Loracarbef Side Effects
Medically reviewed by Drugs.com. Last updated on Sep 29, 2022.
Applies to loracarbef: oral capsule, oral powder for reconstitution.
Loracarbef is generally well tolerated.[Ref]
Gastrointestinal side effects have included diarrhea (4.1%), nausea (1.9%), vomiting (1.4%), abdominal pain (1.4%), and anorexia. The incidence of side effects increases with higher doses. Pseudomembranous colitis has been reported in patients treated with beta-lactam antibiotics.[Ref]
Hypersensitivity reactions have included rash (1.2%), urticaria, pruritus, and erythema multiforme. Anaphylaxis, serum-sickness-like reactions, and Stevens-Johnson syndrome have been reported rarely. Beta-lactam antibiotics have been associated with toxic epidermal necrolysis,[Ref]
Hematologic side effects have included transient thrombocytopenia, leukopenia, and eosinophilia. Beta-lactam antibiotics as a class have been associated with agranulocytosis, aplastic anemia, hemolytic anemia, hemorrhage, positive direct Coombs' test, pancytopenia, neutropenia, and prolonged prothrombin time.[Ref]
Renal side effects have included transient elevations in serum creatinine and BUN. Some beta-lactam antibiotics have been associated with toxic nephropathy.[Ref]
A 73-year-old man developed itching and jaundice, pale stools, and right upper quadrant pain two weeks after completion of a four week course of loracarbef for pneumonia. Bilirubin, AST, ALT, alkaline phosphatase levels were elevated. Liver biopsy showed widening of portal areas, pericellular fibrosis, and irregular fibrous bands in the parenchyma. Swollen hepatocytes and cholestasis in the cytoplasma and canaliculi were observed. Lab values returned to normal after 10 weeks.[Ref]
Hepatic side effects have included transient elevations in AST (SGOT), ALT (SGPT), and alkaline phosphatase. Hepatic dysfunction including cholestasis with or without jaundice has been rarely reported. Some beta-lactam antibiotics have been associated with LDH elevations.[Ref]
Cardiovascular side effects have included vasodilatation.[Ref]
Genitourinary side effects have included vaginitis (1.3%) and vaginal moniliasis (1.1%).[Ref]
More about loracarbef
- Check interactions
- Reviews (1)
- Dosage information
- During pregnancy
- Drug class: second generation cephalosporins
Related treatment guides
1. Therasse DG "The safety profile of loracarbef: clinical trials in respiratory, skin, and urinary tract infections." Am J Med 92 (1992): s20-5
2. "Product Information. Lorabid (loracarbef)." Lilly, Eli and Company (2002):
3. Brogden RN, McTavish D "Loracarbef. A review of its antimicrobial activity, pharmacokinetic properties and therapeutic efficacy." Drugs 45 (1993): 716-36
4. Bjornsson E, Olsson R "Acute liver injury due to loracarbef." J Hepatol 26 (1997): 739-40
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Some side effects may not be reported. You may report them to the FDA.