Loracarbef Side Effects
For the Consumer
Applies to loracarbef: oral capsule, oral powder for suspension
Along with its needed effects, loracarbef may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor as soon as possible if any of the following side effects occur while taking loracarbef:
- skin rash
Some side effects of loracarbef may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
For Healthcare Professionals
Applies to loracarbef: oral capsule, oral powder for reconstitution
Loracarbef is generally well tolerated.[Ref]
Gastrointestinal side effects have included diarrhea (4.1%), nausea (1.9%), vomiting (1.4%), abdominal pain (1.4%), and anorexia. The incidence of side effects increases with higher doses. Pseudomembranous colitis has been reported in patients treated with beta-lactam antibiotics.[Ref]
Hypersensitivity reactions have included rash (1.2%), urticaria, pruritus, and erythema multiforme. Anaphylaxis, serum-sickness-like reactions, and Stevens-Johnson syndrome have been reported rarely. Beta-lactam antibiotics have been associated with toxic epidermal necrolysis,[Ref]
Respiratory side effects have included rhinitis (1.6%).[Ref]
Hematologic side effects have included transient thrombocytopenia, leukopenia, and eosinophilia. Beta-lactam antibiotics as a class have been associated with agranulocytosis, aplastic anemia, hemolytic anemia, hemorrhage, positive direct Coombs' test, pancytopenia, neutropenia, and prolonged prothrombin time.[Ref]
Renal side effects have included transient elevations in serum creatinine and BUN. Some beta-lactam antibiotics have been associated with toxic nephropathy.[Ref]
Hepatic side effects have included transient elevations in AST (SGOT), ALT (SGPT), and alkaline phosphatase. Hepatic dysfunction including cholestasis with or without jaundice has been rarely reported. Some beta-lactam antibiotics have been associated with LDH elevations.[Ref]
A 73-year-old man developed itching and jaundice, pale stools, and right upper quadrant pain two weeks after completion of a four week course of loracarbef for pneumonia. Bilirubin, AST, ALT, alkaline phosphatase levels were elevated. Liver biopsy showed widening of portal areas, pericellular fibrosis, and irregular fibrous bands in the parenchyma. Swollen hepatocytes and cholestasis in the cytoplasma and canaliculi were observed. Lab values returned to normal after 10 weeks.[Ref]
Cardiovascular side effects have included vasodilatation.[Ref]
Genitourinary side effects have included vaginitis (1.3%) and vaginal moniliasis (1.1%).[Ref]
1. Therasse DG "The safety profile of loracarbef: clinical trials in respiratory, skin, and urinary tract infections." Am J Med 92 (1992): s20-5
2. Brogden RN, McTavish D "Loracarbef. A review of its antimicrobial activity, pharmacokinetic properties and therapeutic efficacy." Drugs 45 (1993): 716-36
3. "Product Information. Lorabid (loracarbef)." Lilly, Eli and Company, Indianapolis, IN.
4. Bjornsson E, Olsson R "Acute liver injury due to loracarbef." J Hepatol 26 (1997): 739-40
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.
More about loracarbef
- During Pregnancy or Breastfeeding
- Dosage Information
- Drug Interactions
- 1 Review
- Drug class: second generation cephalosporins