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Fosinopril / Hydrochlorothiazide Dosage

Medically reviewed by Last updated on Feb 27, 2023.

Applies to the following strengths: 10 mg-12.5 mg; 20 mg-12.5 mg

Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for Hypertension

Fosinopril 10 to 40 mg-Hydrochlorothiazide 12.5 to 37.5 mg orally per day

Comments: The effect of fosinopril 10 mg-hydrochlorothiazide 12.5 mg was similar to the effect seen with monotherapy using either fosinopril 40 mg or hydrochlorothiazide 37.5 mg.

Use: Treatment of hypertension when the desired effect has not been achieved with monotherapy or as substitution for the titrated individual components.

Renal Dose Adjustments

Mild to moderate renal dysfunction (CrCl 30 mL/min/1.73 m2 or greater): No adjustment recommended
Severe renal dysfunction (CrCl less than 30 mL/min/1.73 m2, serum creatinine roughly greater than or equal to 3 mg/dL or 265 mcmol/L): Not recommended

Liver Dose Adjustments

Use with caution



  • FETAL TOXICITY: If pregnancy is detected, discontinue this drug as soon as possible. Drugs that act directly on the renin-angiotensin system (RAS) can cause injury and death to the developing fetus.

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.


Data not available

Other Comments


  • Hematologic: White blood cell counts in patients with collagen vascular disease, especially if the disease is associated with impaired renal function.
  • Metabolic: Serum electrolytes prior to starting treatment and periodically thereafter.
  • Renal: Kidney function during the first few weeks of therapy and periodically thereafter.

Patient advice:
  • Advise patients to immediately report any signs or symptoms of angioedema (breathing difficulty or swelling of face, eyes, lips, or tongue) and to stop taking this drug until consulting a physician.
  • Females of childbearing age should be informed of the consequences of exposure to this drug during pregnancy; ask these patients to report pregnancies as soon as possible.
  • Encourage patients to report any lightheadedness that may occur during treatment initiation and to stop taking this drug until consulting a physician.
  • Caution patients to consult their physician if excessive perspiration, dehydration, vomiting, or diarrhea occurs as it may lead to excessive blood pressure reduction due to reduced fluid volume.
  • Advise patients against using potassium-sparing diuretics, potassium supplements or potassium-containing salt substitutes without consulting their physician.
  • Tell patients to promptly report any sign of infection (e.g., sore throat, fever), which may be a sign of neutropenia.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.