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Monopril HCT Side Effects

Generic name: fosinopril / hydrochlorothiazide

Medically reviewed by Last updated on Apr 28, 2022.

Note: This document contains side effect information about fosinopril / hydrochlorothiazide. Some of the dosage forms listed on this page may not apply to the brand name Monopril HCT.

For the Consumer

Applies to fosinopril/hydrochlorothiazide: oral tablet


Oral route (Tablet)

Drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus. Discontinue therapy as soon as possible when pregnancy is detected.

Side effects requiring immediate medical attention

Along with its needed effects, fosinopril / hydrochlorothiazide may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking fosinopril / hydrochlorothiazide:

Less common

  • Blurred vision
  • chest pain or discomfort
  • chills
  • cold sweats
  • confusion
  • decreased urination
  • dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly
  • dry mouth
  • fainting
  • fast, slow, or irregular heartbeat
  • muscle cramps or pain
  • numbness, tingling, pain, or weakness in the hands or feet
  • rapid breathing
  • seizures
  • sunken eyes
  • sweating
  • thirst
  • trembling
  • unusual tiredness or weakness
  • weakness and heaviness of legs
  • wrinkled skin

Incidence not known

  • Persistent non-healing sore
  • pink growth
  • reddish patch or irritated area
  • shiny bump
  • white, yellow or waxy scar-like area

Side effects not requiring immediate medical attention

Some side effects of fosinopril / hydrochlorothiazide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Cough

Less common

For Healthcare Professionals

Applies to fosinopril / hydrochlorothiazide: oral tablet


The most common adverse reactions were cough, headache, upper respiratory infection, dizziness, weakness, musculoskeletal pain, pharyngitis, and fatigue.[Ref]


Common (1% to 10%): Cough, upper respiratory infection, pharyngitis, rhinitis, sinus abnormality, tracheobronchitis

Uncommon (0.1% to 1%): Congestion, dyspnea, epistaxis, sneezing

Frequency not reported: Sinus congestion


Common (1% to 10%): Cough, pharyngitis, rhinitis, upper respiratory infection

Uncommon (0.1% to 1%): Sinus abnormality, tracheobronchitis

Frequency not reported: Bronchospasm, laryngitis/hoarseness, epistaxis


Frequency not reported: Respiratory distress, pneumonitis, pulmonary edema[Ref]


Common (1% to 10%): Dyspepsia/heartburn, gastroenteritis, nausea/vomiting, epigastric pain

Uncommon (0.1% to 1%): Abnormal stool, constipation, diarrhea, abdominal distention, dry mouth, gastritis, oral lesion, intestinal obstruction, abdominal pain, eructation, halitosis

Frequency not reported: Esophagitis


Common (1% to 10%): Dyspepsia/heartburn, gastroenteritis, nausea/vomiting, epigastric pain

Frequency not reported: Pancreatitis, dysphagia, abdominal distention, flatulence, dry mouth


Frequency not reported: Pancreatitis, sialadenitis, vomiting, diarrhea, cramping, nausea, gastric irritation, constipation[Ref]

Nervous system

Common (1% to 10%): Headache, dizziness, vertigo

Uncommon (0.1% to 1%): Syncope, neuropathy entrapment, memory impairment, numbness, somnolence, paresthesia

Frequency not reported: Tinnitus


Common (1% to 10%): Dizziness, headache

Frequency not reported: Cerebrovascular accident, memory disturbance, tremor, taste disturbance


Frequency not reported: Vertigo, lightheadedness, headache, paresthesia[Ref]


Common (1% to 10%): Sexual dysfunction, urinary tract infection

Uncommon (0.1% to 1%): Menstrual disorder, urination abnormality, prostate disorder, vaginal bleeding

Frequency not reported: Urinary frequency, dysuria


Uncommon (0.1% to 1%): Sexual dysfunction, urinary tract infection


Frequency not reported: Glycosuria[Ref]


Common (1% to 10%): Viral infection, influenza

Uncommon (0.1% to 1%): Allergy


Common (1% to 10%): Viral infection, influenza


Frequency not reported: Anaphylactic reactions[Ref]


Common (1% to 10%): Fatigue, weakness

Uncommon (0.1% to 1%): Edema, breast disorder, chest pain, chills, fever, cold sensation, malaise, extremity swelling, ear abnormality, ear infection, hearing abnormality

Frequency not reported: Breast mass, edema lower extremity


Common (1% to 10%): Fatigue, weakness


Frequency not reported: Weakness[Ref]


Common (1% to 10%): Musculoskeletal pain

Uncommon (0.1% to 1%): Limitation of movement, muscle cramp, musculoskeletal trauma, musculoskeletal chest pain, tendonitis, extremity weakness

Frequency not reported: Myalgia


Common (1% to 10%): Musculoskeletal pain

Frequency not reported: Arthralgia


Frequency not reported: Muscle spasm[Ref]


Common (1% to 10%): Orthostatic hypotension

Uncommon (0.1% to 1%): Rhythm disturbance, flushing, hypertension, non-angina cardiac chest pain, hot flashes


Frequency not reported: Angina, myocardial infarction, hypertensive crisis, hypotension, claudication


Frequency not reported: Orthostatic hypotension, necrotizing angiitis[Ref]


Uncommon (0.1% to 1%): Acne, dermatitis, ecchymosis, extremity erythema, bacterial skin infection, pruritus, rash, skin discomfort, hyperhidrosis, angioedema


Frequency not reported: Urticaria, photosensitivity


Frequency not reported: Stevens-Johnson syndrome, purpura, urticaria, rash, photosensitivity[Ref]


Uncommon (0.1% to 1%): Libido change, depression, emotional lability/disturbance, insomnia


Frequency not reported: Confusion, mood change, sleep disturbance


Frequency not reported: Restlessness[Ref]


Uncommon (0.1% to 1%): Polydipsia, appetite decreased, appetite increased, weight loss


Frequency not reported: Gout, appetite/weight change


Frequency not reported: Anorexia, hyperglycemia, hyperuricemia[Ref]


Uncommon (0.1% to 1%): Hepatitis


Frequency not reported: Hepatitis, transaminases elevated, lactate dehydrogenase elevated, alkaline phosphatase elevated, serum bilirubin elevated


Frequency not reported: Intrahepatic cholestatic jaundice[Ref]


Frequency not reported: Neutropenia, hematocrit decreased, hemoglobin decreased, eosinophilia


Frequency not reported: Lymphadenopathy, eosinophilia, hemoglobin decreased, leukopenia


Frequency not reported: Aplastic anemia, agranulocytosis, leukopenia, thrombocytopenia, hemolytic anemia[Ref]


Frequency not reported: BUN elevated, creatinine elevated


Frequency not reported: Renal insufficiency, BUN elevated, creatinine elevated[Ref]



Frequency not reported: Vision disturbance, eye irritation


Frequency not reported: Transient blurred vision, xanthopsia[Ref]

More about Monopril HCT (fosinopril / hydrochlorothiazide)

Patient resources

Professional resources

Related treatment guides


1. "Product Information. Monopril HCT (fosinopril-hydrochlorothiazide)." Bristol-Myers Squibb, Princeton, NJ.

2. Cerner Multum, Inc. "Australian Product Information." O 0

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.