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Nadolol Side Effects

For the Consumer

Applies to nadolol: oral tablet

Warning

Oral route (Tablet)

Following abrupt cessation of therapy with certain beta-blocking agents, exacerbations of angina pectoris and, in some cases, myocardial infarction have occurred. The dosage should be gradually reduced over a period of 1 to 2 weeks and the patient should be carefully monitored when discontinuing chronic therapy, particularly in patients with ischemic heart disease. If angina markedly worsens or acute coronary insufficiency develops, nadolol administration should be reinstated promptly, at least temporarily, and other measures appropriate for the management of unstable angina should be taken. Patients should be warned against interruption or discontinuation of therapy without the physician's advice.

Side effects requiring immediate medical attention

Along with its needed effects, nadolol may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking nadolol:

Less common

  • Blurred vision
  • chest pain or discomfort
  • confusion
  • dilated neck veins
  • dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly
  • extreme fatigue
  • irregular breathing
  • lightheadedness, dizziness, or fainting
  • paleness or cold feeling in fingertips and toes
  • shortness of breath
  • slow or irregular heartbeat
  • sweating
  • swelling of face, fingers, feet, or lower legs
  • tingling or pain in fingers or toes when exposed to cold
  • unusual tiredness or weakness
  • weight gain
  • wheezing

Rare

  • Burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • changes in behavior
  • cough
  • difficulty breathing
  • noisy breathing
  • slurred speech
  • tightness in chest

Side effects not requiring immediate medical attention

Some side effects of nadolol may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Rare

  • Bloated
  • continuing ringing or buzzing or other unexplained noise in ears
  • decreased interest in sexual intercourse
  • diarrhea
  • difficulty having a bowel movement (stool)
  • drowsiness
  • dry mouth, eyes, or skin
  • excess air or gas in stomach or intestines
  • full feeling
  • gas in stomach
  • hair loss, thinning of hair
  • headache
  • hearing loss
  • heartburn
  • inability to have or keep an erection
  • itching skin
  • loss in sexual ability, desire, drive, or performance
  • loss of appetite
  • nausea
  • passing gas
  • rash
  • relaxed and calm
  • sleepiness
  • stomach pain
  • stomach soreness or discomfort
  • stuffy nose
  • vomiting
  • weight loss

For Healthcare Professionals

Applies to nadolol: compounding powder, oral tablet

General

The most common adverse reactions were bradycardia, cardiac failure, rhythm/conduction disturbances, symptoms of peripheral vascular insufficiency, hypotension, dizziness, and fatigue.[Ref]

Cardiovascular

Common (1% to 10%): Heart rate less than 60 beats per minute (bpm), heart rate less than 40 bpm, cardiac failure, rhythm/conduction disturbances, symptoms of peripheral vascular insufficiency usually of the Raynaud type, hypotension

Frequency not reported: First degree and third degree heart block, cold extremities[Ref]

Nervous system

Common (1% to 10%): Dizziness

Uncommon (0.1% to 1%): Paresthesias, sedation, headache, slurred speech, tinnitus

Frequency not reported: Lightheadedness[Ref]

Other

Common (1% to 10%): Fatigue[Ref]

Gastrointestinal

Uncommon (0.1% to 1%): Nausea, diarrhea, abdominal discomfort, constipation, vomiting, indigestion, bloating, flatulence, dry mouth[Ref]

Dermatologic

Uncommon (0.1% to 1%): Rash, pruritus, dry skin, sweating, facial swelling

Frequency not reported: Reversible alopecia[Ref]

Respiratory

Uncommon (0.1% to 1%): Cough, nasal stuffiness, bronchospasm[Ref]

Metabolic

Uncommon (0.1% to 1%): Anorexia, weight gain

Frequency not reported: Hypoglycemia[Ref]

Ocular

Uncommon (0.1% to 1%): Dry eyes, blurred vision[Ref]

Psychiatric

Uncommon (0.1% to 1%): Change in behavior

Frequency not reported: Insomnia[Ref]

Genitourinary

Uncommon (0.1% to 1%): Impotence or decreased libido[Ref]

References

1. "Product Information. Corgard (nadolol)." Bristol-Myers Squibb, Princeton, NJ.

2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.