Generic name: OXYCODONE HYDROCHLORIDE 2.5mg, ACETAMINOPHEN 300mg
Dosage form: tablet
Medically reviewed by Drugs.com. Last updated on Nov 17, 2020.
Important Dosage and Administration Instructions
Use the lowest effective dosage for the shortest duration consistent with individual patient treatment goals [see WARNINGS].
Initiate the dosing regimen for each patient individually, taking into account the patient's severity of pain, patient response, prior analgesic treatment experience, and risk factors for addiction, abuse, and misuse [see WARNINGS].
Monitor patients closely for respiratory depression, especially within the first 24 to 72 hours of initiating therapy and following dosage increases with oxycodone and acetaminophen tablets and adjust the dosage accordingly [see WARNINGS].
Initiating Treatment with Oxycodone and Acetaminophen Tablets
The usual adult dosage is 1 or 2 tablets every 6 hours and the maximal daily dose is 12 tablets. The total daily dose of acetaminophen should not exceed 4 grams.
Conversion from Oxycodone and Acetaminophen Tablets to Extended-Release Oxycodone
The relative bioavailability of oxycodone and acetaminophen tablets compared to extended-release oxycodone is unknown, so conversion to extended-release oxycodone must be accompanied by close observation for signs of excessive sedation and respiratory depression.
Titration and Maintenance of Therapy
Individually titrate oxycodone and acetaminophen tablets to a dose that provides adequate analgesia and minimizes adverse reactions. Continually reevaluate patients receiving oxycodone and acetaminophen tablets to assess the maintenance of pain control and the relative incidence of adverse reactions, as well as monitoring for the development of addiction, abuse, or misuse [see WARNINGS]. Frequent communication is important among the prescriber, other members of the healthcare team, the patient, and the caregiver/family during periods of changing analgesic requirements, including initial titration.
If the level of pain increases after dosage stabilization, attempt to identify the source of increased pain before increasing the oxycodone and acetaminophen tablets dosage. If unacceptable opioid-related adverse reactions are observed, consider reducing the dosage. Adjust the dosage to obtain an appropriate balance between management of pain and opioid-related adverse reactions.
Discontinuation of Oxycodone and Acetaminophen Tablets
When a patient who has been taking oxycodone and acetaminophen tablets regularly and may be physically dependent no longer requires therapy with oxycodone and acetaminophen tablets, use a gradual downward titration of the dosage to prevent signs and symptoms of withdrawal. Do not stop oxycodone and acetaminophen tablets abruptly [see WARNINGS, DRUG ABUSE AND DEPENDENCE].
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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