Monopril HCT Side Effects

Generic name: fosinopril / hydrochlorothiazide

Medically reviewed by Drugs.com. Last updated on Apr 4, 2025.

Note: This document provides detailed information about Monopril HCT Side Effects associated with fosinopril / hydrochlorothiazide. Some dosage forms listed on this page may not apply specifically to the brand name Monopril HCT.

Applies to fosinopril / hydrochlorothiazide: oral tablet.

Precautions

It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly. Blood and urine tests may be needed to check for unwanted effects.

Using this medicine while you are pregnant can harm your unborn baby, especially in your second or third trimester. Use an effective form of birth control to keep from getting pregnant. If you think you have become pregnant while using this medicine, tell your doctor right away.

Check with your doctor right away if you have large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs. These may be symptoms of a condition called angioedema. Black patients also have an increased risk of angioedema. Talk with your doctor if you have concerns about this.

Check with your doctor right away if you have severe stomach pain (with or without nausea or vomiting). This could be a symptom of a condition called intestinal angioedema.

Dizziness, lightheadedness, or fainting may also occur, especially when you get up suddenly from a lying or sitting position or if you have been taking a diuretic (water pill). . If you feel dizzy, lie down so you do not faint. Then sit for a few moments before standing to prevent the dizziness from returning. If you faint, stop using this medicine and call your doctor right away.

Check with your doctor if you have a fever, chills, or sore throat. These could be symptoms of an infection resulting from low white blood cells.

This medicine may affect blood sugar levels. If you notice a change in the results of your blood or urine sugar tests, or if you have any questions, check with your doctor.

Check with your doctor right away if you have symptoms of jaundice (yellow skin or eyes) because these may be signs of a serious liver problem. .

Hyperkalemia (high potassium in the blood) may occur while you are using this medicine. Check with your doctor right away if you have stomach pain, confusion, irregular heartbeat, nausea or vomiting, nervousness, numbness or tingling in the hands, feet, or lips, trouble breathing, or weakness or heaviness of the legs. Ask your doctor before you use medicines, supplements, or salt substitutes that contain potassium.

Check with your doctor right away if you have bloody urine, a decrease in frequency or amount of urine, an increase in blood pressure, increased thirst, loss of appetite, lower back or side pain, nausea, swelling of the face, fingers, or lower legs, trouble breathing, unusual tiredness or weakness, vomiting, or weight gain. These could be symptoms of a serious kidney problem.

Check with your doctor right away if you become sick while taking this medicine, especially with severe or continuing nausea, vomiting, or diarrhea. These conditions may cause you to lose too much water or salt and may lead to low blood pressure. You can also lose water by sweating, so drink plenty of water during exercise or in hot weather.

This medicine may increase your risk of getting skin cancer (eg, non-melanoma skin cancer). Avoid sun exposure. Use a sunscreen when you are outdoors. Avoid sunlamps and tanning beds. Talk to your doctor if you have concerns about this risk.

Alcohol, narcotic pain relievers, or sleeping pills may cause you to feel more lightheaded, dizzy, or faint when used with this medicine. Tell your doctor if you are drinking alcohol or using pain relievers or sleeping pills.

Make sure any doctor or dentist who treats you knows that you are using this medicine. You may need to stop using this medicine several days before having surgery or medical tests.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines for appetite control, asthma, colds, cough, hay fever, or sinus problems, and herbal or vitamin supplements.

Common side effects of Monopril HCT

Some side effects of fosinopril / hydrochlorothiazide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Serious side effects of Monopril HCT

Along with its needed effects, fosinopril/hydrochlorothiazide may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking fosinopril / hydrochlorothiazide:

For healthcare professionals

Applies to fosinopril / hydrochlorothiazide: oral tablet.

General adverse events

The most common adverse reactions were cough, headache, upper respiratory infection, dizziness, weakness, musculoskeletal pain, pharyngitis, and fatigue.^[Ref]

Respiratory

• Common (1% to 10%): Cough, upper respiratory infection, pharyngitis, rhinitis, sinus abnormality, tracheobronchitis
• Uncommon (0.1% to 1%): Congestion, dyspnea, epistaxis, sneezing
• Frequency not reported: Sinus congestion

Fosinopril:

• Common (1% to 10%): Cough, pharyngitis, rhinitis, upper respiratory infection
• Uncommon (0.1% to 1%): Sinus abnormality, tracheobronchitis
• Frequency not reported: Bronchospasm, laryngitis/hoarseness, epistaxis

Hydrochlorothiazide:

• Frequency not reported: Respiratory distress, pneumonitis, pulmonary edema^[Ref]

Gastrointestinal

• Common (1% to 10%): Dyspepsia/heartburn, gastroenteritis, nausea/vomiting, epigastric pain
• Uncommon (0.1% to 1%): Abnormal stool, constipation, diarrhea, abdominal distention, dry mouth, gastritis, oral lesion, intestinal obstruction, abdominal pain, eructation, halitosis
• Frequency not reported: Esophagitis

Fosinopril:

• Common (1% to 10%): Dyspepsia/heartburn, gastroenteritis, nausea/vomiting, epigastric pain
• Frequency not reported: Pancreatitis, dysphagia, abdominal distention, flatulence, dry mouth

