spots on the skin
- pounding in the ears
- puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
- rapid, deep or shallow breathing
- redness of the face, neck, arms, and occasionally, upper chest
- restlessness
- seizures
- severe constipation
- severe sleepiness
- severe vomiting
- skin blisters
- sleepiness
- stomach cramps
- sunken eyes
- sweating
- swelling of the face, fingers, lower legs, or ankles
- thirst
- tiredness
- trouble breathing
- vomiting
- weakness or heaviness of the legs
- weight gain
Get emergency help immediately if any of the following symptoms of overdose occur while taking acetaminophen / oxycodone:
Symptoms of overdose
- bluish lips or skin
- change in consciousness
- cold, clammy skin
- extreme sleepiness
- general feeling of discomfort or illness
- loss of consciousness
- low blood pressure or pulse
- slow breathing
- unconsciousness
Other side effects of Nalocet
Some side effects of acetaminophen / oxycodone may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
- relaxed and calm feeling
Incidence not known
- agitation
- bad, unusual or unpleasant (after) taste
- belching
- change in taste
- cold sweats
- constricted, pinpoint, or small pupils (black part of the eye)
- continuing ringing or buzzing or other unexplained noise in the ears
- cool, pale skin
- depression
- difficulty with moving
- disturbed color perception
- double vision
- excess air or gas in the stomach or bowels
- false or unusual sense of well-being
- flushed, dry skin
- fruit-like breath odor
- full feeling
- general feeling of discomfort or illness
- halos around lights
- hearing loss
- heartburn
- increased hunger
- increased urination
- indigestion
- joint pain
- lack or loss of strength
- muscle cramps, spasms, pain, or stiffness
- night blindness
- nightmares
- overbright appearance of lights
- seeing, hearing, or feeling things that are not there
- seizures
- shakiness
- slurred speech
- swollen joints
- trouble sleeping
- tunnel vision
- unexplained weight loss
- unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness
For healthcare professionals
Applies to acetaminophen / oxycodone: oral capsule, oral solution, oral tablet, oral tablet extended release.
General
The most commonly reported adverse events have included lightheadedness, dizziness, drowsiness, sedation, nausea, and vomiting.[Ref]
Respiratory
- Common (1% to 10%): Cough
- Frequency not reported: Apnea, respiratory arrest, respiratory depression, hiccups
- Postmarketing reports: Bronchospasm, dyspnea, hyperpnea, pulmonary edema, tachypnea, hypoventilation, laryngeal edema[Ref]
Hepatic
Oxycodone-acetaminophen:
- Postmarketing reports: Transient elevations of hepatic enzymes, increased bilirubin, hepatic failure, jaundice, hepatotoxicity, hepatic disorder, hepatitis
Acetaminophen:
- Frequency not reported: Hepatic necrosis[Ref]
At high doses, the most serious acetaminophen related adverse event is a dose-dependent, potentially fatal hepatic necrosis.[Ref]
Hypersensitivity
- Frequency not reported: Skin eruptions, urticaria, erythematous skin reactions
- Postmarketing reports: Anaphylaxis, allergic reaction, angioedema[Ref]
Dermatologic
- Common (1% to 10%): Rash, blister, excoriation, pruritus, erythema
- Frequency not reported: Dermatitis, ecchymosis, hyperhidrosis
- Postmarketing reports: Urticaria, flushing, increased sweating[Ref]
Nervous system
- Very common (10% or more): Dizziness (up to 13%)
- Common (1% to 10%): Headache, somnolence
- Frequency not reported: Lightheadedness, dizziness, drowsiness, sedation, migraine, myoclonus, paresthesia, tremor
- Postmarketing reports: Stupor, cerebral edema, coma, subdural or intracranial hemorrhage, seizures
Opioids:
- Postmarketing reports: Serotonin syndrome[Ref]
Psychiatric
- Frequency not reported: Euphoria, dysphoria, insomnia, altered mood, sleep disorder, withdrawal syndrome
- Postmarketing reports: Agitation, confusion, anxiety, mental impairment, drug dependence, drug abuse, depression, nervousness, hallucination, suicide[Ref]
Gastrointestinal
- Very common (10% or more): Nausea (up to 31%)
- Common (1% to 10%): Vomiting, constipation, dry mouth, dyspepsia, diarrhea
- Frequency not reported: Esophageal spasm, oropharyngeal pain, throat irritation
- Postmarketing reports: Abdominal pain, abdominal distention, flatulence, gastrointestinal disorder, pancreatitis, intestinal obstruction, ileus, thirst[Ref]
Hematologic
Oxycodone-acetaminophen:
- Frequency not reported: Thrombocytopenia, neutropenia, pancytopenia, hemolytic anemia
Acetaminophen:
- Rare (0.01% to 0.1%): Agranulocytosis[Ref]
Renal
- Postmarketing reports: Renal insufficiency and failure[Ref]
Cardiovascular
- Common (1% to 10%): Edema
- Frequency not reported: Hypotension, chest discomfort
- Postmarketing reports: Tachycardia, dysrhythmias, orthostatic hypotension, bradycardia, palpitations, hypertension[Ref]
Metabolic
- Frequency not reported: Decreased appetite
- Postmarketing reports: Hypoglycemia, hyperglycemia, acidosis, alkalosis, hyperkalemia, dehydration
Musculoskeletal
- Postmarketing reports: Rhabdomyolysis, myalgia
Ocular
- Postmarketing reports: Miosis, visual disturbances, red eye
Genitourinary
- Common (1% to 10%): Dysuria
- Frequency not reported: Urinary retention, interstitial nephritis, proteinuria, decreased urine flow
Other
- Postmarketing reports: Malaise, asthenia, fatigue, fever, hypothermia, accidental overdose, non-accidental overdose, hearing loss, tinnitus[Ref]
Endocrine
Opioids:
- Postmarketing reports: Adrenal insufficiency, androgen deficiency
Adrenal insufficiency and androgen deficiency have been reported with opioid use, most often with chronic use.
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Further information
Nalocet side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.