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Fosinopril / hydrochlorothiazide Side Effects

In Summary

More frequently reported side effects include: cough. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to fosinopril / hydrochlorothiazide: oral tablet

In addition to its needed effects, some unwanted effects may be caused by fosinopril / hydrochlorothiazide. In the event that any of these side effects do occur, they may require medical attention.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking fosinopril / hydrochlorothiazide:

Less common:
  • Blurred vision
  • chest pain or discomfort
  • chills
  • cold sweats
  • confusion
  • decreased urination
  • dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly
  • dry mouth
  • fainting
  • fast, slow, or irregular heartbeat
  • muscle cramps or pain
  • numbness, tingling, pain, or weakness in hands or feet
  • rapid breathing
  • seizures
  • sunken eyes
  • sweating
  • thirst
  • trembling
  • unusual tiredness or weakness
  • weakness and heaviness of legs
  • wrinkled skin

Minor Side Effects

Some of the side effects that can occur with fosinopril / hydrochlorothiazide may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common:
  • Cough
Less common:
  • Body aches or pain
  • diarrhea
  • difficult breathing
  • ear congestion
  • fever
  • headache
  • loss of voice
  • muscle or bone pain
  • nasal congestion
  • nausea and vomiting
  • runny nose
  • sneezing
  • sore throat
  • weakness

For Healthcare Professionals

Applies to fosinopril / hydrochlorothiazide: oral tablet


The most common adverse reactions were cough, headache, upper respiratory infection, dizziness, weakness, musculoskeletal pain, pharyngitis, and fatigue.[Ref]


Common (1% to 10%): Cough, upper respiratory infection, pharyngitis, rhinitis, sinus abnormality, tracheobronchitis
Uncommon (0.1% to 1%): Congestion, dyspnea, epistaxis, sneezing
Frequency not reported: Sinus congestion

Common (1% to 10%): Cough, pharyngitis, rhinitis, upper respiratory infection
Uncommon (0.1% to 1%): Sinus abnormality, tracheobronchitis
Frequency not reported: Bronchospasm, laryngitis/hoarseness, epistaxis

Frequency not reported: Respiratory distress, pneumonitis, pulmonary edema[Ref]


Common (1% to 10%): Dyspepsia/heartburn, gastroenteritis, nausea/vomiting, epigastric pain
Uncommon (0.1% to 1%): Abnormal stool, constipation, diarrhea, abdominal distention, dry mouth, gastritis, oral lesion, intestinal obstruction, abdominal pain, eructation, halitosis
Frequency not reported: Esophagitis

Common (1% to 10%): Dyspepsia/heartburn, gastroenteritis, nausea/vomiting, epigastric pain
Frequency not reported: Pancreatitis, dysphagia, abdominal distention, flatulence, dry mouth

Frequency not reported: Pancreatitis, sialadenitis, vomiting, diarrhea, cramping, nausea, gastric irritation, constipation[Ref]

Nervous system

Common (1% to 10%): Headache, dizziness, vertigo
Uncommon (0.1% to 1%): Syncope, neuropathy entrapment, memory impairment, numbness, somnolence, paresthesia
Frequency not reported: Tinnitus

Common (1% to 10%): Dizziness, headache
Frequency not reported: Cerebrovascular accident, memory disturbance, tremor, taste disturbance

Frequency not reported: Vertigo, lightheadedness, headache, paresthesia[Ref]


Common (1% to 10%): Sexual dysfunction, urinary tract infection
Uncommon (0.1% to 1%): Menstrual disorder, urination abnormality, prostate disorder, vaginal bleeding
Frequency not reported: Urinary frequency, dysuria

Uncommon (0.1% to 1%): Sexual dysfunction, urinary tract infection

Frequency not reported: Glycosuria[Ref]


Common (1% to 10%): Viral infection, influenza
Uncommon (0.1% to 1%): Allergy

Common (1% to 10%): Viral infection, influenza

Frequency not reported: Anaphylactic reactions[Ref]


Common (1% to 10%): Fatigue, weakness
Uncommon (0.1% to 1%): Edema, breast disorder, chest pain, chills, fever, cold sensation, malaise, extremity swelling, ear abnormality, ear infection, hearing abnormality
Frequency not reported: Breast mass, edema lower extremity

Common (1% to 10%): Fatigue, weakness

Frequency not reported: Weakness[Ref]


Common (1% to 10%): Musculoskeletal pain
Uncommon (0.1% to 1%): Limitation of movement, muscle cramp, musculoskeletal trauma, musculoskeletal chest pain, tendonitis, extremity weakness
Frequency not reported: Myalgia

Common (1% to 10%): Musculoskeletal pain
Frequency not reported: Arthralgia

Frequency not reported: Muscle spasm[Ref]


Common (1% to 10%): Orthostatic hypotension
Uncommon (0.1% to 1%): Rhythm disturbance, flushing, hypertension, non-angina cardiac chest pain, hot flashes

Frequency not reported: Angina, myocardial infarction, hypertensive crisis, hypotension, claudication

Frequency not reported: Orthostatic hypotension, necrotizing angiitis[Ref]


Uncommon (0.1% to 1%): Acne, dermatitis, ecchymosis, extremity erythema, bacterial skin infection, pruritus, rash, skin discomfort, hyperhidrosis, angioedema

Frequency not reported: Urticaria, photosensitivity

Frequency not reported: Stevens-Johnson syndrome, purpura, urticaria, rash, photosensitivity[Ref]


Uncommon (0.1% to 1%): Libido change, depression, emotional lability/disturbance, insomnia

Frequency not reported: Confusion, mood change, sleep disturbance

Frequency not reported: Restlessness[Ref]


Uncommon (0.1% to 1%): Polydipsia, appetite decreased, appetite increased, weight loss

Frequency not reported: Gout, appetite/weight change

Frequency not reported: Anorexia, hyperglycemia, hyperuricemia[Ref]


Uncommon (0.1% to 1%): Hepatitis

Frequency not reported: Hepatitis, transaminases elevated, lactate dehydrogenase elevated, alkaline phosphatase elevated, serum bilirubin elevated

Frequency not reported: Intrahepatic cholestatic jaundice[Ref]


Frequency not reported: Neutropenia, hematocrit decreased, hemoglobin decreased, eosinophilia

Frequency not reported: Lymphadenopathy, eosinophilia, hemoglobin decreased, leukopenia

Frequency not reported: Aplastic anemia, agranulocytosis, leukopenia, thrombocytopenia, hemolytic anemia[Ref]


Frequency not reported: BUN elevated, creatinine elevated

Frequency not reported: Renal insufficiency, BUN elevated, creatinine elevated[Ref]


Frequency not reported: Vision disturbance, eye irritation

Frequency not reported: Transient blurred vision, xanthopsia[Ref]


1. "Product Information. Monopril HCT (fosinopril-hydrochlorothiazide)." Bristol-Myers Squibb, Princeton, NJ.

2. Cerner Multum, Inc. "Australian Product Information." O 0

Not all side effects for fosinopril / hydrochlorothiazide may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

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