Hydrochlorothiazide:

• Frequency not reported: Pancreatitis, sialadenitis, vomiting, diarrhea, cramping, nausea, gastric irritation, constipation^[Ref]

Nervous system

• Common (1% to 10%): Headache, dizziness, vertigo
• Uncommon (0.1% to 1%): Syncope, neuropathy entrapment, memory impairment, numbness, somnolence, paresthesia
• Frequency not reported: Tinnitus

Fosinopril:

• Common (1% to 10%): Dizziness, headache
• Frequency not reported: Cerebrovascular accident, memory disturbance, tremor, taste disturbance

Hydrochlorothiazide:

• Frequency not reported: Vertigo, lightheadedness, headache, paresthesia^[Ref]

Genitourinary

• Common (1% to 10%): Sexual dysfunction, urinary tract infection
• Uncommon (0.1% to 1%): Menstrual disorder, urination abnormality, prostate disorder, vaginal bleeding
• Frequency not reported: Urinary frequency, dysuria

Fosinopril:

• Uncommon (0.1% to 1%): Sexual dysfunction, urinary tract infection

Hydrochlorothiazide:

• Frequency not reported: Glycosuria^[Ref]

Immunologic

• Common (1% to 10%): Viral infection, influenza
• Uncommon (0.1% to 1%): Allergy

Fosinopril:

• Common (1% to 10%): Viral infection, influenza

Hydrochlorothiazide:

• Frequency not reported: Anaphylactic reactions^[Ref]

Other

• Common (1% to 10%): Fatigue, weakness
• Uncommon (0.1% to 1%): Edema, breast disorder, chest pain, chills, fever, cold sensation, malaise, extremity swelling, ear abnormality, ear infection, hearing abnormality
• Frequency not reported: Breast mass, edema lower extremity

Fosinopril:

• Common (1% to 10%): Fatigue, weakness

Hydrochlorothiazide:

• Frequency not reported: Weakness^[Ref]

Musculoskeletal

• Common (1% to 10%): Musculoskeletal pain
• Uncommon (0.1% to 1%): Limitation of movement, muscle cramp, musculoskeletal trauma, musculoskeletal chest pain, tendonitis, extremity weakness
• Frequency not reported: Myalgia

Fosinopril:

• Common (1% to 10%): Musculoskeletal pain
• Frequency not reported: Arthralgia

Hydrochlorothiazide:

• Frequency not reported: Muscle spasm^[Ref]

Cardiovascular

• Common (1% to 10%): Orthostatic hypotension
• Uncommon (0.1% to 1%): Rhythm disturbance, flushing, hypertension, non-angina cardiac chest pain, hot flashes

Fosinopril:

• Frequency not reported: Angina, myocardial infarction, hypertensive crisis, hypotension, claudication

Hydrochlorothiazide:

• Frequency not reported: Orthostatic hypotension, necrotizing angiitis^[Ref]

Dermatologic

• Uncommon (0.1% to 1%): Acne, dermatitis, ecchymosis, extremity erythema, bacterial skin infection, pruritus, rash, skin discomfort, hyperhidrosis, angioedema

Fosinopril:

• Frequency not reported: Urticaria, photosensitivity

Hydrochlorothiazide:

• Frequency not reported: Stevens-Johnson syndrome, purpura, urticaria, rash, photosensitivity^[Ref]

Psychiatric

• Uncommon (0.1% to 1%): Libido change, depression, emotional lability/disturbance, insomnia

Fosinopril:

• Frequency not reported: Confusion, mood change, sleep disturbance

Hydrochlorothiazide:

• Frequency not reported: Restlessness^[Ref]

Metabolic

• Uncommon (0.1% to 1%): Polydipsia, appetite decreased, appetite increased, weight loss

Fosinopril:

• Frequency not reported: Gout, appetite/weight change

Hydrochlorothiazide:

• Frequency not reported: Anorexia, hyperglycemia, hyperuricemia^[Ref]

Hepatic

• Uncommon (0.1% to 1%): Hepatitis

Fosinopril:

• Frequency not reported: Hepatitis, transaminases elevated, lactate dehydrogenase elevated, alkaline phosphatase elevated, serum bilirubin elevated

Hydrochlorothiazide:

• Frequency not reported: Intrahepatic cholestatic jaundice^[Ref]

Hematologic

• Frequency not reported: Neutropenia, hematocrit decreased, hemoglobin decreased, eosinophilia

Fosinopril:

• Frequency not reported: Lymphadenopathy, eosinophilia, hemoglobin decreased, leukopenia

Hydrochlorothiazide:

• Frequency not reported: Aplastic anemia, agranulocytosis, leukopenia, thrombocytopenia, hemolytic anemia^[Ref]

Renal

• Frequency not reported: BUN elevated, creatinine elevated

Fosinopril:

• Frequency not reported: Renal insufficiency, BUN elevated, creatinine elevated^[Ref]

Ocular

Fosinopril:

• Frequency not reported: Vision disturbance, eye irritation

Hydrochlorothiazide:

• Frequency not reported: Transient blurred vision, xanthopsia^[Ref]

See also:

Further information

Monopril HCT side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer