Lodoco Side Effects

Generic name: colchicine

Medically reviewed by Drugs.com. Last updated on Apr 6, 2023.

Note: This document contains side effect information about colchicine. Some dosage forms listed on this page may not apply to the brand name Lodoco.

Applies to colchicine: oral capsule, oral solution, oral tablet.

Serious side effects of Lodoco

Along with its needed effects, colchicine (the active ingredient contained in Lodoco) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking colchicine:

More common

Diarrhea
nausea
stomach pain
vomiting

Rare

Black, tarry stools
blood in the urine or stools
burning, "crawling", or tingling feeling in the skin
difficulty with breathing when exercising
fever with or without chills
headache
large, hive-like swellings on the face, eyelids, mouth, lips, or tongue
muscle weakness
numbness in the fingers or toes (usually mild)
pain
peeling of the skin
pinpoint red spots on the skin
redness of the skin
skin rash or hives
sore throat
sores, ulcers, or white spots on the lips or in the mouth
swelling
tenderness
unusual bleeding or bruising
unusual tiredness or weakness

Incidence not known

Bleeding gums
chest pain or tightness
cough
dark urine
headache
high fever
muscle cramps, spasms, or stiffness
muscular pain, tenderness, or wasting
painful or difficult urination
pale skin
sensation of pins and needles
stabbing pain
swollen or painful glands

Get emergency help immediately if any of the following symptoms of overdose occur while taking colchicine:

Symptoms of overdose

Bleeding
burning feeling in the stomach, throat, or skin
chest pain or discomfort
chills
cold, clammy, pale skin
confusion
cough
diarrhea (severe or bloody)
dizziness
eye pain
fever
general feeling of illness
headache
irregular heartbeat
irregular, fast, slow, or shallow breathing
muscle weakness (very severe)
nausea, stomach pain, or vomiting (severe)
seizures
slow heart rate
sore throat
unusual tiredness

Other side effects of Lodoco

Some side effects of colchicine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

Hair loss or thinning of hair
loss of appetite

Incidence not known

Stomach bloating from increased gas
stomach cramping

For Healthcare Professionals

Applies to colchicine: compounding powder, intravenous solution, oral capsule, oral liquid, oral tablet.

General

The most common adverse reactions have included gastrointestinal symptoms and pharyngolaryngeal pain.^[Ref]

Gastrointestinal

Gastrointestinal events including diarrhea, nausea, vomiting, and abdominal pain are the most common adverse reactions reported with use of this drug. These events are often the first signs of toxicity and may indicate the need for dose reduction or therapy discontinuation.^[Ref]

Very common (10% or more): Diarrhea (23%)

Common (1% to 10%): Abdominal cramping, abdominal pain, nausea, vomiting

Frequency not reported: Lactose intolerance, gastrointestinal hemorrhage, paralytic ileus, stomatitis^[Ref]

Hematologic

Rare (less than 0.1%): Agranulocytosis, thrombocytopenia, aplastic anemia

Postmarketing reports: Myelosuppression, disseminated intravascular coagulation^[Ref]

Nervous system

Rare (less than 0.1%): Peripheral neuritis

Frequency not reported: Sensory motor neuropathy^[Ref]

Musculoskeletal

Rare (less than 0.1%): Myopathy, rhabdomyolysis

Frequency not reported: Elevated CPK, myotonia, muscle weakness, muscle pain^[Ref]

Hypersensitivity

Very rare (less than 0.01%): Hypersensitivity including angioedema^[Ref]

Renal

Frequency not reported: Renal damage, bladder spasm, anuria, oliguria^[Ref]

Hepatic

Frequency not reported: elevated AST, elevated ALT, elevated alkaline phosphatase, hepatic damage^[Ref]

Respiratory

Common (1% to 10%): Pharyngolaryngeal pain

Postmarketing reports: Adult respiratory distress syndrome^[Ref]

Ocular

Frequency not reported: Delayed corneal wound healing^[Ref]

There have been reports of corneal ulcers refractory to conventional treatment and delayed corneal wound healing following strabismus surgery in patients receiving colchicine. Discontinuation of colchicine therapy resulted in satisfactory wound healing within several days.^[Ref]