Lodine Side Effects

Generic name: etodolac

Medically reviewed by Drugs.com. Last updated on Nov 19, 2024.

Note: This document provides detailed information about Lodine Side Effects associated with etodolac. Some dosage forms listed on this page may not apply specifically to the brand name Lodine.

Applies to etodolac: oral capsule, oral tablet, oral tablet extended release.

Precautions

It is very important that your doctor check your progress at regular visits. This will allow your doctor to see if the medicine is working properly. Blood and urine tests may be needed to check for unwanted effects.

Using this medicine during the later part of your pregnancy can harm your unborn baby. If you think you have become pregnant while using the medicine, tell your doctor right away.

This medicine may raise your risk of having a heart attack or stroke. This is more likely in people who already have heart disease or in people who use this medicine for a longer time.

This medicine may cause bleeding in your stomach or intestines. These problems can happen without warning signs. This is more likely if you have had a stomach ulcer in the past, if you smoke or drink alcohol regularly, if you are over 60 years old, if you are in poor health, or if you are using certain other medicines (eg, steroids or a blood thinner).

Check with your doctor right away if you have pain or tenderness in the upper stomach, pale stools, dark urine, loss of appetite, nausea, vomiting, or yellow eyes or skin. These could be symptoms of a serious liver problem.

Serious skin reactions, including exfoliative dermatitis, Stevens-Johnson syndrome, toxic epidermal necrolysis, and drug reaction with eosinophilia and systemic symptoms (DRESS) can occur during treatment with this medicine. Check with your doctor right away if you have black, tarry stools, blistering, peeling, or loosening of the skin, chest pain, chills, cough, diarrhea, fever, itching, joint or muscle pain, painful or difficult urination, red irritated eyes, red skin lesions, sore throat, sores, ulcers, or white spots in the mouth or on the lips, swollen glands, unusual bleeding or bruising, or unusual tiredness or weakness.

Possible warning signs of some serious side effects that can occur during treatment with this medicine may include swelling of the face, fingers, feet, or lower legs, severe stomach pain, black, tarry stools, vomiting of blood or material that looks like coffee grounds, unusual weight gain, yellow skin or eyes, decreased urination, unusual bleeding or bruising, or skin rash. Also, signs of serious heart problems could occur including chest pain or tightness, fast or irregular heartbeat, unusual flushing or warmth of skin, weakness, or slurring of speech. Check with your doctor immediately if you notice any of these warning signs.

Check with your doctor right away if you have bloody urine, a decrease in frequency or amount of urine, an increase in blood pressure, increased thirst, loss of appetite, lower back or side pain, nausea, swelling of the face, fingers, or lower legs, trouble breathing, unusual tiredness or weakness, vomiting, or weight gain. These could be symptoms of a serious kidney problem.

This medicine may cause a serious allergic reaction called anaphylaxis, which can be life-threatening and requires immediate medical attention. It may occur more often in patients who are allergic to aspirin or to any of the nonsteroidal anti-inflammatory drugs. Call your doctor right away if you have a rash, itching, trouble breathing or swallowing, or any swelling of your hands, face, or mouth while you are using this medicine.

Before having any kind of surgery or medical tests, tell your doctor that you are using this medicine. It may be necessary for you to stop treatment for a while, or to change to a different NSAID before your procedure.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Serious side effects of Lodine

Along with its needed effects, etodolac (the active ingredient contained in Lodine) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking etodolac:

Symptoms of overdose

• agitation
• change in consciousness
• confusion
• depression
• difficult or trouble breathing
• hives
• hostility
• irregular, fast or slow, or shallow breathing
• irritability
• loss of consciousness
• muscle twitching
• pain or discomfort in chest, upper stomach, or throat
• pale or blue lips, fingernails, or skin
• puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
• rapid weight gain
• seizures
• sleepiness
• stupor
• swelling of face, ankles, or hands
• tightness in chest
• trouble breathing
• unusual drowsiness, dullness, or feeling of sluggishness

Other side effects of Lodine

Some side effects of etodolac may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

For healthcare professionals

Applies to etodolac: oral capsule, oral tablet, oral tablet extended release.

