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Mesoridazine Side Effects

Applies to mesoridazine: injectable solution, oral concentrate, oral tablet

Cardiovascular

Drugs with the potential to prolong the QTc interval have been associated with torsades de pointes-type arrhythmias and sudden death.[Ref]

Cardiovascular side effects including hypotension and tachycardia have been reported. Mesoridazine has also been reported to prolong the QTc interval in a dose related manner.[Ref]

Nervous system

Central nervous system side effects including drowsiness, Parkinson's syndrome, dizziness, weakness, tremor, restlessness, ataxia, dystonia, rigidity, slurring, akathisia, and motoric reactions (opisthotonos) have been reported. Autonomic nervous system effects including dry mouth, nausea and vomiting, fainting, stuffy nose, photophobia, constipation, and blurred vision have also been reported.[Ref]

Adverse effects including rigidity and motoric effects tend to occur later in therapy.[Ref]

Genitourinary

Genitourinary side effects including inhibition of ejaculation, impotence, enuresis, incontinence and priapism have been reported.[Ref]

Dermatologic

Dermatologic side effects including itching, rash, hypertrophic papillae of the tongue, and angioneurotic edema have been reported.[Ref]

References

1. "Product Information. Serentil (mesoridazine)" Boehringer-Ingelheim, Ridgefield, CT.

2. Starck LC, Talley BJ, Brannan SK "Mesoridazine use and priapism [letter]." Am J Psychiatry 151 (1994): 946

3. Compton MT, Miller AH "Priapism associated with conventional and atypical antipsychotic medications: A review." J Clin Psychiatry 62 (2001): 362-6

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

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