General adverse events

The most frequently reported side effects were gastrointestinal in nature and included dyspepsia, abdominal pain, constipation, diarrhea, dyspepsia, flatulence, gross bleeding/perforation, heartburn, nausea, gastric ulcers, duodenal ulcers, and vomiting.^[Ref]

Gastrointestinal

• Very common (10% or more): Dyspepsia (10%)
• Common (1% to 10%): Abdominal pain, constipation, diarrhea, dyspepsia, flatulence, gross bleeding/perforation, heartburn, nausea, gastric ulcer, duodenal ulcer, vomiting, abdominal distention, epigastric pain, stools abnormal, gastritis, melena
• Very rare (less than 0.01%): Pancreatitis
• Frequency not reported: Dry mouth, ulcerative stomatitis, eructation, peptic ulcer, gastrointestinal (GI) bleeding, perforation, esophagitis, esophageal stricture, cardiospasm, colitis, GI discomfort, burning sensation, gastralgia, upper abdominal discomfort, glossitis, hematemesis, rectal bleeding, heartburn, indigestion, ulcerative colitis exacerbated, Crohn's disease exacerbated
• Postmarketing reports: Intestinal ulceration^[Ref]

Cardiovascular

• Frequency not reported: Hypertension, congestive heart failure, flushing, palpitations, arrhythmia, myocardial infarction, tachycardia, cardiac failure
• Postmarketing reports: Necrotizing vasculitis^[Ref]

Renal

• Common (1% to 10%): Renal function abnormal
• Frequency not reported: Renal calculus, interstitial nephritis, renal impairment, nephrotoxicity, nephrotic syndrome, renal failure
• Postmarketing reports: Renal insufficiency, renal papillary necrosis^[Ref]

Nervous system

• Common (1% to 10%): Dizziness, headache
• Frequency not reported: Syncope, somnolence, cerebrovascular accident, paresthesia, taste perversion, loss of taste, convulsion, coma, tremor, drowsiness, optic neuritis, stroke^[Ref]

Dermatologic

• Common (1% to 10%): Pruritus, rash
• Very rare (less than 0.01%): Stevens-Johnson Syndrome, toxic epidermal necrolysis
• Frequency not reported: Ecchymosis, angioedema, sweating, urticaria, exfoliative dermatitis, vesiculobullous rash, hyperpigmentation, alopecia, maculopapular rash, photosensitivity, skin peeling, purpura, erythema multiforme
• Postmarketing reports: Allergic vasculitis, cutaneous vasculitis, leukocytoclastic vasculitis^[Ref]

Hepatic

• Common (1% to 10%): Liver enzymes increased
• Frequency not reported: Bilirubinuria, hepatitis, jaundice
• Postmarketing reports: Cholestatic hepatitis, hepatitis, cholestatic jaundice, duodenitis, hepatic failure, liver necrosis, fatal fulminant hepatitis^[Ref]

Hematologic

• Common (1% to 10%): Anemia, bleeding time increased
• Frequency not reported: Thrombocytopenia, lymphadenopathy, neutropenia, agranulocytosis, hemolytic anemia, aplastic anemia, pancytopenia, leukopenia^[Ref]

Metabolic

• Frequency not reported: Anorexia
• Postmarketing reports: Hyperglycemia^[Ref]

Psychiatric

• Common (1% to 10%): Depression, nervousness
• Frequency not reported: Insomnia, confusion, anxiety, dreams abnormal, hallucination, disorientation^[Ref]

Genitourinary

• Common (1% to 10%): Dysuria, urinary frequency
• Frequency not reported: Cystitis, hematuria, leukorrhea, uterine bleeding irregular, oliguria, polyuria, proteinuria^[Ref]

Ocular

• Common (1% to 10%): Vision blurred
• Frequency not reported: Photophobia, transient visual disturbance, conjunctivitis^[Ref]

Respiratory

• Frequency not reported: Asthma/aggravated asthma, bronchitis, bronchospasm, dyspnea, pharyngitis, rhinitis, sinusitis, respiratory depression, pneumonia
• Postmarketing reports: Pulmonary infiltration eosinophilic^[Ref]

Musculoskeletal

• Common (1% to 10%): Arthralgia
• Frequency not reported: Muscle pain^[Ref]

Other

• Common (1% to 10%): Edema, tinnitus, fever, chills, asthenia, malaise, fatigue
• Frequency not reported: Serum creatinine increased, infection, weight abnormal, irritability, deafness, meningitis, vertigo, sepsis, death, weakness, aseptic meningitis
• Postmarketing reports: Thirst, BUN increased^[Ref]

Immunologic

• Frequency not reported: Allergic/hypersensitivity reaction, anaphylactic/anaphylactoid reaction^[Ref]

See also:

Further information

Lodine side